Higher systemic immune-inflammation index is associated with sarcopenia in individuals aged 18–59 years: a population-based study

Abstract

The association between the systemic immune-inflammation index (SII) and the risk of sarcopenia has not yet been revealed. The purpose of this study was to investigate the relationship between the SII and sarcopenia in individuals aged 18–59 years. All data for this study are from the National Health and Nutrition Examination Survey (NHANES) database, including 7258 participants (age range: 18–59 years). We divided SII values by quartiles (quartiles 1–4: 0.3–3.1, 3.2–4.4, 4.4–6.2, and 6.2–58.5). We constructed a multivariate logistic regression model to assess the association between the SII and the risk of sarcopenia, and an interaction test was run to test the stability of the model and identify high-risk individuals with sarcopenia. Compared to nonsarcopenia participants, sarcopenia patients had a significantly higher SII value (weighted average: 6.65 vs. 5.16) (P = 0.002). Multivariate logistic regression results showed a positive linear relationship between the SII and sarcopenia (OR [odds ratio] = 1.12, 95% CI [confidence interval] 1.03–1.21). Compared to the quartile 1 group, the quartile 4 group was associated with a higher risk of sarcopenia (OR = 3.94, 95% CI 1.42–10.94). Compared with the quartile 1 group, the OR value of the quartile 2 to quartile 4 groups showed an upwards trend (Ptrend < 0.001) as the level of SII increased. Subgroup analysis also indicate that the correlation between higher SII values and the risk of sarcopenia was stable. There was a significant positive linear relationship between SII and sarcopenia, indicating that higher SII values can increase the risk of sarcopenia in individuals aged 18–59 in the United States. The findings of this study will be beneficial in promoting the use of SII alone or in combination with other tools for the risk screening of sarcopenia in communities or large populations.

Comparative evaluation of screening tools for sarcopenia in patients with axial spondyloarthritis

“…4 Significantly different with SARCF + EBM (p < 0.05). 5 Significantly different with Handgrip strength (p < 0.05). 6 Significantly different with Chair stand time (p < 0.05).…”

“…Sarcopenia predominantly affects the elderly; however, younger individuals with chronic diseases are also at risk. The National Health and Nutrition Examination Survey (NHANES) database highlighted that increased systemic immune inflammation escalates the risk of sarcopenia among younger individuals aged 18–59 5 . Therefore, axSpA patients have an elevated risk of developing sarcopenia due to the substantial burden of systemic inflammation.…”

Association of systemic inflammatory indices with anthropometric measures, metabolic factors, and liver function in non-alcoholic fatty liver disease

“…Sarcopenia has been reported to be closely associated with NAFLD. It causes sarcopenia-related obesity, which increases the risk of nonalcoholic steatohepatitis, liver fibrosis, and CVD 44 – 46 . However, due to the lack of data on sarcopenia status in our patients, we were unable to explore the association of SIIs with sarcopenia in the current study, which is suggested to be evaluated in future studies.…”