Higher Triglyceride–Glucose Index Is Associated With Increased Likelihood of Kidney Stones

Qin, Zheng; Zhao, Junjie; Geng, Jiwen; Chang, Kaixi; Liao, Ri-Qiang; Su, Baihai

doi:10.3389/fendo.2021.774567

Cited by 46 publications

(24 citation statements)

References 44 publications

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“…Likewise, insulin resistance may result in a reduction in renal ammonia production, which will lead to a reduction in ammonia buffering and further decrease urine pH ( 28 ). In urine with a pH below 5.5, less soluble uric acid is formed from urate, which can cause uric acid stones ( 29 ). Further, IR increases renal tubule citrate uptake and decreases urinary citrate levels ( 10 ), which is one of the primary causes of calcium stones.…”

Section: Discussionmentioning

confidence: 99%

Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?

et al. 2022

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ObjectiveThe purpose of this study was to examine whether the METS-IR index is associated with kidney stones in American adults.MethodParticipants from the National Health and Nutrition Examination Survey (NHANES) database from 2007-2018 were selected for logistic regression analysis, subgroup analyses, and the calculation of dose-response curves to assess the association between the METS-IR index and the incidence of kidney stones.ResultThis study enrolled 30,612 adults aged >20 years, 2901 of whom self-reported having had kidney stones in the past. And, after controlling for potential confounders, each unit increase in the METS-IR index was linked with a 1.23 percent rise in kidney stone incidence (OR= 1.0123, 95% CI: 1.0092 - 1.0155), with stratified analysis indicating that this was true in all subgroups. Between all groups, an elevated METS-IR index was related to kidney stone formation, and the dose-response curve revealed a positive non-linear connection between METS-IR index and kidney stone risk, with a threshold effect analysis revealing an inflection point value of 50.8314.ConclusionHigher METS-IR index is associated with the occurrence of kidney stones,and while no causative association can be shown, this is cause for concern.

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Section: Discussionmentioning

confidence: 99%

Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?

et al. 2022

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“…New research showed that the TyG index may be an important prognostic indicator of prediabetes patients and can independently predict new cardiovascular and cerebrovascular adverse events (35). Some studies have also proved that with the increase of TyG index, the risk of Diabetes also significantly increased and it was a risk markers of insulin resistance (36)(37)(38). BMI was known to be used to assess the risk of obesity and metabolic diseases and is the most readily available indicator calculated by height and weight (39).…”

Section: Comparisons With Other Studies and What Does The Current Wor...mentioning

confidence: 99%

Triglyceride Glucose-Body Mass Index and Risk of Incident Type 2 Diabetes Mellitus in Japanese People With Normal Glycemic Level: A Population-Based Longitudinal Cohort Study

et al. 2022

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BackgroundIt has been proved that triglyceride glucose-body mass index (TyG-BMI) is a readily available and clinically significant indicator of insulin resistance (IR). Nevertheless, the association between TyG-BMI and incident Type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to study the relationship between TyG-BMI and T2DM and explore the predictive characteristics of TyG-BMI.MethodsOur study was conducted as a longitudinal cohort study. 8,430 men and 7,034 women were enrolled and analyzed. They were both non-diabetic subjects with normal glycemic levels. Follow-up lasted for 13 years, from 1994 to 2016. To make the number of TyG-BMI in each group similar, the subjects were divided into four groups with 3866 subjects in each group.ResultsDuring the 13-year follow-up period, 373 subjects were diagnosed with incident T2DM. Our multivariate Cox regression analysis revealed that TyG-BMI was an independent predictor of incident T2DM. In addition, our research identified four specific groups, young people (18-44 years old), women, the non-hypertensive population and non-drinkers were at significantly higher risk of developing TyG-BMI-related diabetes (P-interaction< 0.05). The best threshold TyG-BMI for predicting incident T2DM was 197.2987 (area under the curve 0.7738).ConclusionsOur longitudinal cohort study demonstrated the positive correlation between baseline TyG-BMI and risk of incident T2DM in Japanese with normal glycemic levels, and this risk was significantly higher in the young people, women, the non-hypertensive population and non-drinkers.

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“…Others had shown diverticular disease risk is positively associated with BMI, body fat percentage, and visceral fat area (Shih et al, 2022) (Freckelton et al, 2018) (Böhm, 2021). Similarly, kidney stones have been associated with the triglyceride-glucose (TyG) index (Qin et al, 2021), and atrial tachycardias have been associated with VLDL levels in metabolic syndrome patients (Lee et al, 2017) (Park & Lee, 2018). Our study is the first to suggest that these associations may be causally related and specific to plasma TG levels, as opposed to or in addition to confounding risk factors, such as obesity and hormone replacement therapy.…”

Section: Discussionmentioning

confidence: 99%

Phenome-wide Mendelian randomization study of plasma triglycerides and 2,600 disease traits

Park

Bafna

Forrest

et al. 2022

Preprint

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BackgroundCausality between plasma triglyceride (TG) levels and atherosclerotic cardiovascular disease (ASCVD) risk remains controversial despite more than four decades of study and two recent landmark trials, STRENGTH and REDUCE-IT. Further unclear is the association between TG levels and non-atherosclerotic diseases across organ systems.MethodsHere, we conducted a phenome-wide, two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW) regression to systematically infer the causal effects of plasma TG levels on 2,600 disease traits in the European ancestry population of UK Biobank. For replication, we externally tested 221 nominally significant associations (p < 0.05) in an independent cohort from FinnGen. To account for potential horizontal pleiotropy and the influence of invalid instrumental variables, we performed sensitivity analyses using MR-Egger regression, weighted median estimator, and MR-PRESSO. Finally, we used multivariable MR controlling for correlated lipid fractions to distinguish the independent effect of plasma TG levels.ResultsOur results identified 7 disease traits reaching Bonferroni-corrected significance in both the discovery (p < 1.92 × 10-5) and replication analyses (p < 2.26 × 10-4), supporting a causal relationship between plasma TG levels and ASCVDs, including coronary artery disease (OR 1.33, 95% CI 1.24-1.43, p = 2.47 × 10-13). We also identified 12 disease traits that were Bonferroni-significant in the discovery or replication analysis and at least nominally significant in the other analysis (p < 0.05), identifying plasma TG levels as a novel risk factor for 9 non-ASCVD diseases, including uterine leiomyoma (OR 1.19, 95% CI 1.10-1.29, p = 1.17 × 10-5).ConclusionsTaking a phenome-wide, two-sample MR approach, we identified causal associations between plasma TG levels and 19 disease traits across organ systems. Our findings suggest unrealized drug repurposing opportunities or adverse effects related to approved and emerging TG-lowering agents as well as mechanistic insights for future study.

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Higher Triglyceride–Glucose Index Is Associated With Increased Likelihood of Kidney Stones

Cited by 46 publications

References 44 publications

Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?

Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?

Triglyceride Glucose-Body Mass Index and Risk of Incident Type 2 Diabetes Mellitus in Japanese People With Normal Glycemic Level: A Population-Based Longitudinal Cohort Study

Phenome-wide Mendelian randomization study of plasma triglycerides and 2,600 disease traits

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