Higher versus lower protein intake in formula-fed term infants

Garay, Alejandro G Gonzalez; Vera, Isabel; Serralde‐Zúñiga, Aurora E.; Hidalgo, Liliana Velasco; Ocaña, Mathy Victoria Alonso

doi:10.1002/14651858.cd013758

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…Another key concern in this area is the lack of a well-thought-out framework that can help improve the design for studies in this area, which accounts for the need to first and foremost protect breastfeeding among malnourished infants. A current Cochrane review is examining whether lower protein content formulas can address malnutrition without the adverse longer-term outcomes of obesity and metabolic disorders [ 57 ]. High income settings face additional considerations on the use of fortifiers and modular nutrients for preterm infants, including cost and cross-contamination of using pumps to express milk to nutrient enrich a supply [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Critical research gaps in treating growth faltering in infants under 6 months: A systematic review and meta-analysis

Tomori,

O’Connor,

Ververs

et al. 2024

PLOS Glob Public Health

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In 2020, 149.2 million children worldwide under 5 years suffered from stunting, and 45.4 million experienced wasting. Many infants are born already stunted, while others are at high risk for growth faltering early after birth. Growth faltering is linked to transgenerational impacts of poverty and marginalization. Few interventions address growth faltering in infants under 6 months, despite a likely increasing prevalence due to the negative global economic impacts of the COVID-19 pandemic. Breastfeeding is a critical intervention to alleviate malnutrition and improve child health outcomes, but rarely receives adequate attention in growth faltering interventions. A systematic review and meta-analysis were undertaken to identify and evaluate interventions addressing growth faltering among infants under 6 months that employed supplemental milks. The review was carried out following guidelines from the USA National Academy of Medicine. A total of 10,405 references were identified, and after deduplication 7390 studies were screened for eligibility. Of these, 227 were assessed for full text eligibility and relevance. Two randomized controlled trials were ultimately included, which differed in inclusion criteria and methodology and had few shared outcomes. Both studies had small sample sizes, high attrition and high risk of bias. A Bangladeshi study (n = 153) found significantly higher rates of weight gain for F-100 and diluted F-100 (DF-100) compared with infant formula (IF), while a DRC trial (n = 146) did not find statistically significant differences in rate of weight gain for DF-100 compared with IF offered in the context of broader lactation and relactation support. The meta-analysis of rate of weight gain showed no statistical difference and some evidence of moderate heterogeneity. Few interventions address growth faltering among infants under 6 months. These studies have limited generalizability and have not comprehensively supported lactation. Greater investment is necessary to accelerate research that addresses growth faltering following a new research framework that calls for comprehensive lactation support.

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Section: Discussionmentioning

confidence: 99%