During the last 50 years or more, increasing population, industrialization, and agricultural development have profoundly impacted on natural ecosystems and water quality (Khan and Hanjra 2009;Park et al. 2010).Water resources are coming under intense pressure in Asia. The Asia Pacific region has the highest annual water withdrawal and return flows among the world's regions due to its geographic size, population, and extensive and intensive irrigation practices. More than half of global irrigation is taking place in Asia and results in a high level of agrochemical consumption, which is nonpoint source pollution. Another form of nonpoint source pollution comes from the topography of the region, resulting in high sediment loads (Evans et al. 2012).The domestic pollution problems are a factor not only of the wastewater generated but also of inadequate treatment and management measures. The volume of wastewater generated annually across Asia is nearly 144 km 3 , of which 37 % is generated in China, 27 % in South Asia, 20 % in Japan, 6 % in Southeast Asia, and 3 % in Central Asia (AQUASTAT 2011; Evans et al. 2012). Only an estimated 33-35 % of all wastewater in Asia is treated, with the lowest treatment rates in South Asia (7 %) and Southeast Asia (14 %) (Table 2.1).Increasing water pollution from accelerating domestic, industrial, and agricultural activities is a major issue for nearly all Asian developing countries. Table 2.2 gives an overview of the level of BOD pollutions among the developing countries in Asia. China, as the largest economy among the regions observed, reported the most pollution, at 8.82 million kg/day in 2006, eclipsing BOD emissions from the other regions. This is compared to a combined total BOD emission of 1.96 million kg/day from Indonesia, Thailand, and Vietnam, the major polluting countries in the Southeast Asian region. These levels were not surprising when viewed in context of the countries' GDP, as in 2006, China's GDP was about 4.6 times of that of the three countries combined.