Highland barley β-glucan alleviated western diet-induced non-alcoholic fatty liver disease via increasing energy expenditure and regulating bile acid metabolism in mice

Abstract

Non-alcoholic fatty liver disease (NAFLD) has become a public health burden. Targeting the bile acids (BAs) metabolism and energy expenditure are potential therapies for NAFLD. Because one of the main...

Highland barley β-glucan supplementation attenuated hepatic lipid accumulation in Western diet-induced non-alcoholic fatty liver disease mice by modulating gut microbiota

“…Numerous studies have shown that gut microbiota and its metabolites play a vital role in the occurrence and development of NAFLD, and their underlying mechanisms include the alleviation of intestinal barrier damage and inhibition of inflammatory response. 32,38 HBG could regulate the structure and composition of gut microbiota. Briefly, the HBG intervention enhanced the richness of gut microbiota and altered its structure in the WD-induced NAFLD mice.…”

“…We found that HBG improved WD-induced glucose homeostasis in NAFLD mice. 32 Therefore, future studies should focus on the effect of HBG on insulin resistance in mice with NAFLD.…”

“…Western blot analysis was performed using the method described in our previous study. 32 The primary antibodies used for western blot are listed in ESI Table S2. †…”

Effects of Oat β-Glucan and Inulin on Alleviation of Nonalcoholic Steatohepatitis Aggravated by Circadian Disruption in C57BL/6J Mice

“…47 This phenomenon might be attributed to the significant increase in another FXR agonist taurolithocholic acid. 47 It has been revealed that oat β-glucan and inulin supplementation could alter the levels of SCFAs, α-diversity or β-diversity. 21,24,26 However, these changes were not demonstrated in our study.…”

“…46 Although the reason for increased hepatic FXR observed in the SOBG group remains unclear, it has been reported that another cereal β-glucan originating from highland barley could also increase the hepatic FXR gene expression. 47 This phenomenon might be attributed to the significant increase in another FXR agonist taurolithocholic acid. 47 It has been revealed that oat β-glucan and inulin supplementation could alter the levels of SCFAs, α-diversity or β-diversity.…”