Highlight: The Epigenetics of Life at 12,000 ft

McGrath, Casey

doi:10.1093/gbe/evaa266

Cited by 2 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By studying members of the Peruvian Quechua, who live at high altitudes in the Andes, the authors identified specific positions and regions of DNA in which methylation was associated with either lifelong or early altitude exposure, some of which were associated with genes previously linked to high-altitude adaptation. As discussed in the Highlight feature on this article ( McGrath 2021b ), the study supports the idea that early developmental exposures can have persistent impacts on DNA methylation patterns in humans. In their study, John A. Capra and coauthors used a machine learning method to impute gene regulation patterns in DNA samples from ancient Eurasians ( Colbran et al 2021 ).…”

supporting

confidence: 76%

Highlight—Epigenetics Virtual Issue: New Findings Amid Old Controversies

McGrath

2022

Genome Biology and Evolution

Self Cite

View full text Add to dashboard Cite

supporting

confidence: 76%

Highlight—Epigenetics Virtual Issue: New Findings Amid Old Controversies

McGrath

2022

Genome Biology and Evolution

Self Cite

View full text Add to dashboard Cite

“… 8 Usually, adaptations are considered genetic alterations that cause a particular physiological trait to develop, a phenomenon known as adaptive plasticity. 9 However, not everyone responds in this way. Some individuals reportedly develop adaptive responses, but others, particularly those with chronic diseases like diabetes, experience complications due to living in such locations.…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Identification of lncRNA and mRNA for Diagnosing Type 2 Diabetes in Saudi Arabia

Albogami

2023

PGPM

View full text Add to dashboard Cite

According to the World Health Organization, Saudi Arabia ranks seventh worldwide in the number of patients with diabetes mellitus. To our knowledge, no research has addressed the potential of noncoding RNA as a diagnostic and/or management biomarker for patients with type 2 diabetes mellitus (T2DM) living in high-altitude areas. This study aimed to identify molecular biomarkers influencing patients with T2DM living in high-altitude areas by analyzing lncRNA and mRNA. Patients and Methods: RNA sequencing and bioinformatics analyses were used to identify significantly expressed lncRNAs and mRNAs in T2DM and healthy control groups. Coding potential was analyzed using coding-noncoding indices, the coding potential calculator, and PFAM, and the lncRNA function was predicted using Pearson's correlation. Differentially expressed transcripts between the groups were identified, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed to identify the biological functions of both lncRNAs and mRNAs. Results: We assembled 1766 lncRNAs in the T2DM group, of which 582 were novel. This study identified three lncRNA target genes (KLF2, CREBBP, and REL) and seven mRNAs (PIK3CD, PIK3R5, IL6R, TYK2, ZAP70, LAMTOR4, and SSH2) significantly enriched in important pathways, playing a role in the progression of T2DM. Conclusion:To the best of our knowledge, this comprehensive study is the first to explore the applicability of certain lncRNAs as diagnostic or management biomarkers for T2DM in females in Taif City, Saudi Arabia through the genome-wide identification of lncRNA and mRNA profiling using RNA seq and bioinformatics analysis. Our findings could help in the early diagnosis of T2DM and in designing effective therapeutic targets.

show abstract

Highlight: The Epigenetics of Life at 12,000 ft

Cited by 2 publications

References 1 publication

Highlight—Epigenetics Virtual Issue: New Findings Amid Old Controversies

Highlight—Epigenetics Virtual Issue: New Findings Amid Old Controversies

Genome-Wide Identification of lncRNA and mRNA for Diagnosing Type 2 Diabetes in Saudi Arabia

Contact Info

Product

Resources

About