Highlighting Immune System and Stress in Major Depressive Disorder, Parkinson’s, and Alzheimer’s Diseases, with a Connection with Serotonin

Abstract

There is recognition that both stress and immune responses are important factors in a variety of neurological disorders. Moreover, there is an important role of several neurotransmitters that connect these factors to several neurological diseases, with a special focus in this paper on serotonin. Accordingly, it is known that imbalances in stressors can promote a variety of neuropsychiatric or neurodegenerative pathologies. Here, we discuss some facts that link major depressive disorder, Alzheimer’s, and Parkinson’s to the stress and immune responses, as well as the connection between these responses and serotonergic signaling. These are important topics of investigation which may lead to new or better treatments, improving the life quality of patients that suffer from these conditions.

Systematic Analysis of Neurotransmitter Receptors in Human Breast Cancer Reveals a Strong Association With Outcome and Uncovers HTR6 as a Survival-Associated Gene Potentially Regulating the Immune Microenvironment

“…In fact, a large number of studies have reported the regulatory relationship between serotonin (as the ligand of HTR6) and immune system. For example, taking the selective serotonin reuptake inhibitors (SSRIs) can cause a decrease in pro-inflammatory cytokines and T helper cell 17 cells (Th17), exhibiting an anti-inflammatory effect ( 50 ). On the other hand, in Figures 3 and 4 , we found that HTR6 expression was associated with changes in phosphorylation of MAPK pathway, JUN pathway, and megakaryocyte differentiation pathway.…”

The Spontaneous Remission of Recurrent Lymph Node Metastatic Prostate Cancer With Lowering Serum Prostate-Specific Antigen Level

“…The mechanisms of spontaneous remission are associated with composite factors including the host immune system and tumor microenvironment [ 13 ]. The host immune system is modulated by the response to microbial infection, surgical intervention, physical trauma, and psychological factors [ 14 , 15 ]. Shibata et al suggested an antineuronal antibody, anti-Hu, in cases of spontaneous remission of small cell lung cancer [ 16 ].…”

Halalopathy: Revival of Miraculous Cure and Creation of Favourable Circumstances for Cancer Therapy

“…Therefore, people with such a condition need to see a physician who can help them regain control of the potential energy and keep the immune system in the fight mode. Otherwise, the immune system will ignore many defects that need to be repaired, and critical diseases such as cancer or other related diseases such as cardiovascular disease, diabetes, or Alzheimer's disease may develop if no action is taken [13][14][15][16]. Hence, if the physician is avoided, it is possible to regain the potential by avoiding/resisting the state of fear and/or grief and replacing it with the state of positivity, the state that is full of potential, optimism, joy, smiles, and hope; and if that still doesn't work, one can seek support, from friends who have a positive personality, who believe that with adversity comes lightness and relief.…”