Highlights and recent developments in allergic diseases in EAACI journals (2019)

Abstract

The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members. There was substantial progress in 2019 in the identification of basic mechanisms of allergic and respiratory disease and the translation of these mechanisms into clinics. Better understanding of molecular and cellular mechanisms, efforts for the development of biomarkers for disease prediction, novel prevention and intervention studies, elucidation of mechanisms of multimorbidities, entrance of new drugs in the clinics as well as recently completed phase three clinical studies and publication of a large number of allergen immunotherapy studies and meta-analyses have been the highlights of the last year.

Detecting common allergens in dogs with atopic dermatitis in South Korean Provinces using a serological immunoglobulin E-specific allergen test

“…The condition was assumed to be caused by interactions between the animal's immune system, genetic preparedness (susceptibility), and dietary or environmental allergen exposure [4,5]. CAD can be caused by a variety of allergens, including mites such as Dermatophagoides pteronyssinus, molds such as Aspergillus fumigatus, and a number of trees and grass, meat, and dairy products [6,7]. Approximately 20% of worldwide domestic dogs are affected by CAD [8].…”

Enhanced expression of endogenous retroviruses and of TRIM28 and SETDB1 in children with food allergy

“…33,34 The understanding of underlying pathophysiology and the identification of molecules involved in the development of FA may contribute to its better prevention and to innovative treatment modalities. 35 Despite the potential impact of HERVs and of TRIM28 and SETDB1 in triggering and/or maintaining allergic reactions, to the best of our knowledge no studies explored their expressions in allergic patients. The aims of the current study were to assess the transcription levels of pol genes of HERV-H, -K, and -W, the three retroviral families most widely studied, 9,21 of env genes of SYN1 and SYN2 as well as of TRIM28 and SETDB1 in whole blood from children affected by IgE-mediated FA or FPIES and in control healthy children.…”

“…The understanding of underlying pathophysiology and the identification of molecules involved in the development of FA may contribute to its better prevention and to innovative treatment modalities 35 . Despite the potential impact of HERVs and of TRIM28 and SETDB1 in triggering and/or maintaining allergic reactions, to the best of our knowledge no studies explored their expressions in allergic patients.…”

Advances and highlights in biomarkers of allergic diseases

“…Several factors including pollution, climate change, reduction in biodiversity, urbanization, change in lifestyle and dietary habits have been attributed to the important rise in allergic cases. [1][2][3][4] Precision medicine, a customized treatment approach, and lifestyle changes can reduce the socioeconomic burden imposed by allergic diseases. These are particularly suited for precision medicine as the representing umbrella characteristics, such as type 2 immunity, comprise different diseases linking an underlying pathomechanism to an endotype or phenotype.…”

“…Several factors including pollution, climate change, reduction in biodiversity, urbanization, change in lifestyle and dietary habits have been attributed to the important rise in allergic cases. 1 , 2 , 3 , 4 …”