Highlights of Recent Findings on Quality-of-Life Management for Patients With Cancer and Their Survivors

Shapiro, Charles L.

doi:10.1001/jamaoncol.2016.3620

Cited by 26 publications

(24 citation statements)

References 12 publications

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“…However, chemotherapy, and radiotherapy-induced adverse effects including oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity, hinder the clinical uses. Subsequently, these harmful effects often reduce the quality of life in cancer patients, and may lead to therapy discontinuation (Shapiro, 2016 ; Turcotte et al, 2017 ). Therefore, it is important to develop effective management strategies against chemotherapy and radiotherapy-induced side effects.…”

Section: Introductionmentioning

confidence: 99%

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

et al. 2018

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Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively reduces the quality of life in cancer patients. Natural products including crude extracts, bioactive components-enriched fractions and pure compounds prepared from herbs as well as herbal formulas have been proved to prevent and treat cancer. Of significant interest, some natural products can reduce chemotherapy and radiotherapy-induced oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity. This review focuses in detail on the effectiveness of these natural products, and describes the possible mechanisms of the actions in reducing chemotherapy and radiotherapy-induced side effects. Recent advances in the efficacy of natural dietary supplements to counteract these side effects are highlighted. In addition, we draw particular attention to gut microbiotan in the context of prebiotic potential of natural products for the protection against cancer therapy-induced toxicities. We conclude that some natural products are potential therapeutic perspective for the prevention and treatment of chemotherapy and radiotherapy-induced side effects. Further studies are required to validate the efficacy of natural products in cancer patients, and elucidate potential underlying mechanisms.

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Section: Introductionmentioning

confidence: 99%

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

et al. 2018

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“…The authors combined distribution-based analyses with cross-sectional anchor-based analyses to obtain minimally important differences (MIDs) in FACT-G subscale scores (2–3 points), FACT-G total scores (6–7 points), Hepatobiliary Cancer Subscale scores (MID 5–6 points), and FACT-Hep scores (MID 8–9 points). However, data for clinically significant improvements in HCC surgery outcomes, particularly patient-reported outcomes, are very limited [4,5,6]. For patients who undergo surgical resection of HCC, the current study obtained MCID values of 3.6 for SF-36 PCS; 4.2 for SF-36 MCS; 5.4 for FACT-G total score; and 6.7 for FACT-Hep total score.…”

Section: Discussionmentioning

confidence: 75%

“…It is important not to mix up the concept of quality of life with a recently growing area of HRQoL. Quality of life is an essential concept in the field of international development since it allows analysis of development on a measure broader than the standard of living [6,7]. Within development theory, however, there are varying ideas concerning what constitutes desirable change for a particular society, and the different ways that institutions define the quality of life, therefore, shapes how these organizations work for its improvement as a whole.…”

Section: Introductionmentioning

confidence: 99%

“…A clinically important difference is a change that a patient or clinician would consider meaningful or worthwhile, such that an intervention or treatment would be considered worthy of repeating or such that patients would consider the change as an improvement in HRQoL. As such, measures of clinical significance such as the minimal clinically important difference (MCID) are increasingly used as a standard clinical outcome measure [6,7]. The MCID is defined as the smallest outcome change that the patient perceives as clinically important [9].…”

Section: Introductionmentioning

confidence: 99%

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Preoperative Health-Related Quality of Life Predicts Minimal Clinically Important Difference and Survival after Surgical Resection of Hepatocellular Carcinoma

Chiu

Lee

Wang

et al. 2019

JCM

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Despite the growing use of minimal clinically important difference (MCID) as a cancer outcome measure, no study has reported clinically significant outcomes in cancer patients. We defined MCID and evaluated the use of preoperative HRQoL for predicting MCID and survival after surgical resection of hepatocellular carcinoma (HCC). In total, 369 patients completed the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) and the SF-36 at baseline and at two years post-operative at three tertiary academic hospitals. The corresponding MCID values were 3.6 (SF-36 physical component summary), 4.2 (SF-36 mental component summary), 5.4 (FACT-General total score), and 6.7 (FACT-Hep total score). The predictors of achieving postoperative MCID were significantly higher in patients who had low preoperative HRQoL score, advanced age, high education level, and high BMI (p < 0.05). However, patients with a high preoperative HRQoL score, high education level, high BMI, and low Charlson comorbidity index score were significantly associated with survival (p < 0.05). Preoperative HRQoL scores were predictive of MCID and overall survival after surgical resection of HCC. The findings of this study may be useful for managing the preoperative expectations of candidates for HCC resection and for developing shared decision-making procedures for patients undergoing surgical resection of HCC.

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“…To date, chemotherapy and radiotherapy are common methods of cancer treatment [1], but they are accompanied by serious side effects [2,3]. In fact, folic acid (FA) receptor, having overexpression on the surface of various cancer cells including the brain, breast, lungs and so on, has been widely employed as tumor targeted ligand in selective drug delivery [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

SERS imaging elucidates the folate receptor-mediated photothermal/photodynamic synergistic anticancer nanodrugs-induced cell apoptosis

Tang¹,

Xing²,

Tao³

et al. 2020

Preprint

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Background: Chemotherapy and radiotherapy are common methods of cancer treatment, but they are accompanied by serious side effects. Actually, many cancer cells have overexpression of folic acid (FA) receptor and by FA receptor-mediated endocytosis, anticancer drugs can be easily internalized into cancer cell, this will greatly improve the curative effect and decrease side effects. Along with the development of nanotechnology, phototherapy, owning advantages in tissue selectivity, process controlling, low toxicity and reproducible treatment, has become very promising, especially for photothermal therapy (PTT) and photodynamic therapy (PDT). Since both PTT and PDT involve the utilization of light energy, so they synergistic treatment should be a good solution by ingenious design. In this paper, based on surface enhanced Raman spectroscopy (SERS) imaging, we hope to construct a FA receptor-mediated PTT/PDT synergistic anticancer nanodrug (nanoprobe), and achieve the intracellular distribution information of the nanodrugs during cell apoptosis, and then elucidate PTT/PDT-induced cell apoptosis and synergistic efficiency.Results: FA receptor-mediated PTT/PDT synergistic anticancer nanodrugs with tracing function are prepared by the chemical synthesis and modification of gold nanorods (GNR), involving protoporphyrin IX (PpIX), 4-mecaptobenzoic acid (MBA), and FA. Based on SERS imaging, it is found that the FA receptor-mediated endocytosis can greatly facilitate the nanodrugs internalization, in which both the number and intracellular dispersion of the PpIX-GNR-MBA-FA nanodrugs are improved relative to the GNR-MBA or PpIX-GNR-MBA compositions, and then enhance the PTT/PDT-induced cell apoptosis.Conclusion: SERS imaging is very suitable for the phototherapy tracing due to its high sensitivity and stability. The FA receptor-mediated way can significantly facilitate nanodrugs internalization, PTT/PDT-induced cell apoptosis and synergistic efficiency. Importantly, this FA receptor-mediated SERS imaging based PTT/PDT synergistic treatment will provide a novel strategy for the design and application of anticancer phototherapy nanodrugs.

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Highlights of Recent Findings on Quality-of-Life Management for Patients With Cancer and Their Survivors

Cited by 26 publications

References 12 publications

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

Preoperative Health-Related Quality of Life Predicts Minimal Clinically Important Difference and Survival after Surgical Resection of Hepatocellular Carcinoma

SERS imaging elucidates the folate receptor-mediated photothermal/photodynamic synergistic anticancer nanodrugs-induced cell apoptosis

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