Highlights of the 19th International Conference on Behçet's Syndrome

Esatoğlu, Sinem Nihal; Kutlubay, Zekayі; Hatemi, Gülen

doi:10.55563/clinexprheumatol/l7qkhb

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…This finding may be associated with the low use of biological drugs in our patients, as shown in a study from Turkey, where new major involvement, relapse, or both occurred in 36% of the patients receiving immunosuppressive therapy, with a higher frequency of relapses in patients receiving conventional therapies than in those receiving biologic therapies. 24 The treatment in our cohort was similar to that reported in cohorts from Egypt, Japan, and Spain. [19][20][21] In the present study, men presented with a higher frequency of comorbidities, such as obesity and arterial hypertension.…”

Section: Discussionsupporting

confidence: 86%

“…4 For example, a study from Russia reported a predominance of neurological and gastrointestinal phenotypes, whereas the predominant phenotype in a large cohort of Chinese patients was the skin and mucosa type. 23,24 In addition, the coexistence of different phenotypes and changes during the course of the disease has been reported. 25 Further studies are needed to clarify whether these are real differences or a result of methodological differences, disease criteria, definitions, and time of ascertainment of clinical manifestations.…”

Section: Discussionmentioning

confidence: 99%

“…Different phenotypes with clustering of certain organ manifestations have been proposed, with variations according to ethnicity and geographic region, without sufficient insight as to whether these clusters represent different disease mechanisms 4 . For example, a study from Russia reported a predominance of neurological and gastrointestinal phenotypes, whereas the predominant phenotype in a large cohort of Chinese patients was the skin and mucosa type 23,24 . In addition, the coexistence of different phenotypes and changes during the course of the disease has been reported 25 .…”

Section: Discussionmentioning

confidence: 99%

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Clinical Characteristics and Outcomes of Mexican Patients With Behçet’s Syndrome

Hinojosa-Azaola,

Ramírez-Mulhern,

Figueroa-Pariente

et al. 2023

J Clin Rheumatol

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ObjectiveThe aim of this study was to describe the clinical characteristics and outcomes of Mexican patients with Behçet syndrome (BS) from a single center.MethodsThis medical records review study included patients with established BS diagnosis, followed up in a tertiary care center in Mexico City from 2000 to 2020. Demographics, clinical characteristics, laboratory and imaging studies, disease activity, damage, treatment, and outcomes were assessed and compared according to sex and with other international cohorts. Descriptive statistics were used, and differences between groups were evaluated using the χ2 or Mann-Whitney U tests.ResultsThirty-eight patients were included, 23 (60%) women and 15 (40%) men; the median age at BS diagnosis was 33 years (range, 24–39 years). The most frequent manifestations at diagnosis were recurrent oral and genital ulcers in 34 (89%) and 29 (76%), respectively, musculoskeletal in 21 (55%), and cutaneous in 15 (39%). The most frequent phenotype was the joint involvement. Treatment comprised prednisone in all, colchicine (24 [63%]), pentoxifylline (12 [32%]), and thalidomide (10 [26%]). During a median follow-up time of 12.5 years (range, 7–23 years), relapses were frequent (97%), severe infections were present in 5 patients (13%), and 2 patients (5%) died due to sepsis and pneumonia. Men showed a higher frequency of arterial hypertension (47% vs. 13%, p = 0.03) and thrombosis (20% vs. 0, p = 0.05), and a lower frequency of genital ulcers (40% vs. 78%, p = 0.03) than women.ConclusionsThis cohort of Mexican patients with BS showed a predominance of female sex, joint involvement phenotype, frequent relapses, and favorable outcomes. Differences in comorbidities and clinical manifestations were identified according to sex.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical Characteristics and Outcomes of Mexican Patients With Behçet’s Syndrome

Hinojosa-Azaola,

Ramírez-Mulhern,

Figueroa-Pariente

et al. 2023

J Clin Rheumatol

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“…Following a round table discussion that took place in the 19th International Conference on BD in Athens, in July 2022 [11], we herein aim in this position paper to delineate the challenges and facilitators for the development and implementation of a T2T approach in BD.…”

Section: Introductionmentioning

confidence: 99%

Treat to target in Behcet's disease: Should we follow the paradigm of other systemic rheumatic diseases?

Fragoulis¹,

Βertsias²,

Bodaghi³

et al. 2023

Clinical Immunology

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“…Oral and genital ulcers are the first and most common manifestations, although recurrent attacks, including mucocutaneous tissues, eyes, and joints are also present with a relatively high frequency (Hatemi et al., 2020). Several complications, such as central nervous system and gastrointestinal tract involvement (Takeuchi, 2021), are less frequent but can be life threatening (Davatchi, 2018; Esatoglu et al., 2018; Gül, 2015; Hatemi et al., 2019; Houman & Bel Feki, 2014). The pathogenesis of BD is complex and still remains unclear (Greco et al., 2018; Leccese & Alpsoy, 2019).…”

Section: Introductionmentioning

confidence: 99%

Interleukin‐21 receptor gene polymorphism (rs2285452 A/G) is associated with susceptibility to Behçet's disease

Lahmar

Chabchoub

Zemni

et al. 2023

Int J Immunogenetics

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Behçet's disease (BD) is a chronic auto inflammatory disorder of unknown aetiology.Recently, the dysregulation of interleukin-21 receptor (IL-21R) has been incriminated in different autoimmune and auto-inflammatory diseases, such as systemic lupus erythematous, rheumatoid arthritis, and type 1 diabetes. Herein, we aimed to investigate the association of two Il-21R gene polymorphisms with BD. IL-21R rs2214537 and IL-21R rs2285452 genotypings were investigated in a cohort of 110 adult patients with BD and 116 age and gender unmatched healthy controls. Genotyping was performed by mutagenically separated polymerase chain reaction with newly designed primers. IL-21R rs2285452 genotypes and alleles distribution were statistically different between patients with BD and controls. GA and AA genotypes carrying the minor A allele were more frequent in patients with BD than in healthy controls (37.3% and 11.8% vs. 23.3% and 3.4%, respectively). The minor A allele was associated with an increased BD risk (odds ratios = 2.42, 95% confidence interval = 1.214.87, p = .005).IL-21R rs2214537 GG genotype was found to be associated with susceptibility to BD in the recessive model (GG vs. CC + CG; p = .046, OR = 1.91, 95% CI = 1.003.650. IL-21R rs2285452 and IL-21R rs2214537 were not in linkage disequilibrium (D' = 0.42).The AG haplotype was more frequently observed in patients with BD than in controls (0.247 vs. 0.056, p = .0001). This study for the first time reports the association of IL-21R rs2285452 and IL-21R rs2214537 with BD. Functional studies are required to elucidate the exact role of these genetic variants.

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Highlights of the 19th International Conference on Behçet's Syndrome

Cited by 5 publications

References 5 publications

Clinical Characteristics and Outcomes of Mexican Patients With Behçet’s Syndrome

Clinical Characteristics and Outcomes of Mexican Patients With Behçet’s Syndrome

Treat to target in Behcet's disease: Should we follow the paradigm of other systemic rheumatic diseases?

Interleukin‐21 receptor gene polymorphism (rs2285452 A/G) is associated with susceptibility to Behçet's disease

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