Highlights on Advancing Frontiers in Tissue Engineering

Ashammakhi, Nureddin; GhavamiNejad, Amin; Tutar, Rumeysa; Fricker, Annabelle T. R.; Roy, Ipsita; Chatzistavrou, Xanthippi; Apu, Ehsanul Hoque; Nguyen, Kim‐Lien; Ahsan, Tabassum; Pountos, Ippokratis; Caterson, Edward J.

doi:10.1089/ten.teb.2021.0012

Cited by 77 publications

(36 citation statements)

References 411 publications

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“…122 OoC technology represents an advancing frontier for in vitro modeling and testing. 5,108,110 OoC allows the use of specific organ and tissue models of normal and disease states, 123 and therefore, it will potentially allow more specific testing of MENPs for defined applications. In addition, the use of patient's own cells (differentiated or stem cells) will enable the development of individualized 124 tailored regimes of use of MENPs in the future.…”

Section: Future Directionsmentioning

confidence: 99%

“…[1][2][3] NPs have also been used to advance tissue engineering, regenerative medicine, and stem cell biology by developing an effective cell/tissue-biomaterial interface to support biological functions. 1,4,5 In particular, particles with both magnetic and electric properties have attracted specific interest because of the tremendous potential for targeted drug delivery and control of biological functions. For example, superparamagnetic iron oxide has been extensively used as a T 2 -weighted magnetic resonance imaging (MRI) contrast agent.…”

Section: Introductionmentioning

confidence: 99%

“…11 Magnetic NPs have been used as the actuator influenced by alternating magnetic field application, where magnetic levitation utilizes a magnetic force to levitate cultured cells mixed with magnetic NPs, or as a method of site-specific heating. 5 Piezoelectric materials can be used to fabricate NPs and are also able to generate an electrical charge upon mechanical pressure, and can thus be used to influence biology through modulation with external sources via electro-mechanical transduction. 12,13 Piezoelectricity is the phenomenon by which mechanical energy is converted to electrical energy and vice versa.…”

Section: Introductionmentioning

confidence: 99%

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Biomedical applications of multifunctional magnetoelectric nanoparticles

Apu

Nafiujjaman

Sandeep

et al. 2022

Mater. Chem. Front.

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Section: Future Directionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biomedical applications of multifunctional magnetoelectric nanoparticles

Apu

Nafiujjaman

Sandeep

et al. 2022

Mater. Chem. Front.

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“…3 The horizon of tissue engineering (TE) is being extensively investigated nowadays and considered to serve as a substitute solution in addressing challenges for future bone regeneration and repair in clinical applications. 4 Tissue engineering aims at fabricating bone grafts with good mechanical properties, biodegradability, osteogenic potency, and biocompatibility comparable with that of the natural bone extracellular matrix (ECM).…”

Section: Introductionmentioning

confidence: 99%

Enhancing physicochemical, mechanical, and bioactive performances of monetite nanoparticles reinforced chitosan‐PEO electrospun scaffold for bone tissue engineering

Singh

Mishra

Gupta

et al. 2022

J of Applied Polymer Sci

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In the current work, monetite (DCPA) nanoparticles incorporated chitosan (CH)‐based composite was prepared using by electrospinning technique. A smooth and defect‐free fibrous matrix with an average fiber diameter in the range between 311 ± 13 to 380 ± 28 nm was obtained for 5 wt% (CH‐DCPA5) and 7 wt% DCPA (CH‐DCPA7) containing electrospun scaffolds. The results indicated that the addition of 7 wt% DCPA nanoparticles to chitosan caused an increase in the tensile strength of scaffolds from 6.2 to 12.34 MPa. A slow degradation rate (~37% in 28 days) indicates its suitability for bone tissue regeneration. A study on the biomineralization capability of the electrospun scaffolds after their immersion in simulated body fluid in vitro revealed that the addition of DCPA strongly promoted the deposition of the apatite layer onto electrospun nanofibrous scaffolds. The culture of MG‐63 osteoblast cells on the scaffolds demonstrated that the incorporation of DCPA nanoparticles into the chitosan polymeric matrix helped in the adhesion, spreading, and migration of cells. CH‐DCPA5 and CH‐DCPA7 scaffolds exhibited a higher capacity to proliferate osteoblast cell lines as compared to pure CH scaffold as confirmed by MTT assay and qualitative cell viability analysis from fluorescence microscopy. Immunocytochemistry analysis for osteocalcin expression revealed a higher capacity of DCPA‐containing scaffolds to differentiate MG‐63 cells into bone lineage as compared to pure chitosan scaffolds. DCPA incorporation into chitosan also resulted in MG‐63 cultured on to it to elicit higher alkaline phosphatase activity suggesting the highest capacity of CH‐DCPA7 to differentiate MG 63 cell line among all the scaffolds studied here. The results indicated superior osteogenic properties of DCPA nanoparticle reinforced chitosan matrix for use in BTE in the form of nanofibrous scaffolds.

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“…Tissue engineering is an area in which biomedical research is investing heavily [ 21 , 22 ]. Tissue engineering represents an alternative to autologous grafts.…”

mentioning

confidence: 99%