Highlights on Chaetomium morphology, secondary metabolites and biological activates

Elkhateeb, Waill A

doi:10.31579/2693-7247/033

Cited by 6 publications

(6 citation statements)

References 40 publications

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“…These compounds were identi ed as acetyl tributyl citrate (ATBC) at a concentration of 35.29%, 2,4-ditert-butylphrenol (2,4-DBP) at 13.4%, 1hexadecanol at 8.35%, 1-nonadecene at 5.67%, decanedioic acid, dibutyl ester at 4.4%, and 7-hexadecane at 4.18%. Consistent with the ndings of Elkhateeb et al (2021), the analysis of the crude extract of Chaetomium sp. by (GC-MS) revealed the presence of several compounds with bioactive properties, including antimicrobial and antioxidant compounds.…”

Section: Discussionsupporting

confidence: 83%

Endophyte Chaetomium, Potential Bioactivity: Pharmaceutical and Phytochemical Analyses

Kheiralla,

Abo-Ghalia,

Elaasser

et al. 2023

Preprint

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Endophytic fungi establish mutualistic symbiotic relationships with plants, wherein their interactions facilitate the production of bioactive secondary metabolites by the fungal cells. The objective of this study is to examine the antioxidative, anticancer, cytotoxic, and antiviral properties of crude metabolites from the fungal endophytes Chaetomium laterale LC4146 and Chaetomium interruptum CBS126660. Chromatographic separation and metabolic main chemical identification were also addressed. Semi-purified extracts showed radical-inhibiting or 2,2-diphenyl-1-picrylhydrazyl-radical-scavenging capabilities. The crude ethyl acetate extract of C. interruptum has the highest inhibitory activity against human liver (HepG2), prostate (PC-3), and colorectal (HCT-116) cancer cells and interestingly shows low toxicity to normal Vero African Green Monkey kidney cells. Fungi extract exerted dose-dependent anticancer effects on three cancer cell lines, with observable alterations in the shape and morphology of HepG2 cells under an inverted microscope. To test the in vitroanti- Herpes Simplex Virus type-1 (HSV-1) efficiency of ethyl acetate and petroleum ether extracts, the cytopathic effect inhibition was weak to moderate. Phytochemical examination of fungal extracts revealed phenolics, esters, alcohols, and hydrocarbons. Hexanedioic acid, 2,4-ditert-butylphenol, 1,2-benzene dicarboxylic acid, and 1-hexadecanol are the most bioactive successful chemicals. Since these unique bioactive components of fungal extract were acceptable in vitro, the two Chaetomium species may be a viable source of natural products and a good starting point for medicinal applications.

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Section: Discussionsupporting

confidence: 83%

Endophyte Chaetomium, Potential Bioactivity: Pharmaceutical and Phytochemical Analyses

Kheiralla,

Abo-Ghalia,

Elaasser

et al. 2023

Preprint

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“…All previous studies indicate to significant ability of A. jodhpurensis in biological control of several plant pathogens besides its medical and industrial applications [39,40,41]. However, in the current study, A. jodhpurensis fungus was found to be pathogenic causing root rot disease on pepper plant.…”

Section: B Acontrasting

confidence: 61%

First Report of Acrophialophora jodhpurensis Causing Root Rot and Seedling Damping-Off of Pepper (Capsicum annum L.) in Karbala Province, Iraq

Khudier,

Abdalmoohsin

2023

IOP Conf. Ser.: Earth Environ. Sci.

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Pepper is an important vegetable crop in Iraq and worldwide. During a survey conducted in 2022 in Karbala Province, Iraq, an epidemic root rot disease affecting pepper plants was observed. Based on morphological appearances, pathogenicity assessment and rDNA-ITS sequence analyses, the fungal causing this disease was identified as Acrophialophora jodhpurensis (OQ102241.1). To best of our knowledge, this is the first record of A. jodhpurensis fungus causing root rot on pepper crop in Karbala, Iraq.

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“…Over 200 compounds with a broad range of bioactive effects have been isolated from Chaetomium sp. so far (Table 1) (Elkhateeb et al 2021), yet more bioactive secondary metabolites can potentially be found.…”

Section: Introductionmentioning

confidence: 99%

Key insights into secondary metabolites from various Chaetomium species

Dwibedi

Rath

Jain

et al. 2023

Appl Microbiol Biotechnol

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Endophytic fungi have proved to be a major source of secondary metabolites, wherein the genus Chaetomium has emerged as a source of multifarious bioactive natural compounds belonging to diverse classes such as chaetoglobosins, epipolythiodioxopiperazines, azaphilones, xanthones, anthraquinone, chromones, depsidones, terpenoids, and steroids. The objective of this review is to encapsulate recent findings on various Chaetomium strains, such as C. globosum , C. cupreum , C. elatum , C. subspirale , C. olivaceum , C. indicum , and C. nigricolor known for production of beneficial secondary metabolites, with an insight into their origin and function. A thorough literature survey was conducted for obtaining Chaetomium -derived secondary metabolites, with a scope of future application into drug development efforts. More than 100 secondary metabolites, with various beneficial properties such as antitumor, cytotoxic, antimalarial, and enzyme inhibitory activities, were enlisted. We believe this review will enhance the understanding of beneficial effects conferred by various Chaetomium -derived secondary metabolites and emphasize their potential in serving novel drug development efforts. Key points • Identified Chaetomium - derived metabolites with potential for drug development. • More than 100 beneficial metabolites are enlisted. • Benefits include anti-cancerous, antimalarial, and anti-enzymatic properties . Graphical Abstract

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Highlights on Chaetomium morphology, secondary metabolites and biological activates

Cited by 6 publications

References 40 publications

Endophyte Chaetomium, Potential Bioactivity: Pharmaceutical and Phytochemical Analyses

Endophyte Chaetomium, Potential Bioactivity: Pharmaceutical and Phytochemical Analyses

First Report of Acrophialophora jodhpurensis Causing Root Rot and Seedling Damping-Off of Pepper (Capsicum annum L.) in Karbala Province, Iraq

Key insights into secondary metabolites from various Chaetomium species

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