Highly active and selective telechelic antimicrobial poly(2-oxazoline) copolymers

Krumm, Christian; Hijazi, Montasser; Trump, Sylvia; Saal, Simon; Richter, Lena; Noschmann, Gottfried Georg Franz Konrad; Nguyen, Thanh-Duong; Preslikoska, Kristina; Moll, Thorsten; Tiller, Joerg C.

doi:10.1016/j.polymer.2017.04.074

Cited by 13 publications

(16 citation statements)

References 40 publications

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“…[11a] The activities against S. aureus are somewhat weaker than previously reported telechelic POx, which show MIC values as low as 1 µg mL −1 , which places them among the most active known antimicrobial polymers. [8a] In contrast to the polymers above they show the strong satellite group effect due to the optimal ratio between the starter group and the distal quaternary ammonium end group, which means that the satellite group has to have a shorter hydrophobic moiety than those of the quat. POx with similar end groups does not possess this optimal ratio and are therefore less active.…”

Section: Resultsmentioning

confidence: 99%

“…Telechelic antimicrobial polymers have proven themselves as reliable agents to fight pathogenic bacterial strains. Representatives of this kind of antimicrobial polymers are poly(2‐oxazoline)s, which can act as polymeric spacers for antimicrobial surfaces or as water‐soluble biocides . They were equipped with a biocidal end group and a second non‐biocidal group that introduced the possibility to control or switch their antimicrobial activity over several orders of magnitude.…”

Section: Introductionmentioning

confidence: 91%

“…They were equipped with a biocidal end group and a second non‐biocidal group that introduced the possibility to control or switch their antimicrobial activity over several orders of magnitude. [8b,11] This was observed for Gram‐positive strains, e.g., Staphylococcus aureus . Poly(2‐oxazoline)s with quaternary ammonium end groups are hardly active against Gram‐negative bacterial strains, such as Escherichia coli .…”

Section: Introductionmentioning

confidence: 91%

“…Biocidal polymers are divided into three main groups such as biocide releasing polymers, polymerized biocides, and biocidal polymers . The latter ones can be subdivided in amphiphilic polycations, telechelic biocidal polymers, and hydrophilic polycations . Telechelic antimicrobial polymers have proven themselves as reliable agents to fight pathogenic bacterial strains.…”

Section: Introductionmentioning

confidence: 99%

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Telechelic, Antimicrobial Hydrophilic Polycations with Two Modes of Action

Richter

Hijazi

Arfeen

et al. 2018

Macromolecular Bioscience

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Telechelic antimicrobial poly(2-oxazoline)s with quaternary ammonium (quat) end groups are shown to be potent antimicrobial polymers against Gram-positive bacterial strains. In this study, the activity against the Gram-negative bacterium Escherichia coli is additionally implemented by hydrolyzing the poly(2-methyl-2-oxazoline) with two quart end groups to poly(ethylene imine) (PEI). The resulting telechelic polycations are active against Staphylococcus aureus and E. coli. The contribution of the PEI backbone is determined by measuring the antimicrobial activity in the presence of calcium ions. The influence of PEI on the overall activity strongly depends on the molecular weight and increases with higher mass. The PEI dominates the activity against E. coli at lower masses than against S. aureus. The quart end groups require an alkyl substituent of dodecyl or longer to dominate the antimicrobial activity. Additionally, PEI and quart end groups act synergistically.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Telechelic, Antimicrobial Hydrophilic Polycations with Two Modes of Action

Richter

Hijazi

Arfeen

et al. 2018

Macromolecular Bioscience

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“…In addition, PEOX has been reported with good adhesion on different surfaces including aluminum foil, nylon, poly(methyl methacrylate) (PMMA), and polyvinyl alcohol (PVA) [ 13 ]. Furthermore, due to its low cytotoxicity and “living polymerization” characteristic, PEOX has been applied in electronic devices [ 14 , 15 ] biomedical applications including drug delivery [ 16 ], anti-fouling coatings individually or as a monomer of block copolymers [ 17 , 18 , 19 ]. PEOX can also be adopted as a coating material because of its good light stability and re-solubility [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Environment-Friendly Poly(2-ethyl-2-oxazoline) as an Innovative Consolidant for Ancient Wall Paintings

Zhang

Wei

2018

Nanomaterials

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The research of innovative materials on the conservation of ancient wall paintings has given rise to increased attention in recent years. One of the most used synthetic organic consolidation material for the wall paintings is the commercial acrylic resin Paraloid B72 (PB 72), which encounters problems of the use of toxic solvents, low water vapor transmission, and poor penetration. Here, the non-toxic, environment-friendly product poly(2-ethyl-2-oxazoline) (PEOX) has been demonstrated as a great potential consolidant for wall paintings to solve these issues. First of all, thanks to the better penetration ability, the simulating plaster sample treated with PEOX shows greater enhanced surface hardness than PB 72. The single-lap joint shear strength test and the scotch tape test revealed the good adhesion of PEOX on inorganic surfaces and effective pigment consolidation. At the same time, the PEOX-treated sample presents less surface gloss. The hydrophilic nature of PEOX merits itself with superior water vapor permeability compared with PB 72. These advantages enable PEOX to be a progressive choice to replace the use of PB 72 in the controlled indoor working environment.

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