Highly active antiretroviral therapy-silver nanoparticle conjugate interacts with neuronal and glial cells and alleviates anxiety-like behaviour in streptozotocin-induced diabetic rats

Lawal, Sodiq Kolawole; Olojede, Samuel Oluwaseun; Dare, Ayobami; Faborode, Oluwaseun Samuel; Sulaiman, Sheu Oluwadare; Naidu, Edwin Coleridge Stephen; Rennie, Carmen Olivia; Azu, Onyemaechi Okpara

doi:10.1016/j.ibneur.2022.06.003

Cited by 1 publication

(7 citation statements)

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“…In contrast, it was observed that while TDF administration did not alter the Malondialdehyde (MDA, a marker of lipid peroxidation) and interleukin-1 beta (IL-1β, a proinflammatory cytokine) in the prefrontal cortex of normal rats, TDF increased MDA and IL-1β levels in the prefrontal cortex of diabetic rats when compared to rats that did not receive TDF (S. Lawal et al, 2022a). In the same study, an ultrastructural assessment of the Frontiers in Pharmacology frontiersin.org prefrontal cortex revealed that diabetic rats that received TDF had reduced GFAP-positive astrocytes and increased mitochondrial damage (S. Lawal et al, 2022b).…”

Section: Antiretroviral Drugs Associated With Neurological Disordersmentioning

confidence: 94%

“…In another study by Lawal and colleagues, they also found that the administration of Tenofovir disoproxil fumarate (TDF) alone did not alter working memory in rats as tested in Y-maze. However, TDF administration worsened the working memory of diabetic rats (S. Lawal et al, 2022b).…”

Section: Antiretroviral Drugs Associated With Neurological Disordersmentioning

confidence: 99%

Section: Silver Nanoparticles As An Antidiabetic Agentmentioning

confidence: 99%

“…On the contrary, AgNPs + HAART show a better output by preventing HIV replication with reduced neurocognitive disorders. Adapted from ( Lawal et al, 2022a ; Lawal et al, 2021 ; Lawal et al, 2022b ).…”

Section: Introductionmentioning

confidence: 99%

“…A similar study revealed that AgNPs possess antidiabetic activity by showing maximum inhibition of α-amylase at 78.84% and α-glucosidase at 58.86% at 100 μg/ml concentration (R and Scleeva P 2021). Several studies have reported that small-medium biosynthesised AgNPs control glycaemic index by significantly reducing the blood glucose levels in experimental rats ( Agarwal et al, 2018 ; Alkaladi et al, 2014 ; S. Lawal et al, 2022b ; Lawal et al, 2021 ). The mechanism of action of AgNPs on glycaemic control is linked with an increase in insulin secretion, which enhances hepatic glycogenesis and a significant increase in the expression of GLUT-2 levels in hepatic tissues ( Alkaladi et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Nanodelivery of antiretroviral drugs to nervous tissues

et al. 2022

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Despite the development of effective combined antiretroviral therapy (cART), the neurocognitive impairments associated with human immunodeficiency virus (HIV) remain challenging. The presence of the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCFB) impedes the adequate penetration of certain antiretroviral drugs into the brain. In addition, reports have shown that some antiretroviral drugs cause neurotoxicity resulting from their interaction with nervous tissues due to long-term systemic exposure. Therefore, the research into the effective therapeutic modality that would cater for the HIV-associated neurocognitive disorders (HAND) and ART toxicity is now receiving broad research attention. Thus, this review explores the latest information in managing HAND using a nanoparticle drug delivery system (NDDS). We discussed the neurotoxicity profile of various approved ART. Also, we explained the applications of silver nanoparticles (AgNPs) in medicine, their different synthesis methods and their interaction with nervous tissues. Lastly, while proposing AgNPs as useful nanoparticles in properly delivering ART to enhance effectiveness and minimize neurocognitive disorders, we hypothesize that the perceived toxicity of AgNPs could be minimized by taking appropriate precautions. One such precaution is using appropriate reducing and stabilizing agents such as trisodium citrate to reduce silver ion Ag + to ground state Ag0 during the synthesis. Also, the usage of medium-sized, spherical-shaped AgNPs is encouraged in AgNPs-based drug delivery to the brain due to their ability to deliver therapeutic agents across BBB. In addition, characterization and functionalization of the synthesized AgNPs are required during the drug delivery approach. Putting all these factors in place would minimize toxicity and enhance the usage of AgNPs in delivering therapeutic agents across the BBB to the targeted brain tissue and could cater for the HIV-associated neurocognitive disorders and neurotoxic effects of antiretroviral drugs (ARDs).

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Section: Antiretroviral Drugs Associated With Neurological Disordersmentioning

confidence: 94%

Section: Antiretroviral Drugs Associated With Neurological Disordersmentioning

confidence: 99%