Highly Active Antiretroviral Therapy-silver Nanoparticle Conjugate Alleviates Anxiety-like Behaviour in Streptozotocin-induced Diabetic Rats

Lawal, Sodiq Kolawole; Olojede, Samuel Oluwaseun; Dare, Ayobami; Faborode, Oluwaseun Samuel; Naidu, Edwin Coleridge Stephen; Rennie, Carmen Olivia; Azu, Onyemaechi Okpara

doi:10.21203/rs.3.rs-1025387/v1

Cited by 2 publications

(2 citation statements)

References 63 publications

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“…Nissl body will change due to changes in the physiological state. When neurons are stimulated, the Nissl bodies in the cell body will be significantly reduced (Lawal et al, 2021). Therefore, Nissl staining in brain sections was utilized to examine whether the neurons were damaged or not.…”

Section: Histopathological Staining and Nissl Staining Results Of Hip...mentioning

confidence: 99%

Obese mice induced by high-fat diet have differential expression of circular RNAs involved in endoplasmic reticulum stress and neuronal synaptic plasticity of hippocampus leading to obesity-associated cognitive impairment

Yan¹,

Pan

Liu³

et al. 2022

Front. Mol. Neurosci.

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Obesity induced by a high-fat diet (HFD) is an important cause of impaired memory and cognitive function, but the underlying mechanisms are not clear. In the present study, we analyzed the levels of circRNAs in the hippocampus of C57BL/6J mice and evaluated the memory and cognition ability of C57BL/6J mice with HFD using Morris water maze and Y-maze approaches to explore the potential mechanisms linking circRNAs in obesity-associated cognitive impairment. Learning performance showed that HFD-induced obesity mice have impaired memory and cognition. The Arraystar analysis of the hippocampus displayed that HFD-induced obesity leads to the differential expression of circRNAs (DE-circRNAs) in mice. In total, 46 circular RNAs with elevated expression and 10 with decreased expression were identified. Among them, mmu_circRNA_004797 was identified to be significantly downregulated and the expression of mmu_circRNA_21040 was significantly upregulated in the HFD-fed mice, compared with control mice by PCR test. Bioinformatics analysis also showed that the upregulated circRNAs were related to the neuronal function and behavior, and material transport process, while downregulated circRNAs participated in the process of cell response to external stimuli, such as cellular response to nutrient levels. Furthermore, the KEGG pathway analysis showed that the upregulated circRNAs are mainly involved in Axon guidance, calcium signaling pathway, and ErbB signaling pathway. Only a single significant pathway, that is, “protein processing in endoplasmic reticulum”, was observed in the downregulated circRNAs. Finally, we examined the deficits of hippocampal synaptic plasticity and detected the expression of ER stress-related protein. The results showed that ER stress was activated in the hippocampus, and hippocampal synaptic plasticity deficits were displayed. Our results demonstrated that circRNAs were most likely implicated in the predisposition to obesity-associated cognitive impairment.

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Section: Histopathological Staining and Nissl Staining Results Of Hip...mentioning

confidence: 99%

Obese mice induced by high-fat diet have differential expression of circular RNAs involved in endoplasmic reticulum stress and neuronal synaptic plasticity of hippocampus leading to obesity-associated cognitive impairment

Yan¹,

Pan

Liu³

et al. 2022

Front. Mol. Neurosci.

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“…Due to the widespread use of antiretroviral drugs (ARVs), the global prevalence of dyslipidemia in HIV-infected patients has accelerated. As patients are required to take ARVs for the rest of their lives, hyperlipidemia is becoming a real concern, putting them in a condition of ongoing lipid derangement, which further leads to cardiovascular disease and atherosclerosis 8,9 . In Uganda, 58% of patients on first-line Active ART had metabolic syndrome, observed more in women than men 10 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of dyslipidemias in human immunodeficiency virus-infected patients with and without antiretroviral therapy.

Chaudhary

Farhan

Zeeshan

et al. 2022

Int. j. endorsing health sci. res.

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Background: Disturbances in the lipid profile and dyslipidemia are prevalent among human immunodeficiency virus (HIV) patients. Furthermore, long-term use of antiretroviral therapy (ART) exacerbates the condition. Data on lipid profile abnormalities among patients receiving highly active antiretroviral treatment in Pakistan are very limited. The present study aims to assess the frequency of dyslipidemia and lipid concentrations among HIV-infected patients receiving active art in comparison to those not receiving any treatment. Methodology: A cross-sectional study was carried out at the HIV clinic of Pakistan Institute of Medical Sciences, Islamabad, from January to July 2018. A total of 100 HIV-infected patients aged 13 to 60 years who gave consent and fulfilled the inclusion criteria were enrolled in the study via non-probability consecutive sampling. All patients who had positive HIV antibodies via the Elisa process were considered positive. Samples were examined for fasting lipids by using standard laboratory procedures. Results: The patients' mean age was 32.7 ± 13.4 ranging between 13-60 years. The total patient population consisted of 71% males and 29% females with a mean BMI of 21.1 ± 3.4 kg/m2. Out of 100, 38% of the study patients had dyslipidemia. The observed prevalence rate of hypertriglyceridemia, hypercholesterolemia, low HDL-C, and high LDL-C were 21%, 30%, 20%, and 16%, respectively. None of the factors were found in significant association with abnormal lipid parameters except the older patients (41-60 years) were at higher risk of hypercholesterolemia [aOR 0.15 (95% CI 0.02-0.92); p=0.04] than the counterpart. Conclusion: The study has demonstrated that a higher percentage of HIV-infected patients have concomitant dyslipidemia with or without art treatment.

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Highly Active Antiretroviral Therapy-silver Nanoparticle Conjugate Alleviates Anxiety-like Behaviour in Streptozotocin-induced Diabetic Rats

Cited by 2 publications

References 63 publications

Obese mice induced by high-fat diet have differential expression of circular RNAs involved in endoplasmic reticulum stress and neuronal synaptic plasticity of hippocampus leading to obesity-associated cognitive impairment

Obese mice induced by high-fat diet have differential expression of circular RNAs involved in endoplasmic reticulum stress and neuronal synaptic plasticity of hippocampus leading to obesity-associated cognitive impairment

Prevalence of dyslipidemias in human immunodeficiency virus-infected patients with and without antiretroviral therapy.

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