Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications

Abstract

Cranberry is a fruit originally from New England and currently growing throughout the east and northeast parts of the USA and Canada. The supplementation of cranberry extracts as nutraceuticals showed to contribute to the prevention of urinary tract infections, and most likely it may help to prevent cardiovascular and gastroenteric diseases, as highlighted by several clinical trials. However, aiming to validate the efficacy and safety of clinical applications as long-term randomized clinical trials (RCTs), further investigations of the mechanisms of action are required. In addition, a real challenge for next years is the standardization of cranberry’s polyphenolic fractions. In this context, the optimization of the extraction process and downstream processing represent a key point for a reliable active principle for the formulation of a food supplement. For this reason, new non-conventional extraction methods have been developed to improve the quality of the extracts and reduce the overall costs. The aim of this survey is to describe both technologies and processes for highly active cranberry extracts as well as the effects observed in clinical studies and the respective tolerability notes.

Microbiome and metabolome analysis to clarify the interaction between the urine microbiota and serum metabolites in Chinese patients with immunoglobulin A nephropathy

“…Some probiotics, such as Lactobacillus , have been shown to inhibit the synthesis of TMAO, reducing inflammatory signaling and improving renal function in CKD ( 56 , 57 ). Some studies suggest that D-mannose can inhibit bacterial adherence to uroepithelial cells ( 58 , 59 ). We speculate that Lactobacillus and D-mannose may work together to aid urethral immunity.…”

O Papel Do Arando Na Prevenção Das Infeções Do Trato Urinário: Uma Revisão Narrativa Da Literatura

“…São numerosos os estudos realizados in vitro que asseguram a eficácia do arando na prevenção das ITU. Estes fundamentam-se na composição específica do fruto em protoantocianidinas (PAC) e na capacidade destas em inibir a adesão das bactérias aos recetores das células uroepiteliais, interagindo com as fímbrias-p (a-galactose-1-4) das estirpes bacterianas da E.coli (1,13,14,17,20,21) e com a superfície e virulência da Helicobacter pylori (14,21,22).…”

Therapeutic potential of cranberry for kidney health and diseases

“…They also contain soluble fibers, which is why excessive consumption can cause diarrhea (Zhao et al, 2020). Cranberries also contain bioactive compounds and antioxidants, especially flavonoids (Colletti et al, 2021). Most of these are concentrated in the peel and are reduced by the preparation of cranberry juice.…”