Highly anisotropic and elastic cellulosic scaffold guiding cell orientation and osteogenic differentiation via topological and mechanical cues

Liu, Kun; He, Xiangheng; Zhang, Zhaoyu; Sun, Tianyi; Chen, Jiaqing; Chen, Chunhua; Wen, Wei; Ding, Shan; Zhou, Changren; Luo, Binghong

doi:10.1016/j.carbpol.2023.121292

Carbohydrate Polymers

2023

DOI: 10.1016/j.carbpol.2023.121292

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Highly anisotropic and elastic cellulosic scaffold guiding cell orientation and osteogenic differentiation via topological and mechanical cues

Kun Liu

Xiangheng He

Zhaoyu Zhang

et al.

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2024

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Cited by 4 publications

References 45 publications

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A Wood‐Derived Periosteum for Spatiotemporal Drug Release: Boosting Bone Repair through Anisotropic Structure and Multiple Functions

Sun,

Chen,

Liu

et al. 2024

Adv Healthcare Materials

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Existing artificial periostea face many challenges, including difficult‐to‐replicate anisotropy in mechanics and structure, poor tissue adhesion, and neglected synergistic angiogenesis and osteogenesis. Here, inspired by natural wood (NW), a wood‐derived elastic artificial periosteum is developed to mimic the structure and functions of natural periosteum, which combines an elastic wood (EW) skeleton, a polydopamine (PDA) binder layer, and layer‐by‐layer (LBL) biofunctional layers. Specifically, EW derived from NW is utilized as the anisotropic skeleton of artificial periosteum to guide cell directional behaviors, moreover, it also shows a similar elastic modulus and flexibility to natural periosteum. To further enhance its synergistic angiogenesis and osteogenesis, surface LBL biofunctional layers are designed to serve as spatiotemporal release platforms to achieve sequential and long‐term release of pamidronate disodium (PDS) and deferoxamine (DFO), which are pre‐encapsulated in chitosan (CS) and hyaluronic acid (HA) solutions, respectively. Furthermore, the combined effect of PDA coating and LBL biofunctional layers enables the periosteum to tightly adhere to damaged bone tissue. More importantly, this novel artificial periosteum can boost angiogenesis and bone formation in vitro and in vivo. This study opens up a new path for biomimetic design of artificial periosteum, and provides a feasible clinical strategy for bone repair.

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A Wood‐Derived Periosteum for Spatiotemporal Drug Release: Boosting Bone Repair through Anisotropic Structure and Multiple Functions

Sun,

Chen,

Liu

et al. 2024

Adv Healthcare Materials

Self Cite

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Developing fibrin-based biomaterials/scaffolds in tissue engineering

Li,

Dan,

Chen

et al. 2024

Bioactive Materials

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Wood-inspired highly anisotropic scaffold activated with in situ mineralized collagen for advanced bone regeneration

Wang,

Chen,

Guo

et al. 2024

Chemical Engineering Journal

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Highly anisotropic and elastic cellulosic scaffold guiding cell orientation and osteogenic differentiation via topological and mechanical cues

Cited by 4 publications

References 45 publications

A Wood‐Derived Periosteum for Spatiotemporal Drug Release: Boosting Bone Repair through Anisotropic Structure and Multiple Functions

A Wood‐Derived Periosteum for Spatiotemporal Drug Release: Boosting Bone Repair through Anisotropic Structure and Multiple Functions

Developing fibrin-based biomaterials/scaffolds in tissue engineering

Wood-inspired highly anisotropic scaffold activated with in situ mineralized collagen for advanced bone regeneration

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