Highly Antibacterial and Adhesive Hyaluronic Acid Hydrogel for Wound Repair

Abstract

Bacterial infections accompanied with wound healing often lead to more serious health hazards to patients. Therefore, it is urgent to explore a wound dressing that can promote wound repair while possessing antibacterial capability. Here, we constructed a multifunctional hydrogel dressing by a redox-initiated cross-linking reaction of methacrylated hyaluronic acid (HAMA), 5,10,15,20-tetra (4-methacrylate phenyl) porphyrin (TPP), and dopamine methacrylamide (DMA), named HAMA-TPP-DMA, with broad-spectrum photodynamic antibacterial capability, where the aggregation of TPP photosensitizer units could be greatly inhibited to produce more singlet oxygen. The hydrogel has excellent biodegradability and biocompatibility, providing favorable conditions for wound healing. Furthermore, the incorporation of dopamine into the hydrogel gives the wound dressing with enhanced adhesiveness, benefiting for the wound repair. More importantly, the antibacterial experiments in vitro and mice wound models in vivo showed that the HAMA-TPP-DMA hydrogel can significantly resist bacteria and accelerate the wound healing in mice (the closure rate > 98% after 15 days). Thus, this hydrogel dressing with superior antibacterial infection and wound healing capability provides a promising strategy in wound repair.

A cooling-driven self-adaptive and removable hydrogel coupled with combined chemo-photothermal sterilization for promoting infected wound healing

“…The hydrogel dressing with tissue adhesion facilitates to seal the wound to provide a favorable milieu for healing. 39–41 As shown in Fig. 3(c), the rGO@PDA/Ag-PF127-3 hydrogel could adhere tightly to the knuckle and did not dislodge or break even when bent to different angles, which indicated good tissue adhesion and toughness of the hydrogel.…”

Fabrication of an Adhesive Small Intestinal Submucosa Acellular Matrix Hydrogel for Accelerating Diabetic Wound Healing

“…It indicated that the addition of the SISAM had almost no positive or negative effect on the adhesion of the original HN. The tissue adhesive property guaranteed secure fit to wound in the therapeutic process. , Ex vivo , as displayed in Figure F, the SISAM@HN hydrogel formed in situ on the porcine skin could recover to its original state after bending and wrenching, suggesting a desirable tissue binding strength and flexibility as a wound dressing. Further, we evaluated the mechanical properties of the hydrogels (Figure G).…”

Facile Double-Injection Strategy for the Engineering of Versatile Multiresponsive Hydrogels Encapsulating Drug-Loaded Micelles for Promoting Diabetic Wound Healing

“…Clinically, dressings are indispensable in chronic wound care. Hydrogels have been widely used in wound dressing due to their high water content, ductility, similarity to living tissue, and adjustable physicochemical properties. − Note that for diabetes wounds, to well meet the clinical requirements for healing, dressings are designed to handle the special microenvironment including excessive inflammation, ROS accumulation, hyperglycemia, etc. , However, hydrogels used for chronic wounds still have widely acknowledged limitations such as impoverished functions, insufficient cell affinity, and therapeutic effect. Therefore, aiming at the pathological characteristics of diabetes wounds, in addition to the necessary routine care, adjusting the wound microenvironment with hydrogel-based dressings to promote the restoration of wound order is essential for the treatment of diabetes wounds.…”