Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan

Chang, Yi-Jung; Chen, Mi-Chi; Feng, Ye; Su, Lin‐Hui; Li, Hsin-Chieh; Yang, Hsin-Ping; Yu, Min-Jia; Chen, Chyi‐Liang; Chiu, Cheng-Hsun

doi:10.1016/j.pedneo.2020.03.017

Cited by 23 publications

(17 citation statements)

References 26 publications

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“…Furthermore, 34.7% of NTS isolates were multidrug resistance (concomitant resistance to S 3 drug classes of antimicrobials with the same selection) and 5.9% were resistant to ceftriaxone. 22 In the present study, the rates of resistance to firstline antimicrobial agents, namely ampicillin and TMPeSMZ, were also as high as 41% and 20%, respectively. Furthermore, 6% of isolates were not susceptible to ceftriaxone.…”

Section: + Modelsupporting

confidence: 54%

Factors affecting fecal excretion time in pediatric nontyphoid Salmonella infection

Chen

Cheng

et al. 2021

Pediatrics & Neonatology

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Background: This study investigated whether the appropriate antibiotics therapy affects the fecal excretion time in pediatric salmonellosis of different severities and explored the factors associated with the fecal excretion time of nontyphoid Salmonella. Methods: Between 2012 and 2017, admitted children with nontyphoid salmonellosis who consented to receive consecutive stool cultures every 4e7 days until 2 consecutive negative results were obtained were enrolled. Patients were stratified into no, appropriate (bacteremia or severe patients receiving antibiotics active in vitro), and inappropriate antibiotics (patients with mild or moderate severity receiving antibiotics or severe receiving antibiotics resistant in vitro) therapy groups. A previously proposed severity score was used to classify the patients into severe, moderate, and mild severity classes. The demographics, clinical manifestations, laboratory data and severity were compared among the groups. To explore the factors associated with the fecal excretion time of nontyphoid Salmonella, univariate and multivariate analyses were performed using linear regression analysis. Results: This study enrolled 126 children with nontyphoid salmonellosis; 58 and 18 in the mild and severe classes, respectively. The no, appropriate and inappropriate antibiotics therapy groups comprised 69, 24 and 33 patients, respectively. The mean fecal excretion time was 12.17 days. The appropriate antibiotics therapy group had comparable fecal excretion time with that of no antibiotics group. Age <1 year, increased white blood cell count, decreased hemoglobin, and inappropriate antibiotics therapy significantly prolonged fecal excretion time in univariate analysis (p < 0.05). The multivariate analysis showed that inappropriate * Corresponding author. No.386, Dazhong 1st Rd.

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Section: + Modelsupporting

confidence: 54%

Factors affecting fecal excretion time in pediatric nontyphoid Salmonella infection

Chen

Cheng

et al. 2021

Pediatrics & Neonatology

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“…However, the recognition of NTS bacteremia in children before culture is challenging and rarely reported. Furthermore, resistance to antimicrobial agents has increased worldwide, including in Taiwan (Su et al, 2011;James et al, 2018;Chang et al, 2020). Resistant NTS infection has been reported to be correlated with higher morbidity and mortality (Angelo et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Changing Antimicrobial Resistance and Epidemiology of Non-Typhoidal Salmonella Infection in Taiwanese Children

Chang

Chen

et al. 2021

Front. Microbiol.

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Non-typhoidal Salmonella (NTS) typically causes self-limiting diarrheal disease but may occasionally lead to invasive infection. This study investigated the epidemiology and antimicrobial resistance of children with NTS infection between 2012 and 2019. We retrospectively analyzed pediatric patients with NTS infections, confirmed by positive cultures, in a tertiary medical center in Taiwan in 2012 and 2019. Clinical features and laboratory data of the patients were collected. Changes in the serogroup category and antimicrobial resistance were also analyzed. Of the total 797 isolates collected, 55 had NTS bacteremia. Compared with the resistance rates in 2012, the rates of resistances to third-generation cephalosporin and ciprofloxacin were significantly higher in 2019 (4.1% vs 14.3%, P < 0.001; 1.9% vs 28.6%, P < 0.001), especially in groups B, D, and E. Moreover, we observed significantly higher antimicrobial resistance (25.3%) to third-generation cephalosporin, and approximately half the NTS isolates in the infant group were multidrug resistant – a higher rate than those of other age groups in 2019. Invasive NTS often presented with a longer fever duration, lower hemoglobin level and with no elevated C-reactive protein (P < 0.05). Non-invasive NTS isolates in 2019 were significantly more resistant to ceftriaxone (P < 0.001) and ciprofloxacin (P < 0.001) than those in 2012. The antimicrobial resistance of NTS in children has increased progressively in the past decade, and different serogroups exhibited different resistance patterns. During this period, infants showed the highest risk to get a third-generation cephalosporin-resistant NTS infection. The high rates of antimicrobial resistance among children with NTS in Taiwan merit continual surveillance.

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“…The overall percentage of Salmonella spp. resistant to ceftriaxone in the WHO GLASS report for Hong Kong was 5.18% in 2017 ( 25 ) and was similar to the rates of 5.9% (ceftriaxone) in Taiwan ( 26 ), 3% (ceftriaxone) in the United States ( 27 ), and 1.9% (cefotaxime) in Europe ( 21 ). None of the Salmonella spp.…”

Section: Discussionmentioning

confidence: 59%

Genomic Epidemiology of Multidrug-Resistant Nontyphoidal Salmonella in Young Children Hospitalized for Gastroenteritis

et al. 2021

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Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan

Cited by 23 publications

References 26 publications

Factors affecting fecal excretion time in pediatric nontyphoid Salmonella infection

Factors affecting fecal excretion time in pediatric nontyphoid Salmonella infection

Changing Antimicrobial Resistance and Epidemiology of Non-Typhoidal Salmonella Infection in Taiwanese Children

Genomic Epidemiology of Multidrug-Resistant Nontyphoidal Salmonella in Young Children Hospitalized for Gastroenteritis

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