Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis

Zhou, Jun-Su; Cheng, Long; Gao, Yuan; Ge, Zhan-Peng; Zhou, Bin; Li, Jing-Ya; Zhao, Jin-Xin; Yue, Jian-Min

doi:10.1016/j.eng.2023.09.015

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…Several compounds, especially forrestiacids J and K, exhibited notable inhibition of ACLY (IC50: 1.8 to 11µM). Docking studies confirmed strong binding affinities (-9.9 to -10.7 kcal/mol) with ACLY, emphasising their potential therapeutic significance in managing diseases related to ACLY (Zhou et al, 2023).…”

Section: Forres Acidsmentioning

confidence: 81%

ATP-Citrate Lyase (ACLY): An Extensive Investigation from Molecular Insight to Therapeutic implications

Biju,

Chennam Lakshmikumar,

Rengasamy

2024

NRFHH

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ATP Citrate Lyase (ACLY) is a central enzyme bridging carbohydrate metabolism and lipid biosynthesis, crucial for various physiological processes and implicated in numerous pathologies. This review comprehensively describes ACLY, a pivotal enzyme at lipid biosynthesis and cellular metabolism interface. It serves as crucial role for several physiological functions, making it a highly valued topic for research. Starting with a description of the biochemistry and molecular biology of ACLY, elucidating its structural features, functions, and regulatory mechanisms, particularly in lipid synthesis and histone acetylation. Considering the pathophysiological aspect, the review also examines the relationship between ACLY dysregulation and associated diseases, explaining its contribution to pathological conditions mechanistically. An explanation of ACLY inhibitors is as follows: an overview of these inhibitors, an understanding of their mechanisms of action, and an analysis of their effectiveness and specificity. The following sections transition from preclinical studies, summarising key findings and knowledge into therapeutic potential, to clinical trials. The review offers updated information about ACLY research, integrating data from multiple sources to give an in-depth understanding. It concludes with the challenges and outlook facing the developing ACLY inhibitors, considering the strategies to overcome these challenges and the upcoming path in research and development in this promising field. This comprehensive examination not only encapsulates the knowledge at present but also aims to inspire and guide future inquiries into the complex realm of ACLY and its potential as a therapeutic target, ultimately improving patient outcomes and quality of life.

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Section: Forres Acidsmentioning

confidence: 81%

ATP-Citrate Lyase (ACLY): An Extensive Investigation from Molecular Insight to Therapeutic implications

Biju,

Chennam Lakshmikumar,

Rengasamy

2024

NRFHH

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“…The absolute configurations of the compounds 4 , 6 , 8 , and 3-Rb were assigned using time-dependent density functional theory (TDDFT)-ECD calculations (see detailed demonstration in the Supporting Information). − …”

Section: Methodsmentioning

confidence: 99%

Anti-Inflammatory Salicin Derivatives from the Barks of Salix tetrasperma

Wu,

Li,

Ren

et al. 2024

J. Agric. Food Chem.

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The genus Salix L. is traditionally used in folk medicine to alleviate pain caused by various kinds of inflammation. In the present study, 10 undescribed salicin derivatives along with 5 known congeners were isolated from the barks of Salix tetrasperma, and their structures were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, electronic circular dichroism (ECD) calculations, and chemical conversions. Compounds 4−6 significantly inhibited NO production in lipopolysaccharide (LPS)induced RAW 264.7 macrophages, and the most active 4 obviously suppressed the production of IL-1β and IL-6 and decreased iNOS and COX-2 expression in a dose-dependent manner. Further Western blotting analysis revealed that the anti-inflammatory mechanism of 4 is possibly mediated through the MAPK and NF-κB signaling pathways.

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Skeleton Rearranged and Oxygenated ent‐Rosane Diterpenoids with Antiadipogenic Activity from Euphorbia milii

Song,

Guo,

Sun

et al. 2024

Chin. J. Chem.

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Comprehensive SummaryFive unreported and oxygenated ent‐rosane diterpenoids (ent‐RDs), Euphomillanols A—E (1—5), were isolated from Euphorbia milii. Among them, compounds 1 and 2 are unprecedented 7/7/6‐fused tricyclic 5,10‐seco‐ent‐RDs and possess a unique 11‐oxabicyclo[4.4.1]undeca‐1(10),5‐diene moiety, while 3 is characterized by a 1‐methyl‐6‐oxabicyclo[3.2.1]oct‐2‐ene motif of ring A. Their structures with absolute configurations were unambiguously determined by the extensive spectroscopic methods, X‐ray crystallography, and ECD calculation. Putative biosynthetic pathways for compounds 1—3 are proposed. All compounds exhibited antiadipogenic effects in 3T3‐L1 adipocytes, and the most potent compound 4 showed an EC50 value of 3.92 μmol/L with low cytotoxicity (IC50 > 89.54 μmol/L).

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Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis

Cited by 4 publications

References 55 publications

ATP-Citrate Lyase (ACLY): An Extensive Investigation from Molecular Insight to Therapeutic implications

ATP-Citrate Lyase (ACLY): An Extensive Investigation from Molecular Insight to Therapeutic implications

Anti-Inflammatory Salicin Derivatives from the Barks of Salix tetrasperma

Skeleton Rearranged and Oxygenated ent‐Rosane Diterpenoids with Antiadipogenic Activity from Euphorbia milii

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