2021
DOI: 10.1101/2021.05.18.444627
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Highly basic clusters in the HSV-1 nuclear egress complex drive membrane budding by inducing lipid ordering

Abstract: During replication of herpesviruses, capsids escape from the nucleus into the cytoplasm by budding at the inner nuclear membrane. This unusual process is mediated by the viral nuclear egress complex (NEC) that deforms the membrane around the capsid by oligomerizing into a hexagonal, membrane-bound scaffold. Here, we found that highly basic membrane-proximal regions (MPRs) of the NEC alter lipid order by inserting into the lipid headgroups and also promote negative Gaussian curvature. We also find that the elec… Show more

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