Highly catalysis amplification of MOF<sub>Nd</sub>-loaded nanogold combined with specific aptamer SERS/RRS assay of trace glyphosate

Li, Jingjing; Shi, Jinling; Liang, Aihui; Jiang, Zhiliang

doi:10.1039/d2an00549b

Cited by 13 publications

(7 citation statements)

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“…On top of that, aptamers show higher stability than the antibodies and their handling is relatively easy. There are a number of recent publications in the scientific literature on the use of aptamers to detect pesticides , and herbicides . The area of aptasensors and SERS-based aptasensors for the detection of toxic agrochemicals is relatively new compared to the development of these biosensor platforms for other types of target chemical and biological substances …”

Section: Introductionmentioning

confidence: 99%

“…There are a number of recent publications in the scientific literature on the use of aptamers to detect pesticides 39,40 and herbicides. 41 The area of aptasensors and SERS-based aptasensors for the detection of toxic agrochemicals is relatively new compared to the development of these biosensor platforms for other types of target chemical and biological substances. 42 In this work, we report the development of a SERS-based aptasensor for selective detection of PQ in water.…”

Section: Introductionmentioning

confidence: 99%

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Au Nanoparticle-Based Surface-Enhanced Raman Spectroscopy Aptasensors for Paraquat Herbicide Detection

Kamkrua

Ngernsutivorakul

Limwichean

et al. 2023

ACS Appl. Nano Mater.

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Herein, we developed a surface-enhanced Raman spectroscopy (SERS)-based aptasensor platform by modifying gold (Au) nanoparticle SERS substrates with a thiol-containing aptamer for sensitive and selective detection of paraquat (PQ), a commonly used herbicide for weed and grass control. The Au nanoparticle SERS substrate used in this study is a commercial SERS substrate (ONSPEC-Lite, https://www.nectec.or.th/en/innovation/productinnovation/onspec-series.html) developed by our group at NECTEC, Thailand. The average size of the nanoparticle is 59 ± 17 nm. A thiol-modified aptamer PQ77-SH was immobilized on the Au nanoparticle surface and used as a bioreceptor for binding the PQ molecules selectively on the SERS substrate. PQ detection in water medium using the SERS-based aptasensor substrates was carried out by observing the Raman peak intensities of PQ at different concentrations and compared with SERS substrates without aptamer modifications. Modification of the SERS substrates with aptamers improves the sensitivity and enables selective detection of PQ with a limit of detection estimated to be 0.10 ± 0.03 μM. The developed SERS-based aptasensor platform was evaluated using natural water samples collected from a nearby pond and demonstrated good stability against interferences from other similar herbicides and insecticides present along with PQ in water. The findings of this study indicate that the SERS-based aptasensor not only increases the sensitivity of SERS substrates but also, and this is crucial, makes them selective toward PQ detection, assisting in resolving the problem of low selectivity from conventional SERS substrates.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Au Nanoparticle-Based Surface-Enhanced Raman Spectroscopy Aptasensors for Paraquat Herbicide Detection

Kamkrua

Ngernsutivorakul

Limwichean

et al. 2023

ACS Appl. Nano Mater.

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“…Thus, the analysis of these modes was shown to be interesting. Based on the nanocatalytic amplification and specific Apt, a surface-enhanced Raman scattering/resonance Rayleigh scattering (RRS) dimode assay was proposed for the detection of trace glyphosate ( 16 ). The fluorescence, coupled with the Abs method, to establish a dimode Apt method has the advantages of selectivity, sensitivity, and low cost.…”

Section: Introductionmentioning

confidence: 99%

MXene catalytic amplification-fluorescence/absorption dimode aptamer sensor for the detection of trace Pb2+ in milk

Zhi

Wei²,

Zhang³

et al. 2022

Front. Nutr.

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Lead ion (Pb2+) is a toxic heavy metal, which is very harmful to organisms. Therefore, the establishment of a rapid, simple, and sensitive method is of great significance to food safety and human health. It was found that MXeneTi3C2 nanosheet (NS) has a strong catalytic effect on the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) via H2O2 to form the oxidized product (TMBOX); it has a strong fluorescence peak at 415 nm and an absorption (Abs) peak at 295 nm. The aptamer of Pb2+ (Aptpb) can be adsorbed on the surface of an NS to form MXene-Apt conjugates, which reduces its catalytic active sites and inhibits its catalytic activity. When the target Pb2+ is added, it specifically binds with Aptpb to release MXene NSs to enhance the dimode signals. Therefore, a new MXene catalytic fluorescence/absorption dimode aptamer biosenering platform was fabricated for the determination of trace Pb2+ in milk and water samples, with the fluorescence assay linear range (LR) of 5.0 × 10−2-2.0 nmol/L.

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“…In this regard, these issues can be solved by functionalization on the surface of noble metal nanomaterials or incorporating additional functional layers such as metal–organic frameworks (MOFs), which are ordered porous materials composed of metal ions and organic ligands connected by coordination bonds . These materials are highly structural and chemically tunable, which have been widely used in many popular research fields such as gas storage, catalysis, and drug delivery. − Typically, when used as SERS substrates, the porous structure of MOFs facilitates the loading of Raman reporter molecules, while their flexible surface chemistry allows for further chemical modifications . Besides, the molecular structure of MOFs may provide an additional CM enhancement effect.…”

mentioning

confidence: 99%

“…30−32 Typically, when used as SERS substrates, the porous structure of MOFs facilitates the loading of Raman reporter molecules, while their flexible surface chemistry allows for further chemical modifications. 33 Besides, the molecular structure of MOFs may provide an additional CM enhancement effect. Therefore, the composite nanomaterials combining plasmonic nanoparticles and MOFs are expected to be adopted for the construction of SERS substrate materials with high sensitivity, stability, reproducibility, and complex detection capacities through rational design.…”

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confidence: 99%

Ultrasensitive Multiplex Imaging of Cell Surface Proteins via Core-Shell Surface-Enhanced Raman Scattering Nanoprobes

et al. 2023

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Cell surface proteins, as important components of biological membranes, cover a wide range of important markers of diseases and even cancers. In this regard, precise detection of their expression levels is of crucial importance for both cancer diagnosis and the development of responsive therapeutic strategies. Herein, a size-controlled core-shell Au@ Copper(II) benzene-1,3,5-tricarboxylate (Au@Cu-BTC) nanomaterial was synthesized for specific and simultaneous imaging of multiple protein expression levels on cell membranes. The porous shell of Cu-BTC constructed on Au nanoparticles enabled effective loading of Raman reporter molecules, followed by further modification of the targeting moieties, which equipped the nanoprobe with good specificity and stability. Additionally, given the flexibility of the types of Raman reporter molecules available for loading, the nanoprobes were also demonstrated with good multichannel imaging capabilities. Ultimately, the present strategy of electromagnetic and chemical dual Raman scattering enhancement was successfully applied for the simultaneous detection of varied proteins on cell surfaces with high sensitivity and accuracy. The proposed nanomaterial holds promising applications in biosensing and therapeutic fields, which could not only provide a general strategy for the synthesis of metal−organic framework-based core-shell surface-enhanced Raman scattering nanoprobes but also enable further utilization in multitarget and multichannel cell imaging.

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Highly catalysis amplification of MOF_Nd-loaded nanogold combined with specific aptamer SERS/RRS assay of trace glyphosate

Abstract: The neodymium metal-organic framework (MOFNd) was prepared by using 1H-pyrazole-3,5-dicarboxylic acid (H3pdc) and 2-pyrazinecarboxylic acid as ligand. Addition of HAuCl4 as precursor and NaBH4 as reducing agent, a new MOFNd-loaded...

Cited by 13 publications

References 40 publications

Au Nanoparticle-Based Surface-Enhanced Raman Spectroscopy Aptasensors for Paraquat Herbicide Detection

Au Nanoparticle-Based Surface-Enhanced Raman Spectroscopy Aptasensors for Paraquat Herbicide Detection

MXene catalytic amplification-fluorescence/absorption dimode aptamer sensor for the detection of trace Pb2+ in milk

Ultrasensitive Multiplex Imaging of Cell Surface Proteins via Core-Shell Surface-Enhanced Raman Scattering Nanoprobes

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Highly catalysis amplification of MOFNd-loaded nanogold combined with specific aptamer SERS/RRS assay of trace glyphosate

Abstract: The neodymium metal-organic framework (MOFNd) was prepared by using 1H-pyrazole-3,5-dicarboxylic acid (H3pdc) and 2-pyrazinecarboxylic acid as ligand. Addition of HAuCl4 as precursor and NaBH4 as reducing agent, a new MOFNd-loaded...

Cited by 13 publications

References 40 publications

Au Nanoparticle-Based Surface-Enhanced Raman Spectroscopy Aptasensors for Paraquat Herbicide Detection

Au Nanoparticle-Based Surface-Enhanced Raman Spectroscopy Aptasensors for Paraquat Herbicide Detection

MXene catalytic amplification-fluorescence/absorption dimode aptamer sensor for the detection of trace Pb2+ in milk

Ultrasensitive Multiplex Imaging of Cell Surface Proteins via Core-Shell Surface-Enhanced Raman Scattering Nanoprobes

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Highly catalysis amplification of MOF_Nd-loaded nanogold combined with specific aptamer SERS/RRS assay of trace glyphosate