Highly diversified Zika viruses imported to China, 2016

Zhang, Yanjun; Chen, Wenxian; Wong, Gary; Bi, Yuhai; Yan, Juying; Sun, Yi; Chen, Enfu; Yan, Huan; Fang, Zhiguo; Mao, Haiyan; Xia, Shichang; Gao, George F.; Shi, Weifeng; Chen, Zhiping

doi:10.1007/s13238-016-0274-5

Cited by 51 publications

(47 citation statements)

References 16 publications

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“…Seven sequences from China associated with ZIKV cases were used in the analysis. The present study using NS5 also observed results similar to Zhang et al [] using genome sequence. This study included two additional sequences AMR39830 (KU955589) and AMR39831 (KU955590) deposited in GenBank on 23rd March 2016 hence was not included in the analysis by Zhang et al [].…”

Section: Resultssupporting

confidence: 91%

“…The sequences in the Latin American genotype which are of clinical origin include AMQ34004, AMQ34003, AMM39804, AMZ03557, AMC33116, ANB66184, ANB66182, ANB66183. Although Zhang et al [] did similar work of clustering strains from Colombia, Mexico, and Martinique, they failed to observe the amino acid mutation T581A, since they did not use the protein sequence of NS5 in the analysis. Their group also did not include sequences from Panama isolates which also bears T581A mutation (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Phylogenetic analysis of the NS5 gene of Zika virus

Adiga

2016

Journal of Medical Virology

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ZIKV infection has become a global threat spreading across 31 countries in Central America, South America, and the Caribbean. However, little information is available about the molecular epidemiology of ZIKV. Shared mutation of a threonine residue to alanine at the same position in the C terminal of NS5 sequences was observed in sequences from Colombia, Mexico, Panama, and Martinique. The sequences in the phylogenetic tree fell within the same cluster. Based on shared mutation the presence of a Latin American genotype was proposed. Comparison of African and Asian lineages yielded R29N, N273S, H383Q, and P391S mutation. The study highlights that mutation of amino acids at NS5 may contribute to neutropism of ZIKV. J. Med. Virol. 88:1821-1826, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Phylogenetic analysis of the NS5 gene of Zika virus

Adiga

2016

Journal of Medical Virology

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“…Since then, 13 cases caused by imported Zika virus have been reported from several provinces ( 21 ); no evidence of autochthonous transmission has been found. In China, Ae.…”

mentioning

confidence: 99%

Competence of Aedes aegypti, Ae. albopictus, and Culex quinquefasciatus Mosquitoes as Zika Virus Vectors, China

Liu¹,

Zhou²,

Lai³

et al. 2017

Emerg. Infect. Dis.

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In China, the prevention and control of Zika virus disease has been a public health threat since the first imported case was reported in February 2016. To determine the vector competence of potential vector mosquito species, we experimentally infected Aedes aegypti, Ae. albopictus, and Culex quinquefasciatus mosquitoes and determined infection rates, dissemination rates, and transmission rates. We found the highest vector competence for the imported Zika virus in Ae. aegypti mosquitoes, some susceptibility of Ae. albopictus mosquitoes, but no transmission ability for Cx. quinquefasciatus mosquitoes. Considering that, in China, Ae. albopictus mosquitoes are widely distributed but Ae. aegypti mosquito distribution is limited, Ae. albopictus mosquitoes are a potential primary vector for Zika virus and should be targeted in vector control strategies.

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“…For adults, ZIKV infection is associated with Guillain-Barré syndrome (6). The current epidemic of ZIKV in the Americas (since 2015) has explosively spilled over to 84 countries worldwide (1), including China (7,8). In 2016, the World Health Organization declared the microcephaly, neurological disorders, and their association with ZIKV infection to be a global public health emergency (9).…”

mentioning

confidence: 99%