Highly Efficient Antimicrobial and Antifouling Surface Coatings with Triclosan-Loaded Nanogels

Osteosynthesis systems are used to fixate bone segments in maxillofacial surgery. Titanium osteosynthesis systems are currently the gold standard. However, the disadvantages result in symptomatic removal in up to 40% of cases. Biodegradable osteosynthesis systems, composed of degradable polymers, could reduce the need for removal of osteosynthesis systems while avoiding the aforementioned disadvantages of titanium osteosyntheses. However, disadvantages of biodegradable systems include decreased mechanical properties and possible foreign body reactions. In this review, the literature that focused on the in vitro and in vivo performances of biodegradable and titanium osteosyntheses is discussed. The focus was on factors underlying the favorable clinical outcome of osteosyntheses, including the degradation characteristics of biodegradable osteosyntheses and the host response they elicit. Furthermore, recommendations for clinical usage and future research are given. Based on the available (clinical) evidence, biodegradable copolymeric osteosyntheses are a viable alternative to titanium osteosyntheses when applied to treat maxillofacial trauma, with similar efficacy and significantly lower symptomatic osteosynthesis removal. For orthognathic surgery, biodegradable copolymeric osteosyntheses are a valid alternative to titanium osteosyntheses, but a longer operation time is needed. An osteosynthesis system composed of an amorphous copolymer, preferably using ultrasound welding with well-contoured shapes and sufficient mechanical properties, has the greatest potential as a biocompatible biodegradable copolymeric osteosynthesis system. Future research should focus on surface modifications (e.g., nanogel coatings) and novel biodegradable materials (e.g., magnesium alloys and silk) to address the disadvantages of current osteosynthesis systems.

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“…N-nGel, nonquaternized nanogel; Q-nGel, quaternized nanogel; TCS, triclosan; CFU, colony-forming units. Reprinted with permission from [ 122 ].…”

Section: Figurementioning

confidence: 99%

Titanium or Biodegradable Osteosynthesis in Maxillofacial Surgery? In Vitro and In Vivo Performances

Gareb¹,

Bakelen²,

Vissink³

et al. 2022

Polymers

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“…In our very recent study, we prepared antibacterial surfaces with poly (N-isopropylacrylamide- co -N-[3 (dimethylamino)propyl]methacrylamide) (P(NIPAM- co -DMAPMA)-based nanogels [ 297 ]. Through the tertiary amine in the DMAPMA comonomer, nanogels are quaternized which introduced the antibacterial activity due to the bacterial membrane binding and the intercalating ability of the aliphatic QAC.…”

Section: Antimicrobial Nanogel Surface Coatings For Biomedical Applicationsmentioning

confidence: 99%

Nanogels: A novel approach in antimicrobial delivery systems and antimicrobial coatings

Keskin

Forson

et al. 2021

Bioactive Materials

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The implementation of nanotechnology to develop efficient antimicrobial systems has a significant impact on the prospects of the biomedical field. Nanogels are soft polymeric particles with an internally cross-linked structure, which behave as hydrogels and can be reversibly hydrated/dehydrated (swollen/shrunken) by the dispersing solvent and external stimuli. Their excellent properties, such as biocompatibility, colloidal stability, high water content, desirable mechanical properties, tunable chemical functionalities, and interior gel-like network for the incorporation of biomolecules, make them fascinating in the field of biological/biomedical applications. In this review, various approaches will be discussed and compared to the newly developed nanogel technology in terms of efficiency and applicability for determining their potential role in combating infections in the biomedical area including implant-associated infections.

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“…The quaternized nano-gels caused intraparticle hydrophobic domains. Triclosan incorporated nano-gels killed 99.99% of pathogens on the surface of clinical coatings [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Recent breakthroughs of antibacterial and antiviral protective polymeric materials during COVID-19 pandemic and after pandemic: Coating, packaging, and textile applications

Mallakpour

Azadi

Hussain

2021

Current Opinion in Colloid & Interface Science

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The global epidemic owing to COVID-19 has generated awareness to ensuring best practices for avoiding the microorganisms spread. Indeed, due to the increase in infections caused by bacteria and viruses such as SARS-CoV-2, the global demand for antimicrobial materials is growing. New technologies by employing polymeric systems are of great interest. Virus transmission by contaminated surfaces leads to the spread of infectious diseases, so, antimicrobial coatings are significant in this regard. Moreover, antimicrobial food packaging is beneficial to prevent the spread of microorganisms during food processing and transportation. Further, antimicrobial textiles show an effective role. We aim to provide a review of prepared antimicrobial polymeric materials for use in coating, food packaging, and textile during the COVID-19 pandemic and post-pandemic.

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Highly Efficient Antimicrobial and Antifouling Surface Coatings with Triclosan-Loaded Nanogels

Cited by 45 publications

References 53 publications

Titanium or Biodegradable Osteosynthesis in Maxillofacial Surgery? In Vitro and In Vivo Performances

Titanium or Biodegradable Osteosynthesis in Maxillofacial Surgery? In Vitro and In Vivo Performances

Nanogels: A novel approach in antimicrobial delivery systems and antimicrobial coatings

Recent breakthroughs of antibacterial and antiviral protective polymeric materials during COVID-19 pandemic and after pandemic: Coating, packaging, and textile applications

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