Highly efficient immobilization of endo-1,3-β-d-glucanases (laminarinases) from marine mollusks in novel hybrid polysaccharide-silica nanocomposites with regulated composition

Shchipunov, Yu. A.; Burtseva, Yu. V.; Karpenko, Tat'yana Yu.; Шевченко, Н. М.; Zvyagintseva, T. N.

doi:10.1016/j.molcatb.2006.02.002

Cited by 55 publications

(23 citation statements)

References 28 publications

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“…Ethylene glycol generated after its hydrolysis is compatible with biopolymers. It was found in our experiments where hybrid polysaccharide-silica nanocomposites were fabricated [20][21][22]38] and highly labile enzymes were entrapped into the sol-gel derived silica matrix [40,41]. The absence of perceptible effect of THEOS on the protein conformation let us reveal the effect of pH change on the morphology of protein-silica hybrids caused by the pH-tuned protein denaturation (Fig.…”

Section: Resultsmentioning

confidence: 64%

Regulation of silica morphology by proteins serving as a template for mineralization

Shchipunov

Shipunova

2008

Colloids and Surfaces B: Biointerfaces

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Section: Resultsmentioning

confidence: 64%

Regulation of silica morphology by proteins serving as a template for mineralization

Shchipunov

Shipunova

2008

Colloids and Surfaces B: Biointerfaces

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“…High temperature (≥100°C) in calcination or spray drying can alter the textural properties of MSN and damage biomolecules. 60,62 Spray drying after sol-gel process can drastically change the properties of sol-gels, which can even result in non-porous structure. 24 At high temperatures, the shrinkage of mesopores is significant, which results in inability to control morphology of MSN, 25,75 and the template cannot be recovered or re-used, which results in economic disadvantages.…”

Section: Currently Available Drug Delivery Systemsmentioning

confidence: 99%

Silica-based mesoporous nanoparticles for controlled drug delivery

et al. 2013

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Drug molecules with lack of specificity and solubility lead patients to take high doses of the drug to achieve sufficient therapeutic effects. This is a leading cause of adverse drug reactions, particularly for drugs with narrow therapeutic window or cytotoxic chemotherapeutics. To address these problems, there are various functional biocompatible drug carriers available in the market, which can deliver therapeutic agents to the target site in a controlled manner. Among the carriers developed thus far, mesoporous materials emerged as a promising candidate that can deliver a variety of drug molecules in a controllable and sustainable manner. In particular, mesoporous silica nanoparticles are widely used as a delivery reagent because silica possesses favourable chemical properties, thermal stability and biocompatibility. Currently, sol-gel-derived mesoporous silica nanoparticles in soft conditions are of main interest due to simplicity in production and modification and the capacity to maintain function of bioactive agents. The unique mesoporous structure of silica facilitates effective loading of drugs and their subsequent controlled release. The properties of mesopores, including pore size and porosity as well as the surface properties, can be altered depending on additives used to fabricate mesoporous silica nanoparticles. Active surface enables functionalisation to modify surface properties and link therapeutic molecules. The tuneable mesopore structure and modifiable surface of mesoporous silica nanoparticle allow incorporation of various classes of drug molecules and controlled delivery to the target sites. This review aims to present the state of knowledge of currently available drug delivery system and identify properties of an ideal drug carrier for specific application, focusing on mesoporous silica nanoparticles.

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“…[226] In-cell concentration of soluble forms of silica in diatoms is from 19 to 340 mM, which exceeds significantly equilibrium concentration in solution (2-3 mM). Silica is bound with organic substances, most probably, in form of spherical particles in special silicon transport vesicles (STV), their size is about 30-40 nm [232,233,229]. However, it is not excluded that silicic acid presents in cytoplasm in form of soluble complexes of oligo-silicates with polymers, though it is unknown how high can be concentrations of silica in cytoplasm to do no harm to cells.…”

Section: Biomineralization and Bioconcentrationmentioning

confidence: 99%

“…Their usage in development of nanostructured hybrid materials has recently increased, because natural polysaccharides can be promising and available substitutes for non-degrading polymers due to their biodegradation, biocompatibility and availability. Hybrid nanocomposites based on polysaccharides are used for immobilizing of ferments without loss of their activity and increase in stability [233,299,300].…”

Section: Nanocomposites Based On Polysaccharidesmentioning

confidence: 99%

Bionanocomposites Assembled by “From Bottom to Top” Method

Pomogailo

Джардималиева

2014

Nanostructured Materials Preparation via Condensation Ways

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Particles, which take part in different biological processes, have a special place in nanometer composites. Rich and variable biochemistry of proteins displays key importance of a nanometer phenomenon for a working mechanism of living organisms [1,2], and this provides a wide range of possibilities for development of new types of hybrid nanomaterials with constructible structures, functions and shapes [3][4][5].Integration of nanoparticles and biomolecules, each having unique properties, on the one hand, and being in the same nanometer scale (enzymes, antigens, and antibodies of typical sizes 2-20 nm like nanoparticles), on the other hand, as of two structurally compatible classes of materials, gives resultant new hybrid nanomaterials with synergetic properties and functions (Fig. 7.1).Interaction of nanoparticles with biopolymers (proteins, nucleic acids, polysaccharides) plays very important role in enzyme catalysis, biosorption, biohydrometallurgy, geobiotechnology, etc.). There is a great interest to nanomaterials, which can be used in biomedical and pharmaceutical applications due to their biocompatibility and biodegradation. At the same time bionanocomposites should meet some demands to plasticity of a matrix, they should have improved barrier, antimicrobial properties, ability to controlled release of bioactive substances such as antimicrobial agents, antioxidants, drugs, calcium compounds in biologically available form and their mixtures, etc. Biopolymers, such as natural and synthetic proteins, obtained by chemical methods or by genetic modification of microorganisms or plants, nucleic acids (including synthetic ones), biodegraded complex polyethers, such as polylactic acid, and its derivatives, oligo-hydroxyalkanoate, most often, polyhydroxybutyrate, their copolymers, biomedical materials, such as hydroxyapatites, are used. There is an interesting group of materials for this purpose including synthetic and natural (vegetable and animal) polysaccharides, such as cellulose and its derivatives, alginates, dextranes, acacia gum, chitosan, and any of its natural and synthetic derivatives, especially chitosan acetate, and proteins obtained from raw animal materials, as well as proteins from maize (especially zein) or soya, gluten derivatives, gelatin, casein, etc. Relatively widely used in

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Highly efficient immobilization of endo-1,3-β-d-glucanases (laminarinases) from marine mollusks in novel hybrid polysaccharide-silica nanocomposites with regulated composition

Cited by 55 publications

References 28 publications

Regulation of silica morphology by proteins serving as a template for mineralization

Regulation of silica morphology by proteins serving as a template for mineralization

Silica-based mesoporous nanoparticles for controlled drug delivery

Bionanocomposites Assembled by “From Bottom to Top” Method

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