Highly efficient Mukaiyama-Mannich addition of α-diazo silyl enolate with nitrones catalyzed by MgI2 etherate

C−H Activation and Cross‐Coupling of Acyclic Aldonitrone

“…Nitrones have been used as the key intermediates in the synthesis of a great variety of natural and biologically active compounds such as aminoacids and their unnatural analogues, alkaloids or pharmaceuticals, including β‐lactams [4] or even DNA derivatives [5] . This is a consequence of diverse reactivity of nitrones that includes such carbon‐carbon bond forming reactions as 1,3‐dipolar cycloaddition, [6] addition of nucleophiles to the double carbon‐nitrogen bond, [7] Kinugasa reaction [4a] or reductive coupling with carbonyl compounds [8] . Unsurprisingly, in recent years there has been a great interest in exploiting nitrones in transition metal‐catalyzed reactions, either as simple directing groups for C−H activation occurring in the neighboring aromatic ring, [9] or more complicated processes in which, following a ring C−H activation step, the nitrone moiety participates in annulation [10] or intramolecular dipolar cycloaddition [11]…”