Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages

Yang, Fengbo; Jia, Xiaoli; Hua, Chao; Zhou, Feifan; Hua, Jianing; Ji, Yuting; Zhao, Peng; Yuan, Quan; Xing, Malcolm; Lyu, Guozhong

doi:10.1016/j.bioactmat.2024.02.006

Bioactive Materials

2024

DOI: 10.1016/j.bioactmat.2024.02.006

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Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages

Fengbo Yang,

Xiaoli Jia,

Chao Hua

et al.

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2024

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Cited by 2 publications

References 54 publications

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Ultra‐Hydrophobic Gauze Driving Super‐Haemostasis

Chen,

Yang,

Liu

et al. 2024

Adv Healthcare Materials

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Controlling bleeding by applying pressing cotton gauze is the most facile treatment in prehospital emergencies. However, the wettable nature of cotton fibers leads to unnecessary blood loss due to excessive blood absorption, inseparable adhesion‐induced pain, and pliable to infection. Here, we develop a kind of ultra‐hydrophobic haemostatic anti‐adhesive gauze whose surface is loaded with polydimethylsiloxane (PDMS) and hydrophobic‐modified cellulose nanocrystals (CNCs), achieving a water contact angle of about 160°. We demonstrate that the mechanism by which hydrophobic CNCs promote blood clotting is associated with their ability to activate coagulation factors, contributing to fibrin formation, and promoting platelet activation. The blood‐restricting effect results from the low surface energy layer formed by PDMS and then the alkyl chains of hydrophobic CNCs were combined. The produced ultra‐hydrophobic gauze resists blood flow and diffusion, decreases blood loss, is effortlessly peel‐able, and minimizes pathogen adhesion. Compared to the commercial cotton gauze, our gauze achieved effective haemostasis and antiadhesion by reducing blood loss by more than 90%, shortening haemostasis time by more than 75%, lowering peeling force by more than 90% and minifying bacterium attachment by more than 95%. Our work presents promising applications in terms of prehospital first aid.This article is protected by copyright. All rights reserved

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Ultra‐Hydrophobic Gauze Driving Super‐Haemostasis

Chen,

Yang,

Liu

et al. 2024

Adv Healthcare Materials

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Blue Laser Triggered Hemostatic Peptide Hydrogel for Gastrointestinal Bleeding Treatment

Luo,

Luan

et al. 2024

Advanced Materials

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In an emergency, nonvariceal upper gastrointestinal bleeding (NVUGIB), endoscopic hemostasis is considered the gold standard intervention. However, current endoscopic hemostasis is very challenging to manage bleeding in large‐diameter or deep lesions highly prone to rebleeding risk. Herein, a novel hemostatic peptide hydrogel (HPH) is reported, consisting of a self‐assembly peptide sequence CFLIVIGSIIVPGDGVPGDG (PFV) and gelatin methacryloyl (GelMA), which can be triggered by blue laser endoscopy (BLE) for nonvariceal upper gastrointestinal bleeding treatment without recurring bleeding concerns. Upon contact with GelMA solution, PFV immediately fibrillates into β‐sheet nanofiber and solvent‐induced self‐assembly to form HPH gel. HPH nanofiber networks induced ultrafast coagulation by enveloping blood cells and activating platelets and coagulation factors even to the blood with coagulopathy. Besides its remarkable hemostatic performance in artery and liver injury models, HPH achieves instant bleeding management in porcine NVUGIB models within 60 s by preventing the rebleeding risk. This work demonstrates an extraordinary hemostatic agent for NVUGIB intervention by BLE for the first time, broadening potential application scenarios, including patients with coagulopathy and promising clinical prospects.

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Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages

Cited by 2 publications

References 54 publications

Ultra‐Hydrophobic Gauze Driving Super‐Haemostasis

Ultra‐Hydrophobic Gauze Driving Super‐Haemostasis

Blue Laser Triggered Hemostatic Peptide Hydrogel for Gastrointestinal Bleeding Treatment

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