Highly efficient SERS substrate for direct detection of explosive TNT using popcorn-shaped gold nanoparticle-functionalized SWCNT hybrid

Demeritte, Teresa; Kanchanapally, Rajashekhar; Fan, Zhen; Singh, Anant Kumar; Senapati, Dulal; Dubey, Madan; Zakar, Eugene; Ray, Paresh Chandra

doi:10.1039/c2an35984g

Cited by 71 publications

(61 citation statements)

References 37 publications

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“…41 The SERS enhancement factor is about 2 orders of magnitude higher than only nanoparticle. 41 Due to the huge SERS enhancement via high density “hot site” formation, we have used 1D hybrid CNT substrate based SERS for explosive detection.…”

Section: Developing Hybrid Cnt Based 1d Sers Substrate For Fingerprinmentioning

confidence: 97%

“…37 Due to the resonance phenomena between incident light and SERS substrate extinction, 2–3 orders of magnitude SERS enhancement are expected. 37,39,41,42 …”

Section: Developing Hybrid Cnt Based 1d Sers Substrate For Fingerprinmentioning

confidence: 99%

“…(H) Raman intensity from TNT on popcorn shape nanoparticle and nanoparticle attached SWCNT. (I) TNT Raman intensity enhancement on nanoparticle and nanoparticle attached SWCNT (Reproduced with permission from ref (41). Copyright 2012 Royal Society of Chemistry).…”

Section: Developing Hybrid Cnt Based 1d Sers Substrate For Fingerprinmentioning

confidence: 99%

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Nanoarchitecture Based SERS for Biomolecular Fingerprinting and Label-Free Disease Markers Diagnosis

et al. 2016

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ConspectusSurface-enhanced Raman spectroscopy (SERS) fingerprinting is highly promising for identifying disease markers from complex mixtures of clinical sample, which has the capability to take medical diagnoses to the next level. Although vibrational frequency in Raman spectra is unique for each biomolecule, which can be used as fingerprint identification, it has not been considered to be used routinely for biosensing due to the fact that the Raman signal is very weak. Contemporary SERS has been demonstrated to be an excellent analytical tool for practical label-free sensing applications due its ability to enhance Raman signals by factors of up to 108–1014 orders of magnitude. Although SERS was discovered more than 40 years ago, its applications are still rare outside the spectroscopy community and it is mainly due to the fact that how to control, manipulate and amplify light on the “hot spots” near the metal surface is in the infancy stage.In this Account, we describe our contribution to develop nanoachitecture based highly reproducible and ultrasensitive detection capability SERS platform via low-cost synthetic routes. Using one-dimensional (1D) carbon nanotube (CNT), two-dimensional (2D) graphene oxide (GO), and zero-dimensional (0D) plasmonic nanoparticle, 0D to 3D SERS substrates have been designed, which represent highly powerful platform for biological diagnosis. We discuss the major design criteria we have used to develop robust SERS substrate to possess high density “hot spots” with very good reproducibility. SERS enhancement factor for 3D SERS substrate is about 5 orders of magnitude higher than only plasmonic nanoparticle and more than 9 orders of magnitude higher than 2D GO. Theoretical finite-difference time-domain (FDTD) stimulation data show that the electric field enhancement |E|2 can be more than 2 orders of magnitude in “hot spots”, which suggests that SERS enhancement factors can be greater than 104 due to the formation of high density “hot spots” in 3D substrate. Next, we discuss the utilization of nanoachitecture based SERS substrate for ultrasensitive and selective diagnosis of infectious disease organisms such as drug resistance bacteria and mosquito-borne flavi-viruses that cause significant health problems worldwide. SERS based “whole-organism fingerprints” has been used to identify infectious disease organisms even when they are so closely related that they are difficult to distinguish. The detection capability can be as low as 10 CFU/mL for methicillin-resistant Staphylococcus aureus (MRSA) and 10 PFU/mL for Dengue virus (DENV) and West Nile virus (WNV). After that, we introduce exciting research findings by our group on the applications of nanoachitecture based SERS substrate for the capture and fingerprint detection of rotavirus from water and Alzheimer’s disease biomarkers from whole blood sample. The SERS detection limit for β-amyloid (Aβ proteins) and tau protein using 3D SERS platform is several orders of magnitude higher than the currently used technology in clinics. Finally, w...

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Section: Developing Hybrid Cnt Based 1d Sers Substrate For Fingerprinmentioning

confidence: 97%

“…37 Due to the resonance phenomena between incident light and SERS substrate extinction, 2–3 orders of magnitude SERS enhancement are expected. 37,39,41,42 …”

Section: Developing Hybrid Cnt Based 1d Sers Substrate For Fingerprinmentioning

confidence: 99%

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Nanoarchitecture Based SERS for Biomolecular Fingerprinting and Label-Free Disease Markers Diagnosis

et al. 2016

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“…This enhancement allows the detection/identification of molecules even at a single molecule level [20,21]. Demeritte et al reported the detection of TNT (100 fM) molecules using popcorn-shaped Au NPs functionalized with single walled carbon nanotubes [22]. Chen et al detected ammonium nitrate (AN) and RDX with EF of ∼7.0 × 10 4 using a monolayer of ordered Au NPs on Si substrates [23].…”

Section: Introductionmentioning

confidence: 99%

Femtosecond Laser Fabricated Ag@Au and Cu@Au Alloy Nanoparticles for Surface Enhanced Raman Spectroscopy Based Trace Explosives Detection

2018

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Herein we present results from our detailed studies on the fabrication of Ag@Au and Cu@Au alloy nanoparticles (NPs) using the femtosecond laser ablation in liquid technique. The NPs were obtained by ablating the pure Ag, Cu targets (bulk) in HAuCl 4 (5 mM) solution. The absorption properties of the obtained NPs colloids were characterized using UV-Visible absorption spectrometer and their size, shape, and crystallinity were investigated using the XRD, FESEM and TEM techniques. The fabricated NPs were utilized for sensing of explosive molecules such as 2,4,6-trinitrophenol (PA), 2,4-dinitrotoluene (DNT) and a common dye methylene blue (MB) using the surface enhanced Raman spectroscopy (SERS) technique. The detection limit in terms of weight was as low as few nano-grams in the case of nitroaromatic explosive compounds (PA, DNT) and few picograms in the case of a common dye molecule (MB). Typical enhancement factors achieved were estimated to be ∼10 4 , ∼10 5 , and ∼10 7 , respectively, for PA, DNT, and MB. The significance of the present work lies in exploring the performance of the prepared NPs being used as SERS substrates for explosives detection using a portable Raman instrument. Such capability enables one to carry the spectrometer to the point of interest in the field and evaluate any hazardous samples within a short period of time.

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“…In the last decade, the technique of SERS has been intensively studied due to its great potentials for label-free and multiplex detection of biomolecules [1][2][3], pollutants [4,5], and chemical warfare agents [6][7][8]. When light interacts with noble metal NPs with very narrow junctions, the conduction-band electrons in the NP can collectively oscillate and generate localized surface plasmon.…”

Section: Introductionmentioning

confidence: 99%

Electric-Field Enhanced Molecule Detection in Suspension on Assembled Plasmonic Arrays by Raman Spectroscopy

Liu

Fan

2014

Journal of Nanotechnology in Engineering and Medicine

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One of the greatest challenges in surface enhanced Raman scattering (SERS) sensing is to detect biochemicals directly from suspension with ultrasensitivity. In this work, we employed strategically designed longitudinal nanocapsule structures with uniformly surface distributed Ag nanoparticles (Ag NPs) to dually focus and enhance SERS sensitivity of biochemicals in suspension assisted with electric fields. By tuning the reaction conditions, Ag NPs were synthesized and uniformly grown with optimized sizes and junctions on the surface of nanocapsules for well reproducible detection. The Ag NPs can further concentrate molecules from suspension due to induced electrokinetic effects in electric fields. As a result, the signals of Nile blue molecules can be enhanced by 34.463.1% at optimal alternating current (AC) frequencies and voltages compared to that without electric fields. This work demonstrates the dual roles of a new type of plasmonic NPs for molecule concentration and detection, which could inspire new Raman sensing devices for applications in microfluidics.

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Highly efficient SERS substrate for direct detection of explosive TNT using popcorn-shaped gold nanoparticle-functionalized SWCNT hybrid

Cited by 71 publications

References 37 publications

Nanoarchitecture Based SERS for Biomolecular Fingerprinting and Label-Free Disease Markers Diagnosis

Nanoarchitecture Based SERS for Biomolecular Fingerprinting and Label-Free Disease Markers Diagnosis

Femtosecond Laser Fabricated Ag@Au and Cu@Au Alloy Nanoparticles for Surface Enhanced Raman Spectroscopy Based Trace Explosives Detection

Electric-Field Enhanced Molecule Detection in Suspension on Assembled Plasmonic Arrays by Raman Spectroscopy

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