Highly efficient solid-phase derivatization of sugar phosphates with titanium-immobilized hydrophilic polydopamine-coated silica

Qian, Qing; Wang, Bohong; Chang, Mengmeng; Zhou, Zhonggao; Shi, Xianzhe; Xu, Guowang

doi:10.1016/j.chroma.2016.06.046

Cited by 16 publications

(9 citation statements)

References 30 publications

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“…The incorporation of PDA remarkably improved compatibility and adhesion between nano SiO 2 and PP matrix which is mainly responsible for excellent mechanical properties . The incorporation of modified SiO 2 nano‐particle SiO 2 @polydopamine also tremendously improved hydrophilicity of PP matrix that may contribute to dyeing of PP product . When 1% wt SiO 2 @polydopamine and a certain amount of β nucleating agent was added, the impact strength of composite reached the maximum value 12.60 k J/m 2 (improving 127% compared to pure PP), the bending strength reached 41.85 MPa, the bending modulus was 2192 MPa, the composite possessed hydrophilic performance with the water contact angle of 88.32°.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous enhancements of mechanical properties and hydrophilic properties of polypropylene via nano‐silicon dioxide modified by polydopamine

Qiu

Wang

Yang

et al. 2017

J of Applied Polymer Sci

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This study is focused on the development of high‐performance composite materials based on nano silicon dioxide (nano‐SiO2) modified by polydopamine (PDA). A facile one‐step method was developed to synthesize core–shell structured SiO2@polydopamine (PDA) nanospheres. During the synthesis, a PDA shell was simultaneously coated on the SiO2 nanospheres to form the core–shell nanostructure which was blended with polypropylene (PP) and β nucleating agent (β‐NA) to enhance both mechanical and hydrophilic properties. Nano‐SiO2 particles modified by PDA (SiO2@polydopamine) influence the crystallization of PP seriously. The results indicated that when 1%wt SiO2@polydopamine was added, the impact strength of composite reached the maximum value 12.60k J/m2 increasing 137% compared with PP, the bending strength and bending modulus decreased slightly reaching 41.85 MPa, and 2192 MPa, respectively, the composite possessed hydrophilic performance with the water contact angle of 88.32°. β nucleating agent was used in all formulations, the synergistic effect toward mechanical properties with SiO2@polydopamine was studied. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45004.

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Section: Introductionmentioning

confidence: 99%

Simultaneous enhancements of mechanical properties and hydrophilic properties of polypropylene via nano‐silicon dioxide modified by polydopamine

Qiu

Wang

Yang

et al. 2017

J of Applied Polymer Sci

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“…Lipids have various critical biological functions in cellular barriers, signal transduction, material transport, energy storage, cell differentiation, and apoptosis [11,12]. Lipids can be divided into classes and subclasses according to their head group and the type of connection between the head group and acyl chains [13]. The diversities in the head group and acyl chain of lipids lead to many individual lipid molecular species [14], including fatty acyls (FAs), glycerolipids (GLs), glycerophospholipids (GPs), sphingolipids (SPs), sterol lipids (STs), saccharolipids (SLs), prenol lipids (PRs), and polyketides (PKs).…”

Section: Introductionmentioning

confidence: 99%

Lipidomic alteration of plasma in cured COVID-19 patients using ultra high-performance liquid chromatography with high-resolution mass spectrometry

Bai¹,

Huang²,

Li³

et al. 2021

Bioscience Reports

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Background: The pandemic of novel coronavirus disease 2019 (COVID-19) has become a serious public health crisis worldwide. The symptoms of COVID-19 vary from mild to severe among different age groups, but the physiological changes related to COVID-19 are barely understood. Methods: In this study, a high-resolution mass spectrometry (HRMS)-based lipidomic strategy was used to characterize the endogenous plasma lipids for cured COVID-19 patients with different ages and symptoms. These patients were further divided into two groups: those with severe symptoms or who were elderly and relatively young patients with mild symptoms. In addition, automated lipidomic identification and alignment was conducted by LipidSearch software. Multivariate and univariate analyses were used for differential comparison. Results: Nearly 500 lipid compounds were identified in each cured COVID-19 group through LipidSearch software. At the level of lipid subclasses, patients with severe symptoms or elderly patients displayed dramatic changes in plasma lipidomic alterations, such as increased triglycerides and decreased cholesteryl esters. Some of these differential lipids might also have essential biological functions. Furthermore, the differential analysis of plasma lipids among groups was performed to provide potential prognostic indicators, and the change in signaling pathways. Conclusions: Dyslipidemia was observed in cured COVID-19 patients due to the viral infection and medical treatment, and the discharged patients should continue to do consolidation therapy. This work provides valuable knowledge about plasma lipid markers and potential therapeutic targets of COVID-19 and essential resources for further research on the pathogenesis of COVID-19.

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“…However, the derivatization reaction for biological samples, often in the liquid phase, is usually accompanied by shortcomings, such as time-consuming, excessive derivatization reagents and low derivatization efficiency. Qin et al [108] modified the method by firstly employing SiO 2 @PD_Ti 4+ microspheres to selectively enrich sugar phosphates and remove the excess number of other metabolites prior to derivatization, and then react with AEC based on solid-phase derivatization. This modification has significantly shortened derivatization time and reduced the interference of the residual derivatization reagents on the ionization efficiency, leading to three orders of magnitude improvement on the sensitivity for detection of sugar phosphates and making it possible to determine trace sugar phosphates in small amounts of biological fluids.…”

Section: Aminesmentioning

confidence: 99%

Progress and Challenges in Quantifying Carbonyl-Metabolomic Phenomes with LC-MS/MS

2021

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Carbonyl-containing metabolites widely exist in biological samples and have important physiological functions. Thus, accurate and sensitive quantitative analysis of carbonyl-containing metabolites is crucial to provide insight into metabolic pathways as well as disease mechanisms. Although reversed phase liquid chromatography electrospray ionization mass spectrometry (RPLC-ESI-MS) is widely used due to the powerful separation capability of RPLC and high specificity and sensitivity of MS, but it is often challenging to directly analyze carbonyl-containing metabolites using RPLC-ESI-MS due to the poor ionization efficiency of neutral carbonyl groups in ESI. Modification of carbonyl-containing metabolites by a chemical derivatization strategy can overcome the obstacle of sensitivity; however, it is insufficient to achieve accurate quantification due to instrument drift and matrix effects. The emergence of stable isotope-coded derivatization (ICD) provides a good solution to the problems encountered above. Thus, LC-MS methods that utilize ICD have been applied in metabolomics including quantitative targeted analysis and untargeted profiling analysis. In addition, ICD makes multiplex or multichannel submetabolome analysis possible, which not only reduces instrument running time but also avoids the variation of MS response. In this review, representative derivatization reagents and typical applications in absolute quantification and submetabolome profiling are discussed to highlight the superiority of the ICD strategy for detection of carbonyl-containing metabolites.

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Highly efficient solid-phase derivatization of sugar phosphates with titanium-immobilized hydrophilic polydopamine-coated silica

Cited by 16 publications

References 30 publications

Simultaneous enhancements of mechanical properties and hydrophilic properties of polypropylene via nano‐silicon dioxide modified by polydopamine

Simultaneous enhancements of mechanical properties and hydrophilic properties of polypropylene via nano‐silicon dioxide modified by polydopamine

Lipidomic alteration of plasma in cured COVID-19 patients using ultra high-performance liquid chromatography with high-resolution mass spectrometry

Progress and Challenges in Quantifying Carbonyl-Metabolomic Phenomes with LC-MS/MS

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