“…[3] The substituted thieno [2,3-b]indoles are useful for the treatment of epilepsy, neurological diseases such as Parkinson's disease and pain. [5] There are few methods for the synthesis of thieno [2,3-b]indoles in the literature, including deoxygenative cyclization of 2-(2-nitrophenyl)thiophene in refluxing triethyl phosphate, [6] oxidative cyclization of indolin-2-thiones, [7] radical or palladium-catalyzed cyc-lization of 3-(2-bromoindol-3yl)acrylonitriles, [8] condensation of 3-unsubstituted indolin-2-thione, [9] intramolecular NH/CH-coupling in benzo[b]thiophenes, [10] condensation of 1-alkylisatins and acetylated (hetero) arenes, [11] AlCl 3 -catalyzed recyclization of 2-(2-nitrocyabatophenyl)furanes, [12] and among others. [5] There are few methods for the synthesis of thieno [2,3-b]indoles in the literature, including deoxygenative cyclization of 2-(2-nitrophenyl)thiophene in refluxing triethyl phosphate, [6] oxidative cyclization of indolin-2-thiones, [7] radical or palladium-catalyzed cyc-lization of 3-(2-bromoindol-3yl)acrylonitriles, [8] condensation of 3-unsubstituted indolin-2-thione, [9] intramolecular NH/CH-coupling in benzo[b]thiophenes, [10] condensation of 1-alkylisatins and acetylated (hetero) arenes, [11] AlCl 3 -catalyzed recyclization of 2-(2-nitrocyabatophenyl)furanes, [12] and among others.…”