Recent investigations have shown that a non-separable Wiener filter, that is applied inside the motion-compensation loop, can improve the coding efficiency of hybrid video coding designs. In this paper, we study the application of separable Wiener filters. Our design includes the possibility to adaptively choose between the application of the vertical, horizontal, or combined filter. The simulation results verify that a separable in-loop Wiener filter is capable of providing virtually the same increase in coding efficiency as a non-separable Wiener filter, but at a significantly reduced decoder complexity