Highly elastomeric photocurable silk hydrogels

Kuang, Dajiang; Jiang, Fujian; Wu, Feng; Kaur, Kulwinder; Ghosh, Sourabh; Kundu, Subhas C.; Lu, Shenzhou

doi:10.1016/j.ijbiomac.2019.05.068

Cited by 34 publications

(13 citation statements)

References 47 publications

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“…[66,99,119] The typical materials used for stereolithography printing are resins. [77,119,120] Functional materials such as hydrogels [121][122][123] and photocurable polydimethylsiloxane (PDMS) [124][125][126] have also been demonstrated for stereolithography printing. However, stereolithography printing has limited applications for integrated wearable devices, especially for multimaterials printing.…”

Section: Ink-based Additive Nanomanufacturing Techniquesmentioning

confidence: 99%

Ink‐Based Additive Nanomanufacturing of Functional Materials for Human‐Integrated Smart Wearables

2020

Advanced Intelligent Systems

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Human-integrated devices include wearable and implantable devices for monitoring vital human signals or interacting with the human body. [1-3] The human-integrated devices needed to be tethered to the organs or the human skin for implementing their functions such as sensing and energy harvesting. [4-18] The economical, agile, customizable manufacturing, and integration of multifunctional device modules into networked systems with mechanical compliance and robustness will enable unprecedented human-integrated smart wearables [19-23] and usher in exciting opportunities in emerging technologies such as electronics, [24-29] wearable computation, [30-36] human-machine interface, [37-42] robotics, [43-48] and advanced healthcare. [49-54] The fabrication of stateof-the-art microelectronics involves hightemperature processing steps, which are generally incompatible with the flexible substrates (e.g., paper, polymer, fiber, etc.) [55-61] widely used in the wearable devices. Moreover, the current microfabrication technologies are not well positioned to process the emerging functional nanomaterials (e.g., nanowires [NWs] and 2D materials). [62-65] Such incomparability severely limits the pace of deploying these emerging materials (despite their unprecedented properties) in wearable and flexible device technologies. The additive manufacturing (AM) processes have emerged as potential candidates for addressing the earlier limitations of the current microfabrication technologies in fabricating flexible/wearable printed devices with diversified functionalities, e.g., energy harvesting/storage, sensing, actuation, and computation, leveraging advantages such as maskless processing, versatile ink formulation, low cost, low processing temperature, and scalability. [66-71] Researchers have devoted tremendous efforts to develop the related technologies, and several reviews have provided excellent discussions on the material formulation and process aspects of AM techniques. [63,72-79] However, to our best knowledge, there are few review reports about the ink-based additive nanomanufacturing of functional materials for human-integrated smart wearables. To fill this gap, here we review the recent progress in ink-based

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Section: Ink-based Additive Nanomanufacturing Techniquesmentioning

confidence: 99%

Ink‐Based Additive Nanomanufacturing of Functional Materials for Human‐Integrated Smart Wearables

2020

Advanced Intelligent Systems

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“…As a result, both in situ photocrosslinking and post-photocrosslinking have been intensively studied as a facile approach that can be potentially incorporated into 3D bioprinting processes for the rapid fabrication of SF-based 3D structures. [24][25][26] A deepened understanding of the photochemical characteristics of SF has inspired attempts of 3D printing SF-based, selfcrosslinked hydrogels without further tedious processing, [27][28][29] in light of the great potential of such custom-made 3D microand macro-constructs as candidate materials for prostheses 30 or biosensors. 31 It was found by these studies that the abundance of tyrosine in SF, or tyrosine residues, is a critical factor that determines the efficiency of SF self-crosslinking and the crosslink density of the resulting SF hydrogel network.…”

Section: Introductionmentioning

confidence: 99%

“…A deepened understanding of the photochemical characteristics of SF has inspired attempts of 3D printing SF-based, self-crosslinked hydrogels without further tedious processing, 27–29 in light of the great potential of such custom-made 3D micro- and macro-constructs as candidate materials for prostheses 30 or biosensors. 31 It was found by these studies that the abundance of tyrosine in SF, or tyrosine residues, is a critical factor that determines the efficiency of SF self-crosslinking and the crosslink density of the resulting SF hydrogel network.…”

Section: Introductionmentioning

confidence: 99%

Dityrosine-inspired photocrosslinking technique for 3D printing of silk fibroin-based composite hydrogel scaffolds

et al. 2022

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“…Kundu et al reported an SIPN hydrogel made of silk fibroin/polyacrylamide, and its compressive strength was 0.2 MPa . Lu et al reported a light-cured silk fibroin hydrogel and reached a compressive strength of 0.6 MPa . Khademhosseini et al developed a light-curing interpenetrating polymer network (IPN) hydrogel based on methacrylic gelatin and silk fibroin, with a compressive strength of 0.07 MPa .…”

Section: Introductionmentioning

confidence: 99%

“…18 Lu et al reported a light-cured silk fibroin hydrogel and reached a compressive strength of 0.6 MPa. 19 Khademhosseini et al developed a light-curing interpenetrating polymer network (IPN) hydrogel based on methacrylic gelatin and silk fibroin, with a compressive strength of 0.07 MPa. 12 Furthermore, SF has been blended with various synthetic polymers like poloxamer 407, polyurethane, poly(vinyl alcohol) (PVA), and natural macromolecules like gelatin, collagen, elastin, etc.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Properties of Semi-Interpenetrating Silk Fibroin Protein Hydrogels with Integrated Strength and Toughness

Chen

Sima

Liu

et al. 2021

ACS Appl. Polym. Mater.

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Two series of semi-interpenetrating network hydrogels (P(AAN-co-AAM)-SF and P(AA-co-AAM)-SF) were constructed through one-step blending of silk fibroin with sodium acrylate or acrylic acid followed by ultraviolet (UV)-initiated free-radical copolymerization. The resulting silk fibroin composite hydrogels exhibited excellent mechanical properties due to the semi-interpenetrating network hydrogel formed by sodium polyacrylate and silk fibroin. Specifically, the P(AAN-co-AAM)-SF hydrogel showed a high fracture stress of 1.01 MPa, an elongation at break of 2000%, a high compressive strength of 17 MPa, and could be compressed up to 200 cycles without damage. Compared with other silk fibroin hydrogels, this work was in a leading position in terms of mechanical properties and antidrying ability. In addition, silk fibroin-based hydrogels showed no cytotoxicity, certain UV-shielding ability, and were specifically poured into pig tracheal sections, indicating the potential for future use as biological materials.

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Highly elastomeric photocurable silk hydrogels

Cited by 34 publications

References 47 publications

Ink‐Based Additive Nanomanufacturing of Functional Materials for Human‐Integrated Smart Wearables

Ink‐Based Additive Nanomanufacturing of Functional Materials for Human‐Integrated Smart Wearables

Dityrosine-inspired photocrosslinking technique for 3D printing of silk fibroin-based composite hydrogel scaffolds

Preparation and Properties of Semi-Interpenetrating Silk Fibroin Protein Hydrogels with Integrated Strength and Toughness

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