Highly emissive hybrid mesoporous organometallo-silica nanoparticles for bioimaging

Abstract

The production of Mesoporous Silica Nanoparticles (MSNs) with uniform textural characteristics and imaging properties in the large scale is still a challenge. Thus, the design of simple and scalable methods...

Delivery of miR-200c-3p Using Tumor-Targeted Mesoporous Silica Nanoparticles for Breast Cancer Therapy

“…Thus, the delivery in cells remains the most significant hurdle in using miRNAs as therapeutic agents. , In this scenario, nanoparticles are potential tools for miRNA pharmacokinetics improvement, since they can avoid miRNA degradation, can ensure their delivery to the cytosol, accumulate in tumors thanks to the enhanced permeability and retention (EPR) effect, and could additionally be functionalized to target specific cells. , In particular, mesoporous silica nanoparticles (MSNs) are suitable candidates as miRNA delivery vectors . MSNs are biocompatible and biodegradable , materials with a porous structure, large specific surface area and volume, chemically and thermally stable, and can be equipped with molecular gates (also known as gatekeepers or nanovalves) able to regulate cargo delivery in response to predefined physical, chemical, or biochemical stimuli. − Thanks to their advantageous properties, MSNs have become one of the most important platforms for drug-controlled release , and they have been used in many biomedical applications, such as drug, , gene, , and RNA , delivery; bioimaging; , chemical communication; , stigmergy; , nanomotors; , biosensing; , and theragnostic and tissue engineering. , MSNs can be functionalized not only with molecular gates but also with other organic ligands and inorganic nanoparticles to provide them versatile chemical and physical properties, , which made them extraordinary versatile nanoplatforms.…”

Photoluminescent Silica Nanostructures and Nanohybrids

“…Another important aspect of SiO 2 NPs, by virtue of their porous structures and �SiÀ OH groups, is their ability to act as host for organic and/or inorganic molecules, quantum dots and biomolecules. [22][23][24][25][26][27][28] Host-guest systems produced thus are attractive from the perspective of photovoltaics, sensing and biology. [29][30][31][32][33][34] However, in such host-guest material, SiO 2 is not actively involved in the photophysics process and only functions as the matrix.…”

“…[29][30][31][32][33][34] However, in such host-guest material, SiO 2 is not actively involved in the photophysics process and only functions as the matrix. [22,23,25] Covalent functionalization of the surface is possible utilizing simple surface silanol (�SiÀ OH) chemistry. High thermal resistivity and chemical inertness provide chemical and structural stability to SiO 2 NPs in electronic, optical and optoelectronic devices.…”

“…Another important aspect of SiO 2 NPs, by virtue of their porous structures and ≡Si−OH groups, is their ability to act as host for organic and/or inorganic molecules, quantum dots and biomolecules [22–28] . Host‐guest systems produced thus are attractive from the perspective of photovoltaics, sensing and biology [29–34] .…”

“…Host‐guest systems produced thus are attractive from the perspective of photovoltaics, sensing and biology [29–34] . However, in such host‐guest material, SiO 2 is not actively involved in the photophysics process and only functions as the matrix [22,23,25] . Covalent functionalization of the surface is possible utilizing simple surface silanol (≡Si−OH) chemistry.…”