Highly enantioselective [3+2] annulation of 4-amino-isoxazoles with quinone monoimines to access structurally diverse isoxazoline fused dihydrobenzofurans and antifungal evaluation

Recent Advances in the Domino Annulation Reaction of Quinone Imines

“…Furthermore, the reactions involving ethyl 4-acetate-isoxazol-5-amines and para -quinone monoimines afforded the bridged polycyclic scaffolds 95 in moderate yields with high ee values. Recently, the Zhang group also disclosed the dearomative cyclization reaction of 4-amino-isoxazoles 99 ( Scheme 22 ) [ 73 ]. Similar to their previous report, highly enantioselective [3 + 2] annulation of 4-amino-isoxazoles 99 with para -quinone monoimines 3 was achieved under the catalysis of chiral phosphoric acid C11 , providing access to structurally diverse isoxazoline-fused dihydrobenzofurans 100 with generally excellent enantioselectivities.…”