Highly flexible and porous silk fibroin microneedle wraps for perivascular drug delivery

Lee, JiYong; Jang, Eui Hwa; Kim, Jae Ho; Park, Seung-Hyun; Kang, Yosup; Park, Sang‐Hyun; Lee, KangJu; Kim, Junghwan; Youn, Young‐Nam; Ryu, WonHyoung

doi:10.1016/j.jconrel.2021.10.024

Cited by 39 publications

(24 citation statements)

References 84 publications

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“…Interestingly, synthetic biodegradable PDLLA and poly-caprolactone show no differences with or without balloon expansion. The acceleration of the sirolimus release from silk fibroin with balloon expansion indicates that plastic deformation of the silk fibroin layer loosens the interaction between silk fibroin and sirolimus, as shown in Figure 11 C. A similar previous study by Lee et al also demonstrated that sirolimus is slowly released from silk fibroin microneedle wraps owing to the interaction between the sirolimus and the silk fibroin [ 84 ]. In addition, the adhesion of human umbilical vein endothelial cells and platelets to silk fibroin was evaluated.…”

Section: Natural Biodegradable Polymerssupporting

confidence: 61%

Sirolimus Release from Biodegradable Polymers for Coronary Stent Application: A Review

Sasaki

Niidome

2022

Pharmaceutics

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Drug-eluting stents (DESs) are commonly used for the treatment of coronary artery disease. The evolution of the drug-eluting layer on the surface of the metal stent plays an important role in DES functionality. Here, the use of biodegradable polymers has emerged as an attractive strategy because it minimizes the occurrence of late thrombosis after stent implantation. Furthermore, understanding the drug-release behavior of DESs is also important for improving the safety and efficacy of stent treatments. Drug release from biodegradable polymers has attracted extensive research attention because biodegradable polymers with different properties show different drug-release behaviors. Molecular weight, composition, glass transition temperature, crystallinity, and the degradation rate are important properties affecting the behavior of polymers. Sirolimus is a conventional anti-proliferation drug and is the most widely used drug in DESs. Sirolimus-release behavior affects endothelialization and thrombosis formation after DES implantation. In this review, we focus on sirolimus release from biodegradable polymers, including synthetic and natural polymers widely used in the medical field. We hope this review will provide valuable up-to-date information on this subject and contribute to the further development of safe and efficient DESs.

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Section: Natural Biodegradable Polymerssupporting

confidence: 61%

Sirolimus Release from Biodegradable Polymers for Coronary Stent Application: A Review

Sasaki

Niidome

2022

Pharmaceutics

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“…In the latest study, they developed a sirolimus‐loaded flexible silk fibroin microneedle wrap using the transfer molding method. [ 101 ] Balloon‐injured rabbit abdominal aorta studies showed a significant reduction in neointimal formation. Microneedles permitted continuous delivery of anti‐proliferation drugs and substance exchange between blood vessels and extravascular tissues.…”

Section: Application Of Microneedles In Tissue Engineering and Regene...mentioning

confidence: 99%

Microneedle system for tissue engineering and regenerative medicine

Zhang

Kong

et al. 2023

Exploration

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Global increasing demand for high life quality and length facilitates the development of tissue engineering and regenerative medicine, which apply multidisciplinary theories and techniques to achieve the structural reconstruction and functional recovery of disordered or damaged tissues and organs. However, the clinical performances of adopted drugs, materials, and powerful cells in the laboratory are inescapably limited by the currently available technologies. To tackle the problems, versatile microneedles are developed as the new platform for local delivery of diverse cargos with minimal invasion. The efficient delivery, as well as painless and convenient procedure endow microneedles with good patient compliance in clinic. In this review, we first categorize different microneedle systems and delivery models, and then summarize their applications in tissue engineering and regenerative medicine mainly involving maintenance and rehabilitation of damaged tissues and organs. In the end, we discuss the advantages, challenges, and prospects of microneedles in depth for future clinical translations.

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“…It also causes minimal inflammation of host tissue, is low-cost, and easy to use [ 67 ]. Anti-proliferative [ 68 ], anti-inflammatory [ 69 , 70 ], anabolic [ 70 ], and anti-retroviral drugs [ 71 ] have been delivered using silk fibroin. Additional drugs include anti-inflammatory compounds such as curcumin [ 72 , 73 ] and chemotherapeutics [ 74 , 75 ].…”

Section: Natural Biopolymer Scaffolds For Therapeutic Ev Deliverymentioning

confidence: 99%

Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges

Leung

Shirazi

Cooper

et al. 2022

Cells

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In this review, we will discuss the current status of extracellular vesicle (EV) delivery via biopolymeric scaffolds for therapeutic applications and the challenges associated with the development of these functionalized scaffolds. EVs are cell-derived membranous structures and are involved in many physiological processes. Naïve and engineered EVs have much therapeutic potential, but proper delivery systems are required to prevent non-specific and off-target effects. Targeted and site-specific delivery using polymeric scaffolds can address these limitations. EV delivery with scaffolds has shown improvements in tissue remodeling, wound healing, bone healing, immunomodulation, and vascular performance. Thus, EV delivery via biopolymeric scaffolds is becoming an increasingly popular approach to tissue engineering. Although there are many types of natural and synthetic biopolymers, the overarching goal for many tissue engineers is to utilize biopolymers to restore defects and function as well as support host regeneration. Functionalizing biopolymers by incorporating EVs works toward this goal. Throughout this review, we will characterize extracellular vesicles, examine various biopolymers as a vehicle for EV delivery for therapeutic purposes, potential mechanisms by which EVs exert their effects, EV delivery for tissue repair and immunomodulation, and the challenges associated with the use of EVs in scaffolds.

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Highly flexible and porous silk fibroin microneedle wraps for perivascular drug delivery

Cited by 39 publications

References 84 publications

Sirolimus Release from Biodegradable Polymers for Coronary Stent Application: A Review

Sirolimus Release from Biodegradable Polymers for Coronary Stent Application: A Review

Microneedle system for tissue engineering and regenerative medicine

Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges

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