Highly Functionalized Modified Metal Oxides Polymeric Sensors for Potentiometric Determination of Letrozole in Commercial Oral Tablets and Biosamples

Abstract

The advanced and high-functional activities of magnesium oxide and copper oxide nanoparticles encourage the extensive use of these metal oxides as remarkable electroactive materials in electrochemical and sensing detections. The current study described a comparative sensing activity and selectivity of modified coated wire membrane sensors enriched with magnesium oxide and copper oxide nanoparticles for quantifying the breast cancer medication letrozole (LTZ) in its pharmaceutical form and human plasma. The fabricated sensors were based on the incorporation of LTZ with phosphomolybdic acid (PMA) to form the electroactive complex letrozole-phosphomolybate (LTZ-PM) in the presence of o-nitrophenyloctyl ether (o-NPOE) as a solvent mediator. Under optimum conditions, the modified sensors LTZ-PM-MgONPs and LTZ-PM-CuONPs demonstrated linear relationships of 1.0 × 10−8–1.0 × 10−2 and 1.0 × 10−10–1.0 × 10−2 mol L−1, respectively. Least square equations were calculated as EmV = (56.4 ± 0.7) log [LTZ] + 569.6 and EmV = (58.7 ± 0.3) log [LTZ] + 692.6 for LTZ-PM-MgONPs and LTZ-PM-CuONPs, respectively. The conventional type LTZ-PM showed a potential response EmV = (53.3 ± 0.5) log [LTZ] + 451.4 over concentration range of 1.0 × 10−6–1.0 × 10−2 mol L−1. The suggested sensors were successfully used to determine LTZ in pharmaceutical formulations and biosamples. Method validation ensured the suitability of the suggested potentiometric sensors.

Characterization of PVA-Enzyme Coated Indicator Electrodes GA coated again with PVC-KTpClPB-o-NPOE SEM-EDS, FTIR and XRD analysis

“…Morphology of indicator electrodes A1-4 61% EDS analysis peak intensity 4.3 keV weight percent tungsten 91.91%; morphology of indicator electrodes A1-4 66% EDS analysis peak intensity 2.5 keV weight percent tungsten 84.93%; morphology of indicator electrode A3-4 61% EDS analysis peak intensity 4.3 keV weight percent tungsten 95.98%; morphology indicator electrode A3-4 66% EDS analysis peak intensity 4.5 keV weight percent tungsten 79.81 %. This confirmed the high purity of the prepared tungsten (Shawky, 2021).…”

“…UV-Vis spectroscopy is the most useful and reliable technique for confirming the main characterization of the size, shape and stability of the nanostructures of metal oxides synthesized in liquid suspension. According to the analysis (Shawky, 2021;Al-Mohaimeed, et al, 2021) the increase in the absorption peak with respect to the wavelength has an effect on the increase in % Transmittance of the wave number.…”

“…XRD is an analytical method for estimating and measuring different crystal forms in the tested samples [Shawky, 2021]. (Alarfaj, N.A.…”

New Construction of Functionalized CuO/Al2O3 Nanocomposite-Based Polymeric Sensor for Potentiometric Estimation of Naltrexone Hydrochloride in Commercial Formulations

“…These techniques are also fast in terms of spending short analytical time, allowing on-line detecting of aqueous samples. The potentiometric technique is one of the most promising self-powered techniques in which the potential difference measurements are resulted from the accumulation of analytes under the electrostatic mechanism on the surface of the working electrode and the reference one [38]. Recently, various potentiometric sensors have been modified with metal, metal oxides and nanocomposites or coupled with biosensing electrodes to enhance their sensitivity and limits of detection [39,40].…”

Novel Copper Oxide-Integrated Carbon Paste Tirofiban Voltammetric Sensor

“…TIR is commonly prescribed to the patient; therefore, a simple, precise, sensitive, and reliable analytical protocol for TIR quantification in different samples is welcomed. Electroanalytical techniques based on tailormade electrochemical sensors have been proven to be an excellent choice for monitoring pharmaceutical and bioactive compounds in different medicinal formulations and biological samples. − With the advantages of acceptable sensitivity, relatively short analysis time, and simple instrumentation equipment, the electroanalytical approaches can contribute to the analysis of pharmaceuticals in quality control laboratories as an alternative or the committee with other spectrometric and chromatographic techniques. Moreover, exploring the electrochemical behavior of a drug molecule may be useful for explanation of its vivo redox processes, metabolic fate, or pharmacological activity.…”