Harmonic transponder sensors, receiving radiofrequency (RF) signal and converting it to a modulated second harmonic, have been demonstrated to be effective for signal interrogation in environments with strong clutters. Here, we propose a compact dual-resonance microstrip antenna consisting of an elliptical patch loaded with shorting pins. Such an antenna utilizes the TM e110 resonant mode to intercept the perpendicularly-polarized fundamental tone (2.86 GHz) and uses the TM o110 resonant mode to retransmits the parallelly-polarized second harmonic (5.72 GHz). Moreover, we have developed a harmonic-based wireless liquid sensor comprising the proposed antenna and a micromachined liquid channel. Our measurement results show that even in the noisy environment, the second harmonic strength can precisely indicate the dielectric property of liquid filled in the microfluidic tank (e.g., acetone-water mixtures with various concentrations). However, a similar setup without frequency and polarization modulations (i.e., linear and passive backscatter tag) fails to provide a sensitive and quantitative measurement of liquid property. The proposed low-profile dual-resonance antenna with sensing capability will pave the way for the development of harmonic sensors and nonlinear radio-frequency identification (RFID) tags.