Highly luminescent and photostable near-infrared fluorescent polymer dots for long-term tumor cell tracking in vivo

Xiong, Liqin; Guo, Yixiao; Zhang, Yimin; Cao, Fengwen

doi:10.1039/c5tb02348c

Cited by 32 publications

(28 citation statements)

References 32 publications

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“…28,30,31,34 Xiong et al developed similar MEH-PPV/NIR775-based CPNs as Rao’s group that could be used for tumor cell imaging in vitro and in vivo. 33,35 …”

Section: Nir-emissive Pdots and Cpnsmentioning

confidence: 99%

Recent Advances in the Development of Highly Luminescent Semiconducting Polymer Dots and Nanoparticles for Biological Imaging and Medicine

et al. 2016

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“…28,30,31,34 Xiong et al developed similar MEH-PPV/NIR775-based CPNs as Rao’s group that could be used for tumor cell imaging in vitro and in vivo. 33,35 …”

Section: Nir-emissive Pdots and Cpnsmentioning

confidence: 99%

Recent Advances in the Development of Highly Luminescent Semiconducting Polymer Dots and Nanoparticles for Biological Imaging and Medicine

et al. 2016

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“…Polyfluorene‐based π‐conjugated polymer nanoparticles with ultrabright fluorescence have been successfully applied for cell labeling and tracking, bioorthogonal tagging, and in vivo tumor targeting . Accordingly, we choose polyfluorene polymers to modify their side chains with oxetane groups.…”

Section: Figurementioning

confidence: 99%

“…Polyfluorene-based p-conjugated polymer nanoparticles with ultrabright fluorescenceh ave been successfully applied for cell labeling and tracking, [18,19] bioorthogonal tagging, [20] and in vivo tumort argeting. [21,22] Accordingly,w echoose polyfluorene polymers to modify their side chains with oxetane groups.M oreover,P EG has been approved by the U.S. Food and Drug Administration for clinicala pplicationsi nv arious biomedicala reas owing to its non-toxicity and non-immunogenicity.P EGylated nanoparticles exhibited important characteristics for in vivo applications such as the increased blood circulation lifetimea sw ell as the decreased clearance by the body's reticuloendothelial system.…”

mentioning

confidence: 99%

Light‐Induced PEGylation and Functionalization of Semiconductor Polymer Dots

et al. 2017

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As emiconductor polymer with side-chain oxetane groups was synthesized to form highly fluorescent, functionalized, andu ltra-stablep olymer dots (Pdots). A facile light-induced strategy covalently links functional polyethylene glycol (PEG) molecules to polymer dots while simultaneously providing functional groups for bioconjugation. The influence of photo-crosslinkable sidechains and PEG molecules on the properties and performance of Pdots was systematically investigated. The Pdots functionalized by photo-crosslinking show specific labeling and negligible non-specific binding as compared to non-functionalized Pdots. The resultsp rovide av iable strategy for nanoparticle assembly and functionalization.Semiconducting polymers have attracted considerable interest in both optoelectronic and biomedical applications over past decades. While they were originally developed for optoelectronic devices,t he adaptation of semiconducting polymers into nanoparticles has yielded ar apidlyi ncreasing number of applicationso ft he polymer dots (Pdots)i nb iomedical theranostics.[1-4] The attractiveness of Pdots foro pticali maging, sensing, and phototherapy is due to their superior characteristics, such as large absorption coefficients, excellent photostability,b iocompatibility,a nd suitability for the efficient generation of either photoluminescence, photoacoustic waves, or reactive oxygen species (ROS).[5-8] Such versatile and extraordinary properties have motivated researchers to explore the multifunctional Pdots for biological applications. Significant efforts have recently been focusedo ns ynthesizing new conjugated polymers, [9,10] developing functionalization strategies, [11,12] and designing signal transduction/amplification schemes. [13,14] The usefulness of Pdots in biological applications is strongly dependento nt he quality of the surfacef unctionalization to enables pecific recognition. Hence, many strategies have been implemented to modifyP dot surfaces with different functional molecules, for example, PEGylated lipids and amphiphilic polymers. [15,16] These functional molecules consist of hydrophobic components and hydrophilic segmentsw ith functional groups (e.g.,p olyethylene glycol,a mines, and carboxylic acids). During the Pdot formation, the hydrophobic segments are physically associated with polymer nanoparticles, while the hydrophilic chains extend partlyi nto the aqueous environment for further bioconjugation. Chiu's group developed ad irect functionalization strategy by modifying the side chain of the conjugated polymer.[17] Pdots formed from such functional polymers would directly have surface reactive groups for bioconjugation. In this strategy,the density of the side-chain functional groupss hould be well controlled to preventt he formationo farelatively loose structure, which can significantly affect nanoparticle stability and fluorescenceb rightness. However, challenges remain in the functionalization of Pdot surfaces for biomedical applications. Ideal semiconducting polymer nanoparticles ...

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“…[10,[41][42][43][44] By taking advantage of the facile surface functionalization of Pdots, NIR Pdots conjugated with biomolecules (i.e., antibody and folic acid) can bind to specific cell surfaces or tissues. [10,[41][42][43][44] By taking advantage of the facile surface functionalization of Pdots, NIR Pdots conjugated with biomolecules (i.e., antibody and folic acid) can bind to specific cell surfaces or tissues.…”

Section: In Vitro and In Vivo Bioimaging With Nir Pdotsmentioning

confidence: 99%

Semiconducting polymer dots as near‐infrared fluorescent probes for bioimaging and sensing

Tsai

Chan

2018

J Chinese Chemical Soc

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In recent years, semiconducting polymer dots (Pdots) have emerged as a new type of ultrabright fluorescent probes, which have been proved to be very useful for biomedical imaging. Pdots possess several exceptional advantages including high fluorescence brightness, fast radiative rate, excellent photostability, and negligible cytotoxicity. Among these new types of Pdots, the near‐infrared (NIR) fluorescent Pdots appear to be the most urgent and important owing to their promising deep‐tissue imaging in the clinic. This mini‐review highlights the recent progress in the design of NIR‐emitting Pdots and their biomedical applications both in vitro and in vivo.

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Highly luminescent and photostable near-infrared fluorescent polymer dots for long-term tumor cell tracking in vivo

Cited by 32 publications

References 32 publications

Recent Advances in the Development of Highly Luminescent Semiconducting Polymer Dots and Nanoparticles for Biological Imaging and Medicine

Recent Advances in the Development of Highly Luminescent Semiconducting Polymer Dots and Nanoparticles for Biological Imaging and Medicine

Light‐Induced PEGylation and Functionalization of Semiconductor Polymer Dots

Semiconducting polymer dots as near‐infrared fluorescent probes for bioimaging and sensing

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