Highly Luminescent Conjugated Polymer Nanoparticles for Imaging and Therapy

doi:10.13179/canchemtrans.2013.01.01.0015

Cited by 13 publications

(2 citation statements)

References 32 publications

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“…The sensor was proposed to be handy but shows a poor detection range at the parts per million level only. Some of the researchers have also reported the fluorescence based color change analysis system, which have high sensitivity but get limited by the problem of dye-bleaching. , For example, Karak et al have reported a xanthone based Pb 2+ selective turn on fluorescent probe for living cell staining …”

Section: Introductionmentioning

confidence: 99%

Equipment-Free, Single-Step, Rapid, “On-Site” Kit for Visual Detection of Lead Ions in Soil, Water, Bacteria, Live Cells, and Solid Fruits Using Fluorescent Cube-Shaped Nitrogen-Doped Carbon Dots

Choudhary

Patra

Madhuri

et al. 2016

ACS Sustainable Chem. Eng.

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In this work, we have designed an equipment free, single-step, rapid, cost-effective, "in-house", and "outdoor" kit for visual detection of lead ions (Pb 2+ ) in various real samples viz., soil, water, bacteria, live cells, and solid fruits based on cube-shaped fluorescent carbon dots. The cube-shaped nitrogen-doped carbon dots (CCDs) were prepared using calcein dye as precursor and have potential to be used as better and stable replacement of commercially available dyes. For the visual detection of Pb 2+ , the color of the CCDs changes from yellowish to brown in solution and a limit of detection (LOD) of 10.0 μg L −1 was obtained for the naked eye. In addition, the same CCD solution was also coated on a filter paper strip to fabricate an easy-toprepare paper sensor. The paper sensor was used to identify the Pb 2+ in real samples which proves their applicability toward in-situ on-site detection. In addition, the prepared strip sensor was successfully implemented for analysis of lead ions inside the solid fruit also. For quantitative detection, a photoluminescence (PL) study was carried out for trace level determination of Pb 2+ with LOD of 2.21 ng L −1 . Both the visual as well as PL study also suggested that the results obtained from the CCD sensing probe is free from any interference. We also incubated the CCDs into live cells (E. coli and MCF-7) through endocytosis and monitored the changes in Pb 2+ levels within cells. The study demonstrates the role of prepared fluorescent probe for live cell bioimaging and intracellular detection of metal ions.

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Section: Introductionmentioning

confidence: 99%

Equipment-Free, Single-Step, Rapid, “On-Site” Kit for Visual Detection of Lead Ions in Soil, Water, Bacteria, Live Cells, and Solid Fruits Using Fluorescent Cube-Shaped Nitrogen-Doped Carbon Dots

Choudhary

Patra

Madhuri

et al. 2016

ACS Sustainable Chem. Eng.

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“…Pdots also possess good biocompatibility, tunable optical properties and surface properties and colloidal dimensions. Several reviews and perspectives have described conjugated polymer nanoparticles (CPN) in the past decade, − but we consider only some of these CPNs to be Pdots. As described in our previous review, Pdots connote both small particle size and high brightness.…”

mentioning

confidence: 99%

Recent Advances in the Development of Highly Luminescent Semiconducting Polymer Dots and Nanoparticles for Biological Imaging and Medicine

et al. 2016

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Recent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imaging

2017

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Molecular probes that change their signals in response to the target of interest have a critical role in fundamental biology and medicine. Semiconducting polymer nanoparticles (SPNs) have recently emerged as a new generation of purely organic photonic nanoagents with desirable properties for biological applications. In particular, tunable optical properties of SPNs allow them to be developed into photoluminescence, chemiluminescence, and photoacoustic probes, wherein SPNs usually serve as the energy donor and internal reference for luminescence and photoacoustic probes, respectively. Moreover, facile surface modification and intraparticle engineering provide the versatility to make them responsive to various biologically and pathologically important substances and indexes including small‐molecule mediators, proteins, pH and temperature. This article focuses on recent advances in the development of SPN‐based activatable molecular probes for sensing and imaging. The designs and applications of these probes are discussed in details, and the present challenges to further advance them into life science are also analyzed.

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Highly Luminescent Conjugated Polymer Nanoparticles for Imaging and Therapy

Cited by 13 publications

References 32 publications

Equipment-Free, Single-Step, Rapid, “On-Site” Kit for Visual Detection of Lead Ions in Soil, Water, Bacteria, Live Cells, and Solid Fruits Using Fluorescent Cube-Shaped Nitrogen-Doped Carbon Dots

Equipment-Free, Single-Step, Rapid, “On-Site” Kit for Visual Detection of Lead Ions in Soil, Water, Bacteria, Live Cells, and Solid Fruits Using Fluorescent Cube-Shaped Nitrogen-Doped Carbon Dots

Recent Advances in the Development of Highly Luminescent Semiconducting Polymer Dots and Nanoparticles for Biological Imaging and Medicine

Recent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imaging

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