Highly luminescent water-soluble quaternary Zn–Ag–In–S quantum dots for tumor cell-targeted imaging

Deng, Dawei; Cao, Jie; Qu, Lingzhi; Achilefu, Samuel; Gu, Yueqing

doi:10.1039/c3cp00046j

Cited by 90 publications

(95 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ZZC does not contain cytotoxic elements (such as Cd and Se), thus the cytotoxicity of R8-ZZC to ASCs appears to be extremely suppressed in comparison to CdSe-based QDs18. The main cause appears to be due to the absence of toxicity elements.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Labeling and in vivo visualization of transplanted adipose tissue-derived stem cells with safe cadmium-free aqueous ZnS coating of ZnS-AgInS2 nanoparticles

Ogihara

Yukawa

Kameyama

et al. 2017

Sci Rep

View full text Add to dashboard Cite

The facile synthesis of ZnS-AgInS2 (ZAIS) as cadmium-free QDs and their application, mainly in solar cells, has been reported by our groups. In the present study, we investigated the safety and the usefulness for labeling and in vivo imaging of a newly synthesized aqueous ZnS-coated ZAIS (ZnS-ZAIS) carboxylated nanoparticles (ZZC) to stem cells. ZZC shows the strong fluorescence in aqueous solutions such as PBS and cell culture medium, and a complex of ZZC and octa-arginine (R8) peptides (R8-ZZC) can achieve the highly efficient labeling of adipose tissue-derived stem cells (ASCs). The cytotoxicity of R8-ZZC to ASCs was found to be extremely low in comparison to that of CdSe-based QDs, and R8-ZZC was confirmed to have no influence on the proliferation rate or the differentiation ability of ASCs. Moreover, R8-ZZC was not found to induce the production of major inflammatory cytokines (TNF-α, IFN-γ, IL-12p70, IL-6 and MCP-1) in ASCs. Transplanted R8-ZZC-labeled ASCs could be quantitatively detected in the lungs and liver mainly using an in vivo imaging system. In addition, high-speed multiphoton confocal laser microscopy revealed the presence of aggregates of transplanted ASCs at many sites in the lungs, whereas individual ASCs were found to have accumulated in the liver.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Thus, the development of novel QDs with extremely low cytotoxicity (especially Cd-free alternatives) is necessary for further advancement of QD technology15161718. There have been some reports about the cadmium-free QDs such as carbon or CuInS 2 /ZnS QDs192021.…”

mentioning

confidence: 99%

Labeling and in vivo visualization of transplanted adipose tissue-derived stem cells with safe cadmium-free aqueous ZnS coating of ZnS-AgInS2 nanoparticles

Ogihara

Yukawa

Kameyama

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…However, in 2011 Zhang and colleagues synthesized a quaternary QD system ZnAgInSe with PLQY of >70% . Then, two years later, Deng et al demonstrated the ability to maintain a PLQY as high as 50% while tuning ZnAgInSe QD emission from 660 to 800 nm in order to reach the NIR‐I region that is useful for in vivo imaging by varying the Zn:Ag precursor ratio . In 2017, Deng et al then used NIR‐I ZnAgInSe/ZnS quaternary core–shell QD nanoparticles with sulfobetaine‐poly(isobutylene‐ alt ‐maleic anhydride)–histimine (SPH) polymer conjugated on the surface for cancer imaging.…”

Section: Preclinical Quantum Dot Imaging In Cancermentioning

confidence: 99%

Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents

et al. 2018

View full text Add to dashboard Cite

Approximately 1.7 million new cases of cancer will be diagnosed this year in the United States leading to 600 000 deaths. Patient survival rates are highly correlated with the stage of cancer diagnosis, with localized and regional remission rates that are much higher than for metastatic cancer. The current standard of care for many solid tumors includes imaging and biopsy with histological assessment. In many cases, after tomographical imaging modalities have identified abnormal morphology consistent with cancer, surgery is performed to remove the primary tumor and evaluate the surrounding lymph nodes. Accurate identification of tumor margins and staging are critical for selecting optimal treatments to minimize recurrence. Visible, fluorescent, and radiolabeled small molecules have been used as contrast agents to improve detection during real-time intraoperative imaging. Unfortunately, current dyes lack the tissue specificity, stability, and signal penetration needed for optimal performance. Quantum dots (QDs) represent an exciting class of fluorescent probes for optical imaging with tunable optical properties, high stability, and the ability to target tumors or lymph nodes based on surface functionalization. Here, state-of-the-art biocompatible QDs are compared with current Food and Drug Administration approved fluorophores used in cancer imaging and a perspective on the pathway to clinical translation is provided.

show abstract

“…[137] As such, it is not surprising that there are examples of the hydrothermal synthesis of I-III-VI family semiconductor quantum dots. [138] In 2013, Deng et al synthesized ZnAgInS quantum dots with ab est quantum yield of~30 %b y boiling an aqueous solution of zinc acetate, silver nitrate, indium acetate with one of av ariety of sulfur precursors (thioacetamides, sodium sulfide,t hiourea,o rs odium thiosulfate) in presenceo fg lutathione as surface-passivatingr eagent. [138a] The glutathione ligands were later replaced with functionalized PEGs that allowed the materials to be conjugated to folic acid and RGD peptide.…”

Section: Hydrothermal Synthesismentioning

confidence: 99%

Synthetic Developments of Nontoxic Quantum Dots

Das

Snee

2015

ChemPhysChem

View full text Add to dashboard Cite

Semiconductor nanocrystals, or quantum dots (QDs), are candidates for biological sensing, photovoltaics, and catalysis due to their unique photophysical properties. The most studied QDs are composed of heavy metals like cadmium and lead. However, this engenders concerns over heavy metal toxicity. To address this issue, numerous studies have explored the development of nontoxic (or more accurately less toxic) quantum dots. In this Review, we select three major classes of nontoxic quantum dots composed of carbon, silicon and Group I-III-VI elements and discuss the myriad of synthetic strategies and surface modification methods to synthesize quantum dots composed of these material systems.

show abstract

Highly luminescent water-soluble quaternary Zn–Ag–In–S quantum dots for tumor cell-targeted imaging

Cited by 90 publications

References 40 publications

Labeling and in vivo visualization of transplanted adipose tissue-derived stem cells with safe cadmium-free aqueous ZnS coating of ZnS-AgInS2 nanoparticles

Labeling and in vivo visualization of transplanted adipose tissue-derived stem cells with safe cadmium-free aqueous ZnS coating of ZnS-AgInS2 nanoparticles

Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents

Synthetic Developments of Nontoxic Quantum Dots

Contact Info

Product

Resources

About