2005
DOI: 10.1371/journal.pbio.0030068
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Highly Nonrandom Features of Synaptic Connectivity in Local Cortical Circuits

Abstract: How different is local cortical circuitry from a random network? To answer this question, we probed synaptic connections with several hundred simultaneous quadruple whole-cell recordings from layer 5 pyramidal neurons in the rat visual cortex. Analysis of this dataset revealed several nonrandom features in synaptic connectivity. We confirmed previous reports that bidirectional connections are more common than expected in a random network. We found that several highly clustered three-neuron connectivity pattern… Show more

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Cited by 1,396 publications
(2,014 citation statements)
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References 66 publications
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“…the majority of connections are weak and the rare strong ones have a high probability of being bidirectional 3 . However, standard models of STDP 16 do not exhibit stable bidirectional connections 23,34 .…”
Section: Functional Implicationsmentioning
confidence: 99%
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“…the majority of connections are weak and the rare strong ones have a high probability of being bidirectional 3 . However, standard models of STDP 16 do not exhibit stable bidirectional connections 23,34 .…”
Section: Functional Implicationsmentioning
confidence: 99%
“…Moreover it is unclear how the interplay of coding and plasticity yield the functional connectivity patterns seen in experiments. In particular, the presence or absence of bidirectional connectivity between cortical pyramidal neurons seems to be contradictory across experimental preparations in visual 3 or somatosensory cortex 4 . Recent experiments have shown that STDP is strongly influenced by postsynaptic voltage before action potential firing 18 , but could not answer the question whether spike timing dependence is a direct consequence of voltage dependence, or the manifestation of an independent process.…”
Section: Introductionmentioning
confidence: 99%
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“…Regarding the neural correlate of memory, potential memory items were found, for example, in songbirds during song and recapitulation as stereotypical sequences of spike burst (Hahnloser et al 2002) or during a spatial task, as spatiotemporal patterns (Harris et al 2003) in the hippocampus. Additionally, typical connectivity structures, so-called motifs, were measured in the cortex (Song et al 2005;Perin et al 2011). However, it is not clear whether spatiotemporal patterns or motifs are memory items [or cell assemblies, see (6)] and whether they are subject to long-term plasticity as suggested by Hebb.…”
Section: Links Between Time Scales Of Memory and Physiologymentioning
confidence: 99%
“…The entries with asterisks are taken from Lefort et al (2009 reported a decrease from 9% probability of two cells within ± 25 µm of each other being connected, to 1% at distances > 100 µm for p II/III -p II/III synapses in visual and somatosensory cortex. However, Song et al (2005) reported that the probability of connection does not depend systematically on the distance in the same neuronal type in the visual cortex. In support of the latter, Lefort et al (2009) found no significant drop in connectivity over the distances explored in a single mouse barrel.…”
Section: Connection Probabilities and Delaysmentioning
confidence: 99%