Highly oxidized guaiane 12(8),15(6)-dilactones with neuroprotective activities from the roots of Lindera aggregata (Sims) Kosterm

Ma, Lie-Feng; Lou, Si-Qing; Chen, Hong-Yu; Luo, Di; Guo, Lu; Chen, Ning-Yu; Wu, Rui; Fang, Luo; Zhan, Zha-Jun

doi:10.1016/j.phytochem.2024.114150

Phytochemistry

2024

DOI: 10.1016/j.phytochem.2024.114150

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Highly oxidized guaiane 12(8),15(6)-dilactones with neuroprotective activities from the roots of Lindera aggregata (Sims) Kosterm

Lie-Feng Ma,

Si-Qing Lou,

Hong-Yu Chen

et al.

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Cited by 2 publications

References 32 publications

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Lindera aggregata improves intestinal function and alleviates depressive behaviors through the BDNF/TrkB/CREB signaling pathway induced by CUMS in mice

Wang,

Zhang,

Xie

et al. 2025

Brain Research

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Lindera aggregata improves intestinal function and alleviates depressive behaviors through the BDNF/TrkB/CREB signaling pathway induced by CUMS in mice

Wang,

Zhang,

Xie

et al. 2025

Brain Research

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Vicinal Diol Sesquiterpenes from Cinnamomum migao with Neuroprotective Effects in PC12 Cells

Zhou,

Chen,

Yang

et al. 2024

IJMS

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In the ongoing search for new vicinal diol natural products, four new (Migaones A–D, 1–4) and four known (5–8) vicinal diol sesquiterpenoids were isolated from the branches and leaves of Cinnamomum migao. Their structures were unequivocally determined by comprehensive spectroscopic analyses (HRESIMS, 1D, and 2D NMR), single-crystal X-ray diffraction, electronic circular dichroism calculations, and comparison with existing literature data. All compounds isolated from C. migao possess vicinal diol structural units except compound 2. The newly isolated compounds (1–4) were evaluated for their neuroprotective activity using the PC12 cell injury model induced by N-methyl-daspartate acid (NMDA) and compounds 1–2 showing moderate neuroprotective activity against NMDA-induced neurotoxicity. Furthermore, molecular docking studies indicated that the most active compound 2 binds to the active site of the NMDA receptor via hydrogen bonds and hydrophobic interactions.

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Highly oxidized guaiane 12(8),15(6)-dilactones with neuroprotective activities from the roots of Lindera aggregata (Sims) Kosterm

Cited by 2 publications

References 32 publications

Lindera aggregata improves intestinal function and alleviates depressive behaviors through the BDNF/TrkB/CREB signaling pathway induced by CUMS in mice

Lindera aggregata improves intestinal function and alleviates depressive behaviors through the BDNF/TrkB/CREB signaling pathway induced by CUMS in mice

Vicinal Diol Sesquiterpenes from Cinnamomum migao with Neuroprotective Effects in PC12 Cells

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