Highly Oxygenated Meroterpenoids from Fruiting Bodies of the Mushroom <i>Tricholoma terreum</i>

Yin, Xia; Feng, Tao; Li, Zhenghui; Dong, Zhibao; Li, Yan; Liu, Ji Kai

doi:10.1021/np400359y

Cited by 37 publications

(40 citation statements)

References 28 publications

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“…Plant terpenoids are used widely in traditional herbal remedies and their anti-bacterial, anti-cancerous and other pharmaceutical functions are under investigation [27]. It has been demonstrated that terpenoids extracted from mushrooms possess anti-tumor effects by directly suppressing cancer cell growth and invasion [28]. Among terpenoids, triterpenoids are ones that possess anti-tumor effects, which are mediated through inhibition of tumor cell proliferation and induction of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Suppression of Tumor Growth by Pleurotus ferulae Ethanol Extract through Induction of Cell Apoptosis, and Inhibition of Cell Proliferation and Migration

et al. 2014

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Cancer is the second leading cause of death worldwide. Edible medicinal mushrooms have been used in traditional medicine as regimes for cancer patients. Recently anti-cancer bioactive components from some mushrooms have been isolated and their anti-cancer effects have been tested. Pleurotus ferulae, a typical edible medicinal mushroom in Xinjiang China, has also been used to treat cancer patients in folk medicine. However, little studies have been reported on the anti-cancer components of Pleurotus ferulae. This study aims to extract bioactive components from Pleurotus ferulae and to investigate the anti-cancer effects of the extracts. We used ethanol to extract anti-cancer bioactive components enriched with terpenoids from Pleurotus ferulae. We tested the anti-tumour effects of ethanol extracts on the melanoma cell line B16F10, the human gastric cancer cell line BGC 823 and the immortalized human gastric epithelial mucosa cell line GES-1 in vitro and a murine melanoma model in vivo. Cell toxicity and cell proliferation were measured by MTT assays. Cell cycle progression, apoptosis, caspase 3 activity, mitochondrial membrane potential (MMP), migration and gene expression were studied in vitro. PFEC suppressed tumor cell growth, inhibited cell proliferation, arrested cells at G0/G1 phases and was not toxic to non-cancer cells. PFEC also induced cell apoptosis and necrosis, increased caspase 3 activity, reduced the MMP, prevented cell invasion and changed the expression of genes associated with apoptosis and the cell cycle. PFEC delayed tumor formation and reduced tumor growth in vivo. In conclusion, ethanol extracted components from Pleurotus ferulae exert anti-cancer effects through direct suppression of tumor cell growth and invasion, demonstrating its therapeutic potential in cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Suppression of Tumor Growth by Pleurotus ferulae Ethanol Extract through Induction of Cell Apoptosis, and Inhibition of Cell Proliferation and Migration

et al. 2014

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“…Inhibition of the proliferation of K562 and HepG2 tumor cells [68] Tricholoma terreum Four meroterpenoids, terreumols A-D Cytotoxicities against five human cancer cell lines [69] Agrocybe aegerita Lectin Inhibition of human and mouse tumor cells via inducing apoptosis [70] Albatrellus confluens Grifolin…”

Section: Mushrooms Bioactive Compound(s) Effects Referencesmentioning

confidence: 99%

Bioactivities and Health Benefits of Mushrooms Mainly from China

et al. 2016

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Many mushrooms have been used as foods and medicines for a long time. Mushrooms contain polyphenols, polysaccharides, vitamins and minerals. Studies show that mushrooms possess various bioactivities, such as antioxidant, anti-inflammatory, anticancer, immunomodulatory, antimicrobial, hepatoprotective, and antidiabetic properties, therefore, mushrooms have attracted increasing attention in recent years, and could be developed into functional food or medicines for prevention and treatment of several chronic diseases, such as cancer, cardiovascular diseases, diabetes mellitus and neurodegenerative diseases. The present review summarizes the bioactivities and health benefits of mushrooms, and could be useful for full utilization of mushrooms.

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“…are reported to be used as a source of immunostimulants, antitumor agents and medicinal adaptogens (Nitha et al 2007). Some compounds extracted from Tricholoma terreum were found to have cytotoxic effects against five human cancer cell lines (Yin et al 2013). Cantharellus cibarius is a beneficial nutrient for human health with high levels of vitamins B and C (Muszynska et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Fatty acid composition and antioxidant capacity of some medicinal mushrooms in Turkey

Türkekul

Çetin

Elmastaş

2017

JABC

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Turkey has a very rich fungal flora due to its phytogeographical position. The screening of chemical content and active substances of mushrooms becomes an important subject not only for Turkey but also for all over the world. In the last decade, Analyses on phytochemical and biological activity of fungi have gradually increased as a result of improvement in the number and quality of facilities. In the scope of the present research, four medicinal mushrooms; Morchella elata, Lactarius volemus, Cantharellus cibarius and Tricholoma terreum were analyzed for their fatty acid compositions and antioxidant capacities. The fungal species have been found with unsaturated fatty acid/saturated fatty acid ratio of 6.73 for Morchella elata, 4.12 for Lactarius volemus, 5.21 for Cantharellus cibarius, 3.73 for Tricholama terrum. In addition, the concentration of malondialdehyde which was an indicator of lipid peroxidation was also determined in these species. According to the results, free radical scavenging activity of Morchella elata and Lactarius volemus were found higher than the other species. Any of the mushroom species investigated were found having very high metal chelating activity. The results showed that the extract of Morchella elata and Lactarius volemus exhibited significant antioxidant activities. Hence, the mushrooms have a potential to be a natural antioxidant in food industries as antioxidant agent.

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Highly Oxygenated Meroterpenoids from Fruiting Bodies of the Mushroom Tricholoma terreum

Cited by 37 publications

References 28 publications

Suppression of Tumor Growth by Pleurotus ferulae Ethanol Extract through Induction of Cell Apoptosis, and Inhibition of Cell Proliferation and Migration

Suppression of Tumor Growth by Pleurotus ferulae Ethanol Extract through Induction of Cell Apoptosis, and Inhibition of Cell Proliferation and Migration

Bioactivities and Health Benefits of Mushrooms Mainly from China

Fatty acid composition and antioxidant capacity of some medicinal mushrooms in Turkey

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