Highly Pathogenic and Low Pathogenic Avian Influenza H5 Subtype Viruses in Wild Birds in Ukraine

Muzyka, Denys; Rula, Oleksandr; Tkachenko, S. V.; Muzyka, Nataliia; Köthe, Susanne; Pishchanskyi, O.; Stegniy, B. T.; Pantin‐Jackwood, Mary J.; Beer, Martin

doi:10.1637/11879-042718-resnote.1

Cited by 11 publications

(13 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Green, viruses detected in wild birds; orange, viruses detected in poultry; green-orange striped pattern, subclade detected in both wild birds and poultry at country level; light green, clade 2.2 viruses detected in wild birds and subclade unknown; light orange, clade 2.2 viruses detected in poultry and subclade unknown. References used [ 24 , 34 , 35 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ].…”

Section: Figurementioning

confidence: 99%

Highly Pathogenic Avian Influenza Viruses at the Wild–Domestic Bird Interface in Europe: Future Directions for Research and Surveillance

Verhagen¹,

Fouchier²,

Lewis

2021

Viruses

183

143

View full text Add to dashboard Cite

Highly pathogenic avian influenza (HPAI) outbreaks in wild birds and poultry are no longer a rare phenomenon in Europe. In the past 15 years, HPAI outbreaks—in particular those caused by H5 viruses derived from the A/Goose/Guangdong/1/1996 lineage that emerged in southeast Asia in 1996—have been occuring with increasing frequency in Europe. Between 2005 and 2020, at least ten HPAI H5 incursions were identified in Europe resulting in mass mortalities among poultry and wild birds. Until 2009, the HPAI H5 virus outbreaks in Europe were caused by HPAI H5N1 clade 2.2 viruses, while from 2014 onwards HPAI H5 clade 2.3.4.4 viruses dominated outbreaks, with abundant genetic reassortments yielding subtypes H5N1, H5N2, H5N3, H5N4, H5N5, H5N6 and H5N8. The majority of HPAI H5 virus detections in wild and domestic birds within Europe coincide with southwest/westward fall migration and large local waterbird aggregations during wintering. In this review we provide an overview of HPAI H5 virus epidemiology, ecology and evolution at the interface between poultry and wild birds based on 15 years of avian influenza virus surveillance in Europe, and assess future directions for HPAI virus research and surveillance, including the integration of whole genome sequencing, host identification and avian ecology into risk-based surveillance and analyses.

show abstract

Section: Figurementioning

confidence: 99%

Highly Pathogenic Avian Influenza Viruses at the Wild–Domestic Bird Interface in Europe: Future Directions for Research and Surveillance

Verhagen¹,

Fouchier²,

Lewis

2021

Viruses

183

143

View full text Add to dashboard Cite

show abstract

“…These two AIVs have different main replication sites, but H5N8 has a stronger ability to inhibit innate immunity than H4N6. Recently, there have been reports that many wild whooper swans and black-necked gray swans died after being infected with the H5N8 avian influenza virus ( Muzyka et al, 2019 ; Li et al, 2021 , 2022 ). We want to analyze further the causes of their deaths and the changes in RIG-I after infection with the H5N8 avian influenza virus.…”

Section: Discussionmentioning

confidence: 99%

“…The role of wild birds in spreading LPAIV is recognized, and the situation of wild birds spreading HPAIV is more complicated. Studies have found that some wild birds (such as whooper swans, cormorants, bar-headed geese, and grebes; Spackman et al, 2009 ; Okamatsu et al, 2010 ; Albini et al, 2014 ; Muzyka et al, 2019 ) will die on a large scale and quickly after being infected with HPAIV, so they have little effect on the long-distance transmission of the virus. Wild ducks (such as mallards) are less likely to die after being infected with HPAIV and seem to have obvious resistance to HPAIV, which many studies have also confirmed ( Sturm-Ramirez et al, 2005 ; Lee et al, 2016 ; Pantin-Jackwood et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

The Variation of Duck RIG-I-Mediated Innate Immune Response Induced by Different Virulence Avian Influenza Viruses

Zhai

Liu

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

In recent years, the emerging highly pathogenic avian influenza (HPAI) A(H5N8) virus has been reported with features of widely spread, an expanding host range, and cross-species transmission, attracting wide attention. The domestic duck plays a major role in the epidemiological cycle of the HPAI H5N8 virus, but little is known concerning innate immune responses during influenza infection in duck species. In this study, we used two wild-bird-origin viruses, H5N8 and H4N6, to conduct duck infection experiments, and detect the load of the two viruses, and retinoic acid-inducible gene I (RIG-I) and interferon β (IFN-β) in the host’s natural immune response. Through comparison, it is found that the expression levels of RIG-I and IFN-β are both fluctuating. The innate immunity starts rapidly within 6 h after infection and is inhibited by the virus to varying degrees. The expression of RIG-I and IFN-β decreased on 1–2 days post-infection (dpi). The HPAI H5N8 virus has a stronger inhibitory effect on RIG-I than the low pathogenic avian influenza (LPAI) H4N6 virus and is the strongest in the lungs. After infection with HPAI H5N8 virus, 2 dpi, viral RNA replicates in large amounts in the lungs. It has been proven that RIG-I and IFN-β play an important role in the innate immune response of ducks to HPAI H5N8 virus infection, especially in the lungs. The main battlefield of RIG-I and IFN-β after infection with the LPAI H4N6 virus is in the rectum. Both viruses have been effectively controlled after 7 dpi. These results will help to understand the transmission mechanisms of avian influenza virus in wild ducks and help effectively prevent and control avian influenza.

show abstract

“…As of December 2009, the respective clade 2.2 HPAI H5N1 virus had caused poultry or wild bird outbreaks in 62 countries reaching over three continents, including 24 European states (Cattoli, Fusaro, et al., 2009). After the first European cases were identified in Romania (Oprisan et al., 2006), Croatia (Savic et al., 2010) and the Ukraine (Muzyka et al., 2019) in summer–winter of 2005, Germany alongside 18 other European countries between Southern Sweden and Italy recorded their first cases almost simultaneously in January/February 2006 (Alexander, 2007; Cattoli, Fusaro, et al., 2009; WHO, 2012).…”

Section: –2007: Clade 22—h5n1mentioning

confidence: 99%

The genetics of highly pathogenic avian influenza viruses of subtype H5 in Germany, 2006–2020

King

Harder

Conraths

et al. 2020

Transbound Emerg Dis

Self Cite

View full text Add to dashboard Cite

show abstract

Highly Pathogenic and Low Pathogenic Avian Influenza H5 Subtype Viruses in Wild Birds in Ukraine

Cited by 11 publications

References 54 publications

Highly Pathogenic Avian Influenza Viruses at the Wild–Domestic Bird Interface in Europe: Future Directions for Research and Surveillance

Highly Pathogenic Avian Influenza Viruses at the Wild–Domestic Bird Interface in Europe: Future Directions for Research and Surveillance

The Variation of Duck RIG-I-Mediated Innate Immune Response Induced by Different Virulence Avian Influenza Viruses

The genetics of highly pathogenic avian influenza viruses of subtype H5 in Germany, 2006–2020

Contact Info

Product

Resources

About