Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models

Setsu, Genzui; Goto, Megumi; Ito, Kentaro; Taira, Tomoe; Miyamoto, Masaya; Watanabe, Tomohiro; Taniguchi, Toru; Umezaki, Yuma; Nakazawa, Yusuke; Uesugi, Shuhei; Mori, Kazuki; Horiuchi, Takao; Obuchi, Wataru; Minami, Masako; Shimada, Takashi; Wada, Chisa; Yoshida, Takanori; Higuchi, Saito

doi:10.1016/j.ejphar.2023.176184

European Journal of Pharmacology

2023

DOI: 10.1016/j.ejphar.2023.176184

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Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models

Genzui Setsu,

Megumi Goto,

Kentaro Ito

et al.

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Cited by 9 publications

References 39 publications

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Pharmacological inhibition of HPK1 synergizes with PD-L1 blockade to provoke antitumor immunity against tumors with low antigenicity

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Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models

Cited by 9 publications

References 39 publications

Pharmacological inhibition of HPK1 synergizes with PD-L1 blockade to provoke antitumor immunity against tumors with low antigenicity

Pharmacological inhibition of HPK1 synergizes with PD-L1 blockade to provoke antitumor immunity against tumors with low antigenicity

Opportunities and challenges for targeting HPK1 in cancer immunotherapy

Discovery of 1(2H)-phthalazinone and 1(2H)-isoquinolinone derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors

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