Highly prevalence of vitamin D deficiency among Brazilian women of reproductive age

Lopes, Vinicius Medina; Lopes, Joaquim Roberto Costa; Brasileiro, Jean Pierre Barguil; Oliveira, Ingrid; Lacerda, Ricardo Peclat; Andrade, Marcos Renato Dib; Tierno, Natália Ivet Zavattiero; Souza, Roberto Costa Cavalcante de; Motta, Luíz Augusto Casulari Roxo da

doi:10.1590/2359-3997000000216

Cited by 39 publications

(59 citation statements)

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“…Some studies report a high prevalence of VDD worldwide [50–52], even in countries at low latitudes, where there is usually higher UVB irradiation, resulting in conditions suitable for synthesis of the vitamin. A recent study involving Brazilian women of reproductive age presented a mean of 25(OH)D as 23.8 ± 8.7 ng/mL [53], values very close to ours. A recent study carried out in the United Kingdom evaluating individuals with class III obesity in preoperative bariatric surgery [54] showed a 90% percentage of serum vitamin D deficiency, assessed in the form of 25(OH)D in the sample studied, data similar to our findings.…”

Section: Discussionsupporting

confidence: 88%

Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity

Cordeiro

Pereira

Saboya³

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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Aim To evaluate the relationship of nonalcoholic fatty liver disease (NAFLD) with nutritional status of vitamin D in extreme obesity. Methods Descriptive cross-sectional study in individuals with class III obesity (BMI ≥ 40 kg/m2), aged ≥ 20 years to < 60 years. Data were obtained for weight, height, waist circumference (WC), and serum 25-hydroxyvitamin D (25(OH)D) levels. Vitamin D analysis was performed by high performance liquid chromatography (HPLC) and the cutoff points used for its classification were < 20 ng/mL for deficiency and 20–29.9 ng/ml for insufficiency. NAFLD gradation was conducted through histological evaluation by liver biopsy. Results The sample is comprised of 50 individuals (86% female). BMI and average weight were 44.1 ± 3.8 kg/m2 and 121.4 ± 21.4 kg, respectively. Sample distribution according to serum 25(OH)D levels showed 42% of deficiency and 48% of insufficiency. The diagnosis of NAFLD was confirmed in 100% of the individuals, of which 70% had steatosis and 30% had steatohepatitis. The highest percentage of 25(OH)D insufficiency was seen in individuals with steatosis (66%/n = 21) and steatohepatitis (93%/n = 16). All individuals with steatohepatitis presented VDD (p < 0.01). Conclusion The results of this study showed high prevalence of serum 25(OH)D inadequacy in individuals with class III obesity, which worsens as the stage of liver disease progresses.

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Section: Discussionsupporting

confidence: 88%

Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity

Cordeiro

Pereira

Saboya³

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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“…Interestingly, however, Lopes and cols. (8) pointed out the high prevalence of hypovitaminosis D in a young premenopausal population, which is in agreement with the low vitamin D levels described for postmenopausal and older women in Brazil. Vitamin D and its level of impact on fertility is a matter to be defined.…”

supporting

confidence: 83%

“…Although low levels of vitamin D are present in different diseases, infertile women studied in the article by Lopes and cols. (8) and also by others (9) did not show lower levels compared to controls. The literature in the field is ambiguous, showing both the importance of its adequate level and the lack of effect in infertility issues, such as polycystic ovary syndrome, endometriosis, myoma-induced infertility, male infertility, premature ovary failure and in vitro fertilization techniques (10,11).…”

mentioning

confidence: 53%

Vitamin D: the tricky hormone

Borba

2017

Arch. Endocrinol. Metab.

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Vitamin D, a pre-hormone produced in the skin under sunlight exposure, undergoes various metabolic steps until its active form, 1,25-dihydroxyvitamin D3, is formed. The intermediary form, 25-hydroxyvitamin D (25OHD), is the recommended form for monitoring vitamin D status. The presence of 1α-hydroxylase (CYP27B1) and the vitamin D receptor (VDR) in many cells indicates a possible local ability to synthesize 1,25-dihydroxyvitamin D3, the active metabolite of vitamin D, which has turned the attention of the medical community to the noncalcemic effects of vitamin D (1). In recent decades, several studies have demonstrated the association of circulating 25OHD levels with different diseases, their activity, and health conditions. A positive association was found in several disorders such as systemic lupus erythematosus (SLE) and its activity (2); chronic obstructive pulmonary disease (COPD) (3); inflammatory bowel disease (IBD) (4); systemic sclerosis; endocrine disorders; cancer; immune; cardiovascular and other chronic diseases (1,5); despite the presence of numerous positive observational studies, causation studies are lacking. A few good-quality randomized controlled studies on vitamin D supplementation in diverse disease endpoints show a modest effect on blood pressure, glycemic control, cancer, and immune response (5,6).Hypovitaminosis D is highly frequent worldwide and in Brazil, the prevalence ranges from 16% to 80% depending on the latitude and the population studied (1,7). Although low levels of vitamin D are present in different diseases, infertile women studied in the article by Lopes and cols. (8) and also by others (9) did not show lower levels compared to controls. The literature in the field is ambiguous, showing both the importance of its adequate level and the lack of effect in infertility issues, such as polycystic ovary syndrome, endometriosis, myoma-induced infertility, male infertility, premature ovary failure and in vitro fertilization techniques (10,11). Interestingly, however, Lopes and cols. (8) pointed out the high prevalence of hypovitaminosis D in a young premenopausal population, which is in agreement with the low vitamin D levels described for postmenopausal and older women in Brazil. Vitamin D and its level of impact on fertility is a matter to be defined. This controversy points out the wide effect of vitamin D and the need for a better understanding of its metabolism.Nolasco and cols. (12) showed a positive effect of vitamin D on pulmonary function in healthy postmenopausal women participating in an aquatic exercise program. Low vitamin D levels were previously described in pulmonary diseases as well as their

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“…Em território brasileiro, estudos mostram prevalência de níveis insuficientes e deficientes de 25(OH)D em cerca de 60% dos adolescentes (Peters et al, 2012); de 40% e 58% entre adultos jovens (Premaor et al, 2008;Maeda, 2010), e entre 42% e 83% em idosos, com taxas mais altas nos indivíduos com idades mais avançadas (Holick, 2007;Silva et al, 2008). Lopes et al (2017) encontraram uma prevalência de 81,1% de níveis Dissertação para defesa de Mestrado -Divisão de Urologia FMUSP 2 insuficientes e deficientes de vitamina D em mulheres com queixa de infertilidade atendidas em um centro de reprodução assistida em Brasília (Lopes et al, 2017), eles concluíram que a prevalência de deficiência de VD em mulheres em idade reprodutiva é elevada, independentemente do seu potencial fértil. Porém eles reforçam que o mecanismo de influência desse composto no sistema reprodutor feminino deve ser estudado de forma mais aprofundada (Lopes et al, 2017).…”

Section: Introductionunclassified

“…Lopes et al (2017) encontraram uma prevalência de 81,1% de níveis Dissertação para defesa de Mestrado -Divisão de Urologia FMUSP 2 insuficientes e deficientes de vitamina D em mulheres com queixa de infertilidade atendidas em um centro de reprodução assistida em Brasília (Lopes et al, 2017), eles concluíram que a prevalência de deficiência de VD em mulheres em idade reprodutiva é elevada, independentemente do seu potencial fértil. Porém eles reforçam que o mecanismo de influência desse composto no sistema reprodutor feminino deve ser estudado de forma mais aprofundada (Lopes et al, 2017).…”

Section: Introductionunclassified

Novas perspectivas no papel da vitamina D e sua influência com a qualidade do sêmen e hormônios sexuais em homens

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AGRADECIMENTOAgradeço principalmente aos meus pais pelo esforço imenso de me formar em uma profissional excelente.Aos meus Professores da graduação que me deram uma ótima formação e senso crítico.Aos amigos e familiares que estiveram presente nos momentos de alegria e deram o apoio tão necessário nos momentos de dificuldade. A toda equipe da clínica e laboratório Androscience que sempre me ajudaram e permitiram que esse estudo pudesse ser realizado, especialmente aos colegas Juliana Pariz, João Brunhara e Thiago Teixeira por toda ajuda no trabalho. Ao meu orientador Prof. Dr Jorge Hallak e a co-orientadora Prof.ª Dra Elaine Frade Costa por toda ajuda, orientação e ensinamentos, além de facilitarem para que isso seja possível. Agradeço especialmente a Dra Karina Barros, pelo exemplo, inspiração e todos ensinamentos que me proporcionou na carreira da Nutrição e como uma futura pesquisadora. A todos os demais colaboradores que auxiliaram nesse trabalho, inclusive a Elisa e o coordenador Alberto da pós-graduação da Urologia. Agradeço a Capes, Androscience e a pós-graduação da Urologia pelo auxílio financeiro. V

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Highly prevalence of vitamin D deficiency among Brazilian women of reproductive age

Cited by 39 publications

References 28 publications

Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity

Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity

Vitamin D: the tricky hormone

Novas perspectivas no papel da vitamina D e sua influência com a qualidade do sêmen e hormônios sexuais em homens

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