Highly rapid and non-enzymatic detection of cholesterol based on carbon nitride quantum dots as fluorescent nanoprobes

Chen, Ying; Yang, Gege; Gao, Shanshan; Zhang, Liangliang; Yu, Mengdi; Song, Chunxia; Lu, Ying

doi:10.1039/d0ra07495k

Cited by 11 publications

(5 citation statements)

References 36 publications

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“…These publications have addressed a range of topics, including the detection of cholesterol, AA, glutathione, glucose, dopamine, paracetamol, etc. By employing CNQDs as fluorescent nanoprobes, Chen et al established a rapid non-enzymatic cholesterol detection method with a broad detection range of 0–500 μmol/L and a low detection limit of 10.93 μmol/L. The fluorescence of CNQDs is reduced by >90% within 30 s by the formation of hydrogen bonds between cholesterol and the CNQDs, which contain -NH 2 , -NH, and -OH groups on the surface.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Graphitic Carbon Nitride Enters the Scene: A Promising Versatile Tool for Biomedical Applications

Xu,

Zhang,

et al. 2024

Langmuir

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Graphitic carbon nitride (g-C 3 N 4 ), since the pioneering work on visiblelight photocatalytic water splitting in 2009, has emerged as a highly promising advanced material for environmental and energetic applications, including photocatalytic degradation of pollutants, photocatalytic hydrogen generation, and carbon dioxide reduction. Due to its distinctive two-dimensional structure, excellent chemical stability, and distinctive optical and electrical properties, g-C 3 N 4 has garnered a considerable amount of interest in the field of biomedicine in recent years. This review focuses on the fundamental properties of g-C 3 N 4 , highlighting the synthesis and modification strategies associated with the interfacial structures of g-C 3 N 4 -based materials, including heterojunction, band gap engineering, doping, and nanocomposite hybridization. Furthermore, the biomedical applications of these materials in various domains, including biosensors, antimicrobial applications, and photocatalytic degradation of medical pollutants, are also described with the objective of spotlighting the unique advantages of g-C 3 N 4 . A summary of the challenges faced and future prospects for the advancement of g-C 3 N 4 -based materials is presented, and it is hoped that this review will inspire readers to seek further new applications for this material in biomedical and other fields.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Graphitic Carbon Nitride Enters the Scene: A Promising Versatile Tool for Biomedical Applications

Xu,

Zhang,

et al. 2024

Langmuir

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“…Compared to CQDs, g‐CNQDs display a more stable and prosperous PL behavior with a super high quantum yield (up to 36%), good water dispersibility, and low toxicity. [ 502 ] In addition, g‐CNQDs also demonstrated apparent PL emission in a longer wavelength range, making them an effective red light imaging candidate. [ 503 ] Barman and Sadhukhan first explored g‐CNQDs‐based sensing applications synthesized by a microwave‐mediated method in 2012 with average diameters and heights of 7 and 1.1 nm, respectively.…”

Section: Applicationsmentioning

confidence: 99%

Emerging Trends of Carbon‐Based Quantum Dots: Nanoarchitectonics and Applications

Guan

Geng

et al. 2023

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“…First, the bulk g-C 3 N 4 was prepared according to our previous method [41]. After 2 h ultrasonic treatment in 100 mL 5 M nitric acid, 1 g bulk g-C 3 N 4 was refluxed for 24 h under 120 • C. The product was then washed to neutrality with ultrapure water through 5 min centrifugation at 2680× g repeatedly.…”

Section: Synthesis Of Ptnp@g-c 3 N 4 Nanosheetsmentioning

confidence: 99%

Platinum Nanoparticles Loaded Graphitic Carbon Nitride Nanosheets with Enhanced Peroxidase-like Activity for H2O2 and Oxidase-Based Sensing

et al. 2023

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Platinum nanoparticles (PtNPs) are classical peroxidase-like nanozyme; self-agglomeration of nanoparticles leads to the undesirable reduction in stability and catalytic activity. Herein, a hybrid peroxidase-like nanocatalyst consisting of PtNPs in situ growing on g–C3N4 nanosheets with enhanced peroxidase-mimic catalytic activity (PtNP@g–C3N4 nanosheets) was prepared for H2O2 and oxidase-based colorimetric assay. g–C3N4 nanosheets can be used as carriers to solve the problem of poor stability of PtNPs. We observed that the catalytic ability could be maintained for more than 90 days. PtNP@g–C3N4 nanosheets could quickly catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB), and the absorbance of blue color oxidized TMB (oxTMB) showed a robust linear relationship with the concentration of H2O2 (the detection limit (LOD): 3.33 μM). By utilizing H2O2 as a mediator, this strategy can be applied to oxidase-based biomolecules (glucose, organophosphorus, and so on, that generate or consume hydrogen peroxide) sensing. As a proof of concept, a sensitive assay of cholesterol that combined PtNP@g–C3N4 nanosheets with cholesterol oxidase (ChOx) cascade catalytic reaction was constructed with an LOD of 9.35 μM in a widespread range from 10 to 800 μM (R2 = 0.9981). In addition, we also verified its ability to detect cholesterol in fetal bovine serum. These results showed application prospect of PtNP@g–C3N4 nanosheets-based colorimetry in sensing and clinical medical detection.

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Highly rapid and non-enzymatic detection of cholesterol based on carbon nitride quantum dots as fluorescent nanoprobes

Abstract: Highly rapid and non-enzymatic method for the detection of cholesterol was constructed based on carbon nitride quantum dots (CNQDs) as fluorescent nanoprobes. The fluorescence of CNQDs could be effectively and rapidly quenched by cholesterol.

Cited by 11 publications

References 36 publications

Graphitic Carbon Nitride Enters the Scene: A Promising Versatile Tool for Biomedical Applications

Graphitic Carbon Nitride Enters the Scene: A Promising Versatile Tool for Biomedical Applications

Emerging Trends of Carbon‐Based Quantum Dots: Nanoarchitectonics and Applications

Platinum Nanoparticles Loaded Graphitic Carbon Nitride Nanosheets with Enhanced Peroxidase-like Activity for H2O2 and Oxidase-Based Sensing

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