Highly recruited brown adipose tissue does not in itself protect against obesity

Essen, Gabriella von; Maldonado, Elaina; Lindsund, Erik; Cannon, Barbara; Nedergaard, Jan

doi:10.1016/j.molmet.2023.101782

Cited by 9 publications

(6 citation statements)

References 61 publications

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Section: Discussionmentioning

confidence: 99%

“…Diet-induced thermogenesis (DIT) has been found to increase UCP-1 under an obesogenic diet (containing high amounts of fat) (von Essen et al, 2017). However, von Essen et al ( 2017) report that the total amount of UCP-1 protein at thermoneutrality is dependent on the total BAT content itself (von Essen et al, 2017). When DIT occurs, the more UCP-1 present in BAT may limit obesity development during the HFD exposure, but it will not prevent obesity (von Essen et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…However, von Essen et al ( 2017) report that the total amount of UCP-1 protein at thermoneutrality is dependent on the total BAT content itself (von Essen et al, 2017). When DIT occurs, the more UCP-1 present in BAT may limit obesity development during the HFD exposure, but it will not prevent obesity (von Essen et al, 2017). Alcala et al (2017) conducted studies on HFD obese mice specifically to investigate BAT and WAT dysfunction (Alcala et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Chronic glucocorticoid exposure causes brown adipose tissue whitening, alters whole‐body glucose metabolism and increases tissue uncoupling protein‐1

Bel

Tai

Khaper

et al. 2022

Physiological Reports

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Adipose tissue (AT) has been found to exist in two predominant forms, white and brown. White adipose tissue (WAT) is the body's conventional storage organ, and brown adipose tissue (BAT) is responsible for non-shivering thermogenesis which allows mammals to produce heat and regulate body temperature. Studies examining BAT and its role in whole-body metabolism have found that active BAT utilizes glucose and circulating fatty acids and is associated with improved metabolic outcomes. While the beiging of WAT is a growing area of interest, the possibility of the BAT depot to "whiten" and store more triglycerides also has metabolic and health implications. Currently, there are limited studies that examine the effects of chronic stress and its ability to induce a white-like phenotype in the BAT depot. This research examined how chronic exposure to the murine stress hormone, corticosterone, for 4 weeks can affect the whitening process of BAT in C57BL/6 male mice. Separate treatments with mirabegron, a known β3adrenergic receptor agonist, were used to directly compare the effects of corticosterone with a beiging phenotype. Corticosterone-treated mice had significantly higher body weight (p ≤ 0.05) and BAT mass (p ≤ 0.05), increased adipocyte area (p ≤ 0.05), were insulin resistant (p ≤ 0.05), and significantly elevated expressions of uncoupling protein 1 (UCP-1) in BAT (p ≤ 0.05) while mitochondrial content remained unchanged. This whitened phenotype has not been previously associated with increased uncoupling proteins under chronic stress and may represent a compensatory mechanism being initiated under these conditions. These findings have implications for the study of BAT in response to chronic glucocorticoid exposure potentially leading to BAT dysfunction and negative impacts on wholebody glucose metabolism.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic glucocorticoid exposure causes brown adipose tissue whitening, alters whole‐body glucose metabolism and increases tissue uncoupling protein‐1

Bel

Tai

Khaper

et al. 2022

Physiological Reports

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show abstract

“…However, what will be measured is the amount of brown adipose tissue that can be activated by cold, and this is not necessarily what is relevant in the present context. Indeed, based on implications from mouse experiments [28], humans could have significant amounts of cold-induced brown adipose tissue thermogenic capacity but may be incapable of activating it for diet-induced thermogenesis. Data presented by Loeliger et al [12] would indicate this.…”

Section: Human Obesity and Brown Adipose Tissuementioning

confidence: 99%

“…Year stated is year of experiment. Some of these data have been included in publications: #1 and #2 [ 16 ]; #3 [ 28 ]; #4, #6 and #9 [ 13 ]; #5 unpublished—note that the wild-type mice in this cohort were not from our own breeding (for technical reasons); #7, #8 and #10 unpublished. …”

Section: Is the Effect Of Ucp1 Ablation On Mouse Obesity Consistent?mentioning

confidence: 99%

Brown adipose tissue: can it keep us slim? A discussion of the evidence for and against the existence of diet-induced thermogenesis in mice and men

Nedergaard,

von Essen,

Cannon

2023

Phil. Trans. R. Soc. B

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The issue under discussion here is whether a decrease in the degree of UCP1 activity (and brown adipose tissue activity in general) could be a cause of obesity in humans. This possibility principally requires the existence of the phenomenon of diet-induced thermogenesis. Obesity could be a consequence of a reduced functionality of diet-induced thermogenesis. Experiments in mice indicate that diet-induced thermogenesis exists and is dependent on the presence of UCP1 and thus of brown adipose tissue activity. Accordingly, many (but not all) experiments indicate that in the absence of UCP1, mice become obese. Whether similar mechanisms exist in humans is still unknown. A series of studies have indicated a correlation between obesity and low brown adipose tissue activity, but it may be so that the obesity itself may influence the estimates of brown adipose tissue activity (generally glucose uptake), partly explaining the relationship. Estimates of brown adipose tissue catabolizing activity would seem to indicate that it may possess a capacity sufficient to help maintain body weight, and obesity would thus be aggravated in its absence. This article is part of a discussion meeting issue ‘Causes of obesity: theories, conjectures and evidence (Part II)’.

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Futile cycles: Emerging utility from apparent futility

Sharma,

Khandelwal,

Wolfrum

2024

Cell Metabolism

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Highly recruited brown adipose tissue does not in itself protect against obesity

Cited by 9 publications

References 61 publications

Chronic glucocorticoid exposure causes brown adipose tissue whitening, alters whole‐body glucose metabolism and increases tissue uncoupling protein‐1

Chronic glucocorticoid exposure causes brown adipose tissue whitening, alters whole‐body glucose metabolism and increases tissue uncoupling protein‐1

Brown adipose tissue: can it keep us slim? A discussion of the evidence for and against the existence of diet-induced thermogenesis in mice and men

Futile cycles: Emerging utility from apparent futility

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