Highly Regio-Selective Synthesis of β-Amino Alcohol by Reaction with Aniline and Propylene Carbonate in Self Solvent System over Large Pore Zeolite Catalyst

Kinage, Anil K.; Upare, Pravin P.; Shivarkar, Anandkumar B.; Gupte, Sunil P.

doi:10.4236/gsc.2011.13013

Cited by 13 publications

(7 citation statements)

References 41 publications

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“…Intermediate 4 was converted into an acyl chloride, using the same conditions previously mentioned, and coupled with 3-chloro-4-methoxyaniline to generate the target compound 5 (Scheme 2A). Compound 7 (Scheme 2B) was synthesized from 3-chloro-4-methoxyaniline with ethyl carbonate catalyzed by molecular sieves (Kinage et al, 2011) to produce 6 , followed by coupling with 1 using Steglich conditions.…”

Section: Resultsmentioning

confidence: 99%

Structure-Based and Molecular Modeling Studies for the Discovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity

et al. 2019

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Chagas disease causes ~10,000 deaths each year, mainly in Latin America, where it is endemic. The currently available chemotherapeutic agents are ineffective in the chronic stage of the disease, and the lack of pharmaceutical innovation for Chagas disease highlights the urgent need for the development of new drugs. The enzyme cruzain, the main cysteine protease of Trypanosoma cruzi, has been explored as a validated molecular target for drug discovery. Herein, the design, molecular modeling studies, synthesis, and biological evaluation of cyclic imides as cruzain inhibitors are described. Starting with a micromolar-range cruzain inhibitor (3a, IC50 = 2.2 μM), this molecular optimization strategy resulted in the nanomolar-range inhibitor 10j (IC50 = 0.6 μM), which is highly active against T. cruzi intracellular amastigotes (IC50 = 1.0 μM). Moreover, most compounds were selective toward T. cruzi over human fibroblasts, which were used as host cells, and are less toxic to hepatic cells than the marketed drug benznidazole. This study enabled the discovery of novel chemical diversity and established robust structure-activity relationships to guide the design of optimized cruzain inhibitors as new trypanocidal agents.

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Section: Resultsmentioning

confidence: 99%

Structure-Based and Molecular Modeling Studies for the Discovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity

et al. 2019

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“…According to XPS results, PANI-containing ACF presented mainly amine groups while carbonized samples showed pyridine and positively charged nitrogen species (pyrrole and quaternary N). Therefore, amine groups present in PANI-containing ACF samples favor the propylene carbonate-ring opening because of their nucleophilic character (Kinage et al, 2011). The carbonate-ring opening is also enhanced by oxygen groups as reported by Cazorla-Amorós et al (2010).…”

Section: Enhancement Of Electrochemical Capacitors Performancementioning

confidence: 79%

Strategies to Enhance the Performance of Electrochemical Capacitors Based on Carbon Materials

et al. 2019

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The increasing worldwide energy consumption has contributed to both the vast growth of greenhouse emissions from carbon-containing fuels-based sources (coal, petroleum, etc.) and the depletion of the aforementioned sources. Given this scenario, the development of inexpensive and high-performing energy storage devices, which have the least possible environmental impact, is needed. At this point, electrochemical capacitors (ECs) or supercapacitors are a particular alternative or complementary option to batteries and fuel cells (FCs). ECs present high power output and long cycle life, but little power density compared to conventional or Lithium-ion batteries. Therefore, ECs are going to play a pivotal role, not only in portable electronic devices, but also to provide power density in hybrid electric vehicles. Many efforts have been focused on improving the energy output of ECs, although its enhancement keeping the high power density is still the cornerstone of most investigations. Many studies have been conducted toward the development of electrode materials such as metal oxides, conducting polymers or novel carbons. Nevertheless, they have shown important shortcomings to be implemented (i.e., high cost, low electrical conductivity, poor stability, etc.). Recent studies put the spotlight on nitrogen-containing carbon materials as candidates to improve the ECs performance in terms of energy. Optimizing the ECs configuration (asymmetric and hybrid) is another approach reported to tackle the challenge. Additionally, it is important to mention that the design of carbon materials obtained from inexpensive precursors lately attracted the attention of the research community. This review compiles works performed in our research group over the last years. The effect of nitrogen groups present in the carbon network on the capacitance will be reported and the study of asymmetric configuration to enhance de energy density will be discussed, either opening the potential window or by increasing the capacitance. Moreover, a lignin-based ECs will be described as an environmentally friendly approach. Finally, perspective and conceivable research guidelines in order to hurdle the challenges proposed to implement the carbon materials in the field of ECs will be addressed.

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“…As shown, the leakage current of the AC-P cell dramatically increased after 2.7 V and was notably higher than those of the N-doped AC cells, which is due to the prominent decomposition of the oxygen-containing functional groups. ,, It is noted that the measured leakage current decreases in the order of AC-NH 3 > AC-MEL > AC-NO. The negatively charged N-5 and N-6, due to their nucleophilic nature, can facilitate PC ring opening, leading to a side reaction current. In contrast, the positively charged N-Q reduces the possibility of nucleophilic attack, thus explaining the optimal stability of the AC-NO cell.…”

Section: Resultsmentioning

confidence: 99%

Manipulation of Nitrogen-Heteroatom Configuration for Enhanced Charge-Storage Performance and Reliability of Nanoporous Carbon Electrodes

Sutarsis

Patra

et al. 2020

ACS Appl. Mater. Interfaces

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In this study, various nitrogen-containing functional groups, namely, pyridine (N-6), pyrrole (N-5), oxidized N (N–O), and quaternary N (N-Q), are created on activated carbon (AC) surface via melamine, ammonia, and nitric oxide doping methods. N-5 and N-6 groups markedly alter the specific surface area and pore size of AC. N–O is found to affect electrolyte wettability, and the N-Q content is closely associated with AC electronic conductivity. The nitrogen-containing groups do not contribute to pseudocapacitance in propylene carbonate and acetonitrile electrolytes. However, the nitric-oxide-treated carbon (AC-NO) exhibits the best high-rate charge–discharge performance among the investigated materials. The N-Q-enriched and N-5/N-6-depleted AC-NO most effectively suppresses the leakage current and gas evolution of supercapacitors. Online gas chromatography is used to analyze the gaseous species produced from AC electrodes. With an appropriate surface functionality on carbon, the cell voltage can be increased to ∼3 V, increasing the energy and power densities. The aging behavior of the carbon electrodes with and without nitrogen modification after being floated at 2.5 V and 70 °C for 3 days is investigated. An effective strategy for enhancing supercapacitor performance and reliability is proposed.

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Highly Regio-Selective Synthesis of β-Amino Alcohol by Reaction with Aniline and Propylene Carbonate in Self Solvent System over Large Pore Zeolite Catalyst

Cited by 13 publications

References 41 publications

Structure-Based and Molecular Modeling Studies for the Discovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity

Structure-Based and Molecular Modeling Studies for the Discovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity

Strategies to Enhance the Performance of Electrochemical Capacitors Based on Carbon Materials

Manipulation of Nitrogen-Heteroatom Configuration for Enhanced Charge-Storage Performance and Reliability of Nanoporous Carbon Electrodes

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