Highly regionalized distribution of stromal cell‐derived factor‐1/CXCL12 in adult rat brain: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons

Banisadr, Ghazal; Skrzydelski, Delphine; Kitabgi, Patrick; Rostène, William; Parsadaniantz, Stéphane Melik

doi:10.1046/j.1460-9568.2003.02893.x

Cited by 150 publications

(161 citation statements)

References 35 publications

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“…It is clear from these studies and the results presented here that although CXCR4 is expressed by neural progenitors in all of these areas its expression is not restricted to these cells. Indeed, it is now clear that the SDF-1/CXCR4 system is widely expressed by neurons throughout the nervous system and possibly by glial elements as well (Banisadr et al, 2002a(Banisadr et al, , 2003Stumm et al, 2002;Tran and Miller, 2003;Dziembowska et al, 2005). The patterns of expression of the other chemokine receptors in the areas we examined are similar, consistent with previous findings that neural progenitor cells express numerous different chemokine receptor types (Peng et al, 2004;Tran et al, 2004;Pluchino et al, 2005).…”

supporting

confidence: 89%

“…20). Banisadr et al, 2003;Cowell and Silverstein, 2003;Tran and Miller, 2003) and their receptors (Banisadr et al, 2002a,b;Stumm et al, 2002;Chalasani et al, 2003;Cowell and Silverstein, 2003;Tran and Miller, 2003;Belmadani et al, 2005) exhibit a widespread and previously unappreciated expression pattern in the central and peripheral nervous systems. This suggests a number of roles for these molecules in the regulation of the nervous system beyond any role they may play in the organization of neuroinflammatory responses.…”

Section: Chemoattractant Effects Of Chemokines On Neural Progenitor Cmentioning

confidence: 99%

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Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain

Tran

Banisadr

Ren

et al. 2006

J of Comparative Neurology

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We previously demonstrated that chemokine receptors are expressed by neural progenitors grown as cultured neurospheres. To examine the significance of these findings for neural progenitor function in vivo, we investigated whether chemokine receptors were expressed by cells having the characteristics of neural progenitors in neurogenic regions of the postnatal brain. Using in situ hybridization we demonstrated the expression of CCR1, CCR2, CCR5, CXCR3, and CXCR4 chemokine receptors by cells in the dentate gyrus (DG), subventricular zone of the lateral ventricle, and olfactory bulb. The pattern of expression for all of these receptors was similar, including regions where neural progenitors normally reside. In addition, we attempted to colocalize chemokine receptors with markers for neural progenitors. In order to do this we used nestin-EGFP and TLXLacZ transgenic mice, as well as labeling for Ki67, a marker for dividing cells. In all three areas of the brain we demonstrated colocalization of chemokine receptors with these three markers in populations of cells. Expression of chemokine receptors by neural progenitors was further confirmed using CXCR4-EGFP BAC transgenic mice. Expression of CXCR4 in the DG included cells that expressed nestin and GFAP as well as cells that appeared to be immature granule neurons expressing PSA-NCAM, calretinin, and Prox-1. CXCR4-expressing cells in the DG were found in close proximity to immature granule neurons that expressed the chemokine SDF-1/CXCL12. Cells expressing CXCR4 frequently coexpressed CCR2 receptors. These data support the hypothesis that chemokine receptors are important in regulating the migration of progenitor cells in postnatal brain. Indexing terms stem cells; development; chemotaxis; brain repairDuring embryogenesis, neural stem/progenitor cells must migrate long distances from the germinal epithelia where they are born to their final destinations (Hatten, 1999;Alvarez-Buylla et al., 2001). During migration, stem cells may continue to divide and also become restricted in terms of their ultimate phenotypes. Thus, the timing of neuro-and gliogenesis in the developing embryo is precisely controlled (Rallu et al., 2002). The factors that determine the migration, proliferation, and differentiation of embryonic stem cells have been widely investigated and numerous factors have been shown to influence these processes (Lindvall et al., 2004). One group of molecules that has recently been shown to control progenitor cell migration in the nervous system are the chemokines (CHEMO-tactic cytoKINES) (Tran and © NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript Miller, 2003). The chemokines are a family of small secreted proteins that are known to be important regulators of leukocyte trafficking under both normal conditions and during inflammatory responses (Moser et al., 2004). Furthermore, it is now known that chemokine signaling has an important role to play in the developing embryo. Deletion of the genes for the CXCR4 chemokine receptor or f...

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supporting

confidence: 89%

Section: Chemoattractant Effects Of Chemokines On Neural Progenitor Cmentioning

confidence: 99%

Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain

Tran

Banisadr

Ren

et al. 2006

J of Comparative Neurology

Self Cite

219

228

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“…If we consider the DG as an example, CXCR4 is expressed by the most immature radial glia like stem cells as well as their progeny including rapidly amplifying cells, neuroblasts and immature granule neurons. Furthermore, SDF-1 is also expressed by neuronal cells in the DG (Banisadr et al, 2003;Stumm et al, 2002). The close juxtaposition of SDF-1 and CXCR4 in the adult DG suggests that CXCR4 may be an important regulator of adult neurogenesis in this part of the brain.…”

Section: Adult Stem Cell Developmentmentioning

confidence: 97%

CXCR4 signaling in the regulation of stem cell migration and development

Miller¹,

Banisadr²,

Bhattacharyya³

2008

Journal of Neuroimmunology

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The regulated migration of stem cells is a feature of the development of all tissues and also of a number of pathologies. In the former situation the migration of stem cells over large distances is required for the correct formation of the embryo. In addition, stem cells are deposited in niche like regions in adult tissues where they can be called upon for tissue regeneration and repair. The migration of cancer stem cells is a feature of the metastatic nature of this disease. In this article we discuss observations that have demonstrated the important role of chemokine signaling in the regulation of stem cell migration in both normal and pathological situations. It has been demonstrated that the chemokine receptor CXCR4 is expressed in numerous types of embryonic and adult stem cells and the chemokine SDF-1/CXCL12 has chemoattractant effects on these cells. Animals in which SDF-1/CXCR4 signaling has been interrupted exhibit numerous phenotypes that can be explained as resulting from inhibition of SDF-1 mediated chemoattraction of stem cells. Hence, CXCR4 signaling is a key element in understanding the functions of stem cells in normal development and in diverse pathological situations.

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“…administration of two members of CXC chemokines, IL-8/CXCL8 and IP-10/CXCL10, and two members of CC chemokines, MCP-1/CCL2 and RANTES/CCL5, are also effective in decreasing the short-term (2 h) food intake (Plata-Salaman & Borkoski 1994). More recently, we demonstrated by immunohistochemical studies that SDF-1a/CXCL12 is constitutively expressed in melanin-concentrating hormone (MCH)-expressing neurons located in the lateral hypothalamic area (LHA), neurons which are mainly involved in the stimulation of food intake (Banisadr et al 2003). Moreover, it was shown that the SDF-1/CXCL12 receptor, CXCR4, is also within MCH-expressing neurons confirming the hypothesis that SDF-1/ CXCL12 could alter the feeding behavior by acting on its receptor expressed by MCH neurons in the rat LHA.…”

Section: Chemokines and Feedingmentioning

confidence: 99%

Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation

Callewaere

Banisadr²,

Rostène³

et al. 2007

Journal of Molecular Endocrinology

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Chemokines are small secreted proteins that chemoattract and activate immune and non-immune cells both in vivo and in vitro. In addition to their well-established role in the immune system, several recent reports have suggested that chemokines and their receptors may also play a role in the central nervous system (CNS). The best known central action is their ability to act as immuno-inflammatory mediators. Indeed, these proteins regulate leukocyte infiltration in the brain during inflammatory and infectious diseases. However, we and others recently demonstrated that they are expressed not only in neuroinflammatory conditions, but also constitutively by different cell types including neurons in the normal brain, suggesting that they may act as modulators of neuronal functions. The goal of this review is to highlight the role of chemokines in the control of neuroendocrine functions. First, we will focus on the expression of chemokines and their receptors in the CNS, with the main spotlight on the neuronal expression in the hypothalamo-pituitary system. Secondly, we will discuss the role -we can now suspect -of chemokines and their receptors in the regulation of neuroendocrine functions. In conclusion, we propose that chemokines can be added to the well-described neuroendocrine regulatory mechanisms, providing an additional fine modulatory tuning system in physiological conditions.

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Highly regionalized distribution of stromal cell‐derived factor‐1/CXCL12 in adult rat brain: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons

Cited by 150 publications

References 35 publications

Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain

Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain

CXCR4 signaling in the regulation of stem cell migration and development

Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation

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